Terphenyllin is a flavonoid metabolite originally isolated from A. candidus that has antibacterial and cytotoxic properties.1,2 It is active against methicillin-resistant S. aureus 1 (MRSA-1), MRSA-2, and V. vulnificus (MICs = 31.27-31.47 ?g/ml) and cytotoxic to HeLa, A549, and HepG2 cells (IC50s = 18.87, 12.33, and 21.2 ?M, respectively).2 Terphenyllin inhibits HIV-1 integrase in coupled and strand transfer assays with IC50 values of 17.7 ?M and 47.7 ?M.3
1.Marchelli, R., and Vining, L.C.Terphenyllin, a novel p-terphenyl metabolite from aspergillus candidusJ. Antibiot. (Tokyo)28(4)328-331(1975) 2.Wang, W., Liao, Y., Tang, C., et al.Cytotoxic and antibacterial compounds from the coral-derived fungus Aspergillus tritici SP2-8-1Mar. Drugs15(11)E348(2017) 3.Singh, S.B., Jayasuriya, H., Dewey, R., et al.Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolitesJ. Ind. Microbiol. Biotechnol.30(12)721-731(2003)