α-MSH

目录号: GC14374纯度: >98.00%同义词: 美拉诺坦,α-Melanocyte-Stimulating Hormone, a-MSH

α -黑色素细胞刺激激素(α-MSH)是一种具有免疫调节特性的神经肽,由原黑素皮质素(POMC)翻译后加工产生。

Cas No.: 581-05-5

规格	价格	库存	数量
1 mg	¥350.00	现货	1
5 mg	¥1,050.00	现货	1
10 mg	¥1,820.00	现货	1
25 mg	¥3,920.00	现货	1

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产品描述 Description

Alpha-melanocyte-stimulating hormone (α-MSH) is a neuropeptide with immunomodulatory properties that is produced by post-translational processing of proproiomelanocortin (POMC). α-MSH binds to the MC1R receptor on melanocytes to stimulate melanin secretion, promote the formation of melanocyte dendrites, and protect melanocytes. α-MSH has an effective anti-inflammatory effect on immune cells. Moreover, α-MSH was shown to inhibit IFN-γ production in antigen-stimulated T cells[1-3].α-MSH- stimulates(1 µM; 72h) melanin production in B16 melanoma cells[4].α-MSH(0-10 ng/mL; 5-10min) enhances the role of protective responses under stress conditions such as UVR by increasing melanin production and reducing mitochondria-mediated apoptosis[5]. α-MSH(100 nM; 48 h) increased tyrosinase activity and melanin content by 56.5% and 61.7%, respectively, and α-MSH changed the level of metabolites in melanoma cells[6].

α-MSH (1mg / kg; i.v;12 h) can increase bacterial load in middle cerebral artery occlusion (MCAO) mice[7]. α-MSH(500 nM ; i.p;0-6 h) promotes fatty acid oxidation in WAT and BAT[8].

References:
[1]. Ichiyama T, Sato S, et,al. The neuroimmunomodulatory peptide alpha-MSH. Ann N Y Acad Sci. 2000;917:221-6. doi: 10.1111/j.1749-6632.2000.tb05386.x. PMID: 11268347.
[2]. Li C, Wu M, et,al. α- MSH Plays Anti-inflammatory and Anti-fungal Role in Aspergillus Fumigatus Keratitis. Curr Eye Res. 2022 Mar;47(3):343-351. doi: 10.1080/02713683.2021.2006235. Epub 2021 Dec 12. PMID: 34766863.
[3]. Schulte-HerbrÜggen O, Quarcoo D, et,al. Alpha-MSH promotes spontaneous post-ischemic pneumonia in mice via melanocortin-receptor-1. Exp Neurol. 2008 Apr;210(2):731-9. doi: 10.1016/j.expneurol.2008.01.006. Epub 2008 Jan 19. PMID: 18304533.
[4]. Song HS, Sim SS. Acteoside inhibits alpha-MSH-induced melanin production in B16 melanoma cells by inactivation of adenyl cyclase. J Pharm Pharmacol. 2009 Oct;61(10):1347-51. doi: 10.1211/jpp/61.10.0011. PMID: 19814867.
[5]: Choudhary R, Sharma A, et,al. Role of alpha-melanocyte stimulating hormone (α-MSH) in modulating the molecular mechanism adopted by melanocytes of Bos indicus under UVR stress. Mol Cell Biochem. 2020 Feb;465(1-2):141-153. doi: 10.1007/s11010-019-03674-w. Epub 2019 Dec 10. PMID: 31823188.
[6]. Seo SH, Jo JK, et,al. Metabolomics Reveals the Alteration of Metabolic Pathway by Alpha-Melanocyte-Stimulating Hormone in B16F10 Melanoma Cells. Molecules. 2020 Jul 26;25(15):3384. doi: 10.3390/molecules25153384. PMID: 32722640; PMCID: PMC7436294.
[7]. Schulte-HerbrÜggen O, Quarcoo D, et,al. Alpha-MSH promotes spontaneous post-ischemic pneumonia in mice via melanocortin-receptor-1. Exp Neurol. 2008 Apr;210(2):731-9. doi: 10.1016/j.expneurol.2008.01.006. Epub 2008 Jan 19. PMID: 18304533.
[8]. Gan L, Liu Z, et,al. α-MSH and Foxc2 promote fatty acid oxidation through C/EBPβ negative transcription in mice adipose tissue. Sci Rep. 2016 Nov 7;6:36661. doi: 10.1038/srep36661. PMID: 27819350; PMCID: PMC5098202.

α -黑色素细胞刺激激素(α-MSH)是一种具有免疫调节特性的神经肽,由原黑素皮质素(POMC)翻译后加工产生。α-MSH结合黑素细胞上的MC1R受体,刺激黑色素分泌,促进黑素细胞树突的形成,起到保护黑素细胞的作用。α-MSH对免疫细胞具有有效的抗炎作用。此外,α-MSH被证明可以抑制抗原刺激T细胞中IFN-γ的产生[1-3]。

α-MSH-刺激(1 µM; 72h)B16黑色素瘤细胞的黑色素生成[4]。α-MSH(0-10 ng/mL; 5-10min)通过增加黑色素生成和减少线粒体介导的细胞凋亡来增强应激条件下(如UVR)保护反应的作用[5]。α-MSH(100 nM; 48 h)使酪氨酸酶活性和黑色素含量分别提高了56.5%和61.7%,α-MSH改变了黑色素瘤细胞代谢产物的水平[6]。

α-MSH (1mg / kg; i.v;12 h)可增加MCAO小鼠细菌负荷[7]。α-MSH(500 nM ; i.p;0-6 h)促进WAT和BAT的脂肪酸氧化[8]。

实验参考方法 Experimental Reference Method

Cell experiment [1]:
Cell lines	B16 melanoma cells
Preparation Method	Cells treated with α-MSH in culture dishes (60 mm) were incubated for 72 h at 37℃ in a CO2 chamber.
Reaction Conditions	1 µM; 72h
Applications	α-MSH- stimulates melanin production in B16 melanoma cells.
Animal experiment [2]:
Animal models	Three-week old C57BL/6J male mice
Preparation Method	Mice were injected either PBS or α-MSH (500 nM) intraperitoneally once a day for two days before dark cycle. Inguinal adipose tissue (iWAT) was removed at 0.5 h, 1 h, 2 h, 4 h and 6 h after the last injection from the treatment group.
Dosage form	500 nM ; i.p;0-6 h
Applications	α-MSH promotes fatty acid oxidation in white (WAT) and brown adipose tissue (BAT).
References: [1]. Song HS, Sim SS. Acteoside inhibits alpha-MSH-induced melanin production in B16 melanoma cells by inactivation of adenyl cyclase. J Pharm Pharmacol. 2009 Oct;61(10):1347-51. doi: 10.1211/jpp/61.10.0011. PMID: 19814867. [2]. Gan L, Liu Z, et,al. α-MSH and Foxc2 promote fatty acid oxidation through C/EBPβ negative transcription in mice adipose tissue. Sci Rep. 2016 Nov 7;6:36661. doi: 10.1038/srep36661. PMID: 27819350; PMCID: PMC5098202.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号

581-05-5

同义词

美拉诺坦,α-Melanocyte-Stimulating Hormone, a-MSH

化学名

(4S,5Z,7S,8Z,10S,11Z,13S,14Z,16S,17Z,20Z,22S)-7-((1H-imidazol-5-yl)methyl)-16-((1H-indol-3-yl)methyl)-26-amino-10-benzyl-13-(3-guanidinopropyl)-5,8,11,14,17,20-hexahydroxy-22-((S)-2-((Z)-hydroxy(((S)-1-hydroxy-1-imino-3-methylbutan-2-yl)imino)methyl)pyrro

SMILES

CC([C@@](/N=C(O)/[C@]1([H])CCCN1C([C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C)([H])CO)([H])CC2=CC=C(O)C=C2)([H])CO)([H])CCSC)([H])CCC(O)=O)([H])CC3=CN=CN3)([H

分子式

C₇₇H₁₀₉N₂₁O₁₉S

分子量

1664.9 g/mol

溶解性

25mg/ml in Water

保存条件

Desiccate at -20°C

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