关于 "Bile Acids & Microbiome" 的结果34+ 个结果
- Sinapinic acid (Sinapic acid)CAS: 530-59-6
A phenylpropanoid hydroxycinnamic acid with diverse biological activities
- Rotundic acidCAS: 20137-37-5
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.
- Pomolic acidCAS: 13849-91-7
Pomolic acid is a pentacyclic triterpene isolated from Euscaphis japonica, and is highly effective in inhibiting cell growth and induces apoptosis.
Apoptosis - Maslinic AcidCAS: 4373-41-5
Maslinic Acid是一种五环三萜酸，广泛存在于橄榄和其他植物中。Maslinic Acid具有抗炎、抗氧化、抗肿瘤、降血糖和神经保护等多种生物活性。
- Myristoleic AcidCAS: 544-64-9
Myristoleic Acid一种生物活性不饱和脂肪酸，能够从肉豆蔻科植物种子中提取，或由肉豆蔻酸通过生物体内的去饱和酶生物合成。
Apoptosis - Neogambogic acidCAS: 93772-31-7
Neogambogic acid 是藤黄的有效成分，可诱导细胞凋亡并具有抗癌作用。 Neogambogic acid 对耐甲氧西林的金黄色葡萄球菌 (MRSA) 具有明显的抑制活性。
- Asiatic acidCAS: 464-92-6
Asiatic acid是一种五环三萜类化合物，可抑制EGFR活性，对野生型EGFR和T790M/L858R EGFR的IC 50 值分别为0.035nM和0.348nM。
- Chicoric acidCAS: 6537-80-0
Chicoric acid是一种羟基肉桂酸，属于苯丙醇类有机化合物，存在于菊苣、 蒲公英和罗勒等多种植物中，具有抗氧化、抗炎、抗糖尿病、抗病毒等多种生物活性。
- Minodronic acidCAS: 180064-38-4
Minodronic acid (YM529, ONO-5920) is a third-generation nitrogen-cotaining bisphosphonate that is used for the treatment of osteoporosis. Minodronic acid is an aminobisphosphonate that is a selective antagonist of purinergic P2X2/3 receptors involved in pain.
- Ursonic acidCAS: 6246-46-4
Ursonic acid (Prunol, Malol, beta-Ursolic acid, NSC4060, CCRIS 7123, TOS-BB-0966), present in many plants, is a pentacyclic triterpenoid that can be used as a cosmetics additive and serve as a starting material for synthesis of more potent bioactive derivatives, such as experimental antitumor agents. Ursonic acid induces the apoptosis of human cancer cells through multiple signaling pathways.
- (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))CAS: 866541-93-7
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))是一种新型的、具有口服活性的Bcl-2家族蛋白抑制剂，可抑制Bcl-2（K i =260±30nM），Mcl-1（K i =170±10nM）和Bcl-xL（K i =480±40nM）。
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC31511 | Sinapinic acid (Sinapic acid) | 530-59-6 | Other Apoptosis | ||
A phenylpropanoid hydroxycinnamic acid with diverse biological activities | |||||
| GC38609 | Rotundic acid | 20137-37-5 | Other Apoptosis | ||
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways. | |||||
| GC62483 | Pomolic acid | 13849-91-7 | Apoptosis | ||
Pomolic acid is a pentacyclic triterpene isolated from Euscaphis japonica, and is highly effective in inhibiting cell growth and induces apoptosis. | |||||
| GC43462 | Dihydrolipoic Acid | 462-20-4 | Cancer stem cell | ||
A reduced form of α-lipoic acid | |||||
| GC17632 | Maslinic Acid | 4373-41-5 | HIV | ||
Maslinic Acid是一种五环三萜酸，广泛存在于橄榄和其他植物中。Maslinic Acid具有抗炎、抗氧化、抗肿瘤、降血糖和神经保护等多种生物活性。 | |||||
| GC11087 | Myristoleic Acid | 544-64-9 | Apoptosis | ||
Myristoleic Acid一种生物活性不饱和脂肪酸，能够从肉豆蔻科植物种子中提取，或由肉豆蔻酸通过生物体内的去饱和酶生物合成。 | |||||
| GC15880 | Penicillic Acid | 90-65-3 | Other Apoptosis | ||
A mycotoxin that inhibits quorum sensing | |||||
| GC38392 | Euscaphic acid | 53155-25-2 | Other Apoptosis | ||
A triterpene with diverse biological activities | |||||
| GC41645 | Jacaric Acid | 28872-28-8 | Tumor Microenvironment | ||
A conjugated PUFA | |||||
| GC38969 | Neogambogic acid | 93772-31-7 | Bacterial | ||
Neogambogic acid 是藤黄的有效成分，可诱导细胞凋亡并具有抗癌作用。 Neogambogic acid 对耐甲氧西林的金黄色葡萄球菌 (MRSA) 具有明显的抑制活性。 | |||||
| GC30110 | Oleic acid (9-cis-Octadecenoic acid) | 112-80-1 | Endogenous Metabolite | ||
油酸（9-顺式-十八碳烯酸）是一种单不饱和的Omega-9脂肪酸，存在于植物和动物中。 | |||||
| GC14533 | Kynurenic acid | 492-27-3 | Other Apoptosis | ||
Kynurenic acid 是一种内源性色氨酸代谢物，是一种针对 NMDA、谷氨酸、α7 烟碱乙酰胆碱受体的广谱拮抗剂。 | |||||
| GC11459 | Xanthurenic acid | 59-00-7 | mGluR | ||
Xanthurenic acid是一种内源性II组代谢型谷氨酸受体激动剂，参与丘脑的感觉传递。 | |||||
| GN10702 | Asiatic acid | 464-92-6 | Parasite | ||
Asiatic acid是一种五环三萜类化合物，可抑制EGFR活性，对野生型EGFR和T790M/L858R EGFR的IC50值分别为0.035nM和0.348nM。 | |||||
| GC52076 | Temozolomide Acid | 113942-30-6 | Drug Metabolite | ||
An active metabolite of temozolomide | |||||
| GC64993 | Chicoric acid | 6537-80-0 | Reactive Oxygen Species | ||
Chicoric acid是一种羟基肉桂酸，属于苯丙醇类有机化合物，存在于菊苣、 蒲公英和罗勒等多种植物中，具有抗氧化、抗炎、抗糖尿病、抗病毒等多种生物活性。 | |||||
| GC36613 | Minodronic acid | 180064-38-4 | Other Apoptosis | ||
Minodronic acid (YM529, ONO-5920) is a third-generation nitrogen-cotaining bisphosphonate that is used for the treatment of osteoporosis. Minodronic acid is an aminobisphosphonate that is a selective antagonist of purinergic P2X2/3 receptors involved in pain. | |||||
| GC37873 | Ursonic acid | 6246-46-4 | Other Apoptosis | ||
Ursonic acid (Prunol, Malol, beta-Ursolic acid, NSC4060, CCRIS 7123, TOS-BB-0966), present in many plants, is a pentacyclic triterpenoid that can be used as a cosmetics additive and serve as a starting material for synthesis of more potent bioactive derivatives, such as experimental antitumor agents. Ursonic acid induces the apoptosis of human cancer cells through multiple signaling pathways. | |||||
| GC34096 | (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) | 866541-93-7 | Autophagy | ||
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))是一种新型的、具有口服活性的Bcl-2家族蛋白抑制剂，可抑制Bcl-2（Ki=260±30nM），Mcl-1（Ki=170±10nM）和Bcl-xL（Ki=480±40nM）。 | |||||
| GC10480 | Betulinic acid | 472-15-1 | NF-κB | ||
白桦脂酸（Betulinic acid）是一种天然的五环三萜类化合物，是真核细胞拓扑异构酶I的抑制剂，IC50值为5μM。 | |||||
| GC12139 | Gambogic Acid | 2752-65-0 | Autophagy | ||
Gambogic Acid 是一种细胞渗透性 caspase 激活剂和细胞凋亡诱导剂，常用于乳腺癌、肺癌和肝癌等的研究。 | |||||
| GC17057 | Lithocholic Acid | 434-13-9 | Endogenous Metabolite | ||
A toxic secondary bile acid | |||||
| GC34134 | Glycocholic acid | 475-31-0 | Bcl-2 Family | ||
Glycocholic acid是一种参与脂肪乳化的结晶胆汁酸，是胆酸与甘氨酸的结合物，它以钠盐的形式存在于哺乳动物的胆汁中。 | |||||
| GC47399 | Geranylgeranoic Acid | 83807-40-3 | Mitochondrial Metabolism | ||
An isoprenoid with anticancer activity | |||||