Chicoric acid is a hydroxycinnamic acid, belonging to the phenylpropanoid class of organic compounds. Chicoric acid is found in various plants, including chicory, dandelion, and basil, and possesses multiple biological activities such as antioxidant, anti-inflammatory, anti-diabetic, and antiviral effects[1, 2]. Chicoric acid can promote insulin release and glucose uptake[3]. Chicoric acid can alleviate cognitive impairment caused by oxidative stress[4].
In vitro, pretreatment of human umbilical vein endothelial cells (HUVECs) with Chicoric acid (25-200µM) for 30min inhibited apoptosis induced by high glucose/high fat (HG+HF) medium, and reduced HG+HF-induced IκBα phosphorylation and degradation, as well as subsequent p65 NFκB nuclear translocation[5]. Treatment of 3T3-L1 preadipocytes with Chicoric acid (10-200µM) for 24-72h inhibited cell viability in a dose- and time-dependent manner, induced apoptosis, and reduced mitochondrial membrane potential (MMP)[6].
In vivo, Chicoric acid (20mg/kg) administered via intraperitoneal injection to mice with compound 48/80-induced anaphylactic shock reduced serum histamine levels and mortality[7].
References:
[1] Duda Ł, Kłosiński K K, Budryn G, et al. Medicinal use of chicory (Cichorium intybus L.)[J]. Scientia Pharmaceutica, 2024, 92(2): 31.
[2] Ferrare K, Bidel L P R, Awwad A, et al. Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect[J]. Journal of ethnopharmacology, 2018, 215: 241-248.
[3] Tousch D, Lajoix A D, Hosy E, et al. Chicoric acid, a new compound able to enhance insulin release and glucose uptake[J]. Biochemical and biophysical research communications, 2008, 377(1): 131-135.
[4] Wang Y, Diao Z, Li J, et al. Chicoric acid supplementation ameliorates cognitive impairment induced by oxidative stress via promotion of antioxidant defense system[J]. RSC advances, 2017, 7(57): 36149-36162.
[5] Ma X, Zhang J, Wu Z, et al. Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses[J]. Journal of Receptors and Signal Transduction, 2021, 41(4): 378-392.
[6] Xiao H, Wang J, Yuan L, et al. Chicoric acid induces apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways[J]. Journal of agricultural and food chemistry, 2013, 61(7): 1509-1520.
[7] Lee N Y, Chung K S, Jin J S, et al. Effect of chicoric acid on mast cell-mediated allergic inflammation in vitro and in vivo[J]. Journal of natural products, 2015, 78(12): 2956-2962.
Chicoric acid是一种羟基肉桂酸，属于苯丙醇类有机化合物，存在于菊苣、 蒲公英和罗勒等多种植物中，具有抗氧化、抗炎、抗糖尿病、抗病毒等多种生物活性[1, 2]。Chicoric acid能够促进胰岛素释放和葡萄糖吸收[3]。Chicoric acid能够缓解由氧化应激引起的认知障碍[4]。
在体外，Chicoric acid（25-200µM）预处理人脐静脉内皮细胞（HUVECs）30min，抑制了高糖/高脂（HG+HF）培养基诱导的HUVECs凋亡，减少了HG+HF诱导的IκBα磷酸化和降解，以及随后的p65 NFκB核转位[5]。Chicoric acid（10-200µM）处理3T3-L1前脂肪细胞24-72h，以剂量和时间依赖性方式抑制了细胞活力，诱导了细胞凋亡，降低了线粒体膜电位（MMP）[6]。
在体内，Chicoric acid（20mg/kg）通过腹腔注射治疗化合物48/80诱发的过敏性休克小鼠，降低了小鼠血清组胺水平和死亡率[7]。