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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. 产品名称 Information
  2. GC44290 NAADP (sodium salt)

    Nicotinic acid adenine dinucleotide phosphate

    A secondary messenger that induces calcium mobilization
  3. GC44059 LG 100268

    6-[1-(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)环丙基]-3-吡啶羧酸,LG268

     LG 100268 是一种高效、选择性的视黄醇X受体(RXR)激动剂，EC50值为4nM，可强力激活RXR同源二聚体。
  4. GC43999 Ketanserin (tartrate)

    酒石酸酮色林,R41468 tartrate

     A potent 5-HT2 receptor antagonist
  5. GC43922 Isovaleryl-L-carnitine (chloride)

    L-异戊酰基肉碱

     Isovaleryl-L-carnitine (chloride)是L-肉碱的类似物，可延迟小鼠C2.8肝细胞中起始的凋亡细胞死亡。
  6. GC43599 Emetine (hydrochloride)

    盐酸吐根碱

    An alkaloid with diverse biological activities
  7. GC43359 Cytochalasin E

    细胞松弛素E

     Inhibitor of actin polymerization
  8. GC43354 Cysmethynil

    Icmt Inhibitor

     An inhibitor of protein prenylation
  9. GC43321 CPTH6 (hydrobromide) A Gcn5 and pCAF HAT inhibitor
  10. GC43265 Chromomycin A2

    色霉素A2

     An antibacterial and anticancer aureolic acid
  11. GC43105 C8 Ceramide (d18:1.8:0)

    N-辛酰基-D-神经鞘氨醇; N-Octanoyl-D-erythro-sphingosine

     A cell-permeable ceramide analog
  12. GC43048 C18 dihydro Ceramide (d18:0/18:0)

    二羟基神经酰胺,Cer(d18:0/18:0)

     C18 dihydro Ceramide (d18:0/18:0)是一种生物活性鞘脂，也是缺乏4,5-反式双键的C18 ceramide从头合成的前体。
  13. GC42677 ABO (hydrochloride) A modulator of annexin A7
  14. GC42414 4-hydroxy Tolbutamide

    4-羟基甲苯磺丁脲,Hydroxytolbutamide

     4-Hydroxy Tolbutamide是第一代磺酰脲类降血糖药甲苯磺丁脲在人体内经CYP2C9代谢的主要产物。
  15. GC41625 Oroxylin A

    千层纸素A; Baicalein 6-methyl ether; 6-Methoxybaicalein

     A flavonoid with diverse biological activities
  16. GC41308 GPP 78

    CAY10618

     Inhibitor of Nampt
  17. GC41242 Acridine Orange

    吖啶橙,NSC 194350

     Acridine Orange是一种可穿透细胞的核酸选择性荧光染料， Acridine Orange可与DNA或RNA结合时产生荧光，与双链DNA结合时产生绿色荧光（激发光为488nm；发射光为530nm绿色荧光）。
  18. GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone

    2,3-二甲氧基-5-甲基-1,4-苯醌,CoQ0

     An intermediate in the synthesis of ubiquinones that has anticancer activity
  19. GC40911 Glycine-β-muricholic Acid

    Gly-MCA, GβMCA

     Glycine-β-muricholic Acid是一种有效的、稳定的、对精氨酸有选择性的口服生物活性FXR抑制剂，是鼠特异性初级胆汁酸β-鼠胆酸的甘氨酸结合形式。
  20. GC40861 Pinosylvin

    赤松素

     A stilbene with diverse biological activities
  21. GC40793 L-erythro Sphinganine (d18:0)

    L-苏式-二氢鞘胺醇

     A bioactive sphingolipid
  22. GC40792 D-threo Sphinganine (d18:0)

    D-苏式二氢鞘氨醇

     A bioactive sphingolipid
  23. GC40775 Dexamethasone

    地塞米松; Hexadecadrol; Prednisolone F

     地塞米松是糖皮质激素家族的一员，可以保护软骨结构和功能免受关节炎相关变化的影响，包括基质丢失、炎症和软骨活力。
  24. GC40769 Asperphenamate

    Anabellamide, Auranamide, NSC 306231

     A fungal secondary metabolite
  25. GC40685 Pentoxifylline

    NSC 637086, Oxpentifylline

     Pentoxifylline is a methylxanthine derivative.
  26. GC40484 Ferulic Acid methyl ester

    阿魏酸甲酯; Methyl ferulate

     A lipophilic antioxidant
  27. GC34924 NSC 185058 NSC 185058是一种ATG4B的合成抑制剂，IC50值为51μM。
  28. GC34918 MW-150 dihydrochloride dihydrate

    MW01-18-150SRM dihydrochloride dihydrate

     An inhibitor of p38α MAPK
  29. GC34862 WYC-209

    4,5-二(羟甲基)-2-苯基-1H-咪唑

     WYC-209是一种合成类视黄醇，能抑制恶性小鼠黑色素瘤肿瘤再生细胞(TRC)的增殖，IC50值为0.19μM。WYC-209主要细胞靶点是维甲酸受体(RARs)。
  30. GC34849 UBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.
  31. GC34745 PTI-428

    PTI-428

     PTI-428是一种可增强并稳定囊性纤维化跨膜传导调节因子（CFTR）蛋白功能的特异性调节剂。
  32. GC34686 Nidufexor

    LMB763

    An FXR partial agonist
  33. GC34532 CFTR corrector 2 FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.
  34. GC40227 Indomethacin-d4

    吲哚美辛-D4; Indometacin-d4

     An internal standard for the quantification of indomethacin
  35. GC40226 Curcumin-d6

    (1E,4Z,6E)-5-羟基-1,7-二[4-羟基-3-(甲氧基-D3)苯基]-1,4,6-庚三烯-3-酮,Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6

     An internal standard for the quantification of curcumin
  36. GC40080 Bosutinib-d8

    SKI-606 D8

     An internal standard for the quantification of bosutinib
  37. GC40065 Meloxicam-d3

    美洛昔康 d3

     An internal standard for the quantification of meloxicam
  38. GC40044 Zymostenol

    Δ8-Cholesterol

     A precursor of cholesterol
  39. GC40007 Malformin A

    Malformin A1

     A cyclopentapeptide fungal metabolite with diverse biological activities
  40. GC34390 Autocamtide 2, amide Autocamtide2,amide是钙调蛋白激酶(CaMK)家族实验的底物(100μMfinalconcentration)。
  41. GC34330 XRK3F2 XRK3F2 is an inhibitor of the p62-ZZ domain that blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.
  42. GC34173 LG-100064

    4-[(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)羰基]苯甲酸

     LG-100064是一种类视黄醇X受体(retinoid-X-receptor(RXR))激动剂，对RXRα，RXRβ和RXRγ的EC50值分别为330nM，200nM和260nM；LG-100064可用于癌症研究。
  43. GC34117 SMER18 SMER18是Rapamycin的一种小分子增强剂,充当mTOR非依赖性的的自噬诱导剂。
  44. GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))

    (R)-(-)-醋酸棉酚; AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid

     (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))是一种新型的、具有口服活性的Bcl-2家族蛋白抑制剂，可抑制Bcl-2（Ki=260±30nM），Mcl-1（Ki=170±10nM）和Bcl-xL（Ki=480±40nM）。
  45. GC34094 Mycro 3 Mycro 3 is a potent and selective inhibitor of c-Myc in whole cell assays. Mycro 3 also shows weak inhibitory activity against AP-1.
  46. GC34072 Talmapimod (SCIO-469)

    他匹莫德; SCIO-469

    A p38 MAPK inhibitor
  47. GC34057 TBHQ (tert-Butylhydroquinone)

    特丁基对苯二酚; tert-Butylhydroquinone

     TBHQ(tert-Butylhydroquinone)是一种强效的酚类抗氧化剂，能够减轻氧化应激和炎症反应。
  48. GC34035 Meglutol (Dicrotalic acid)

    3-羟基-3-甲基谷氨酸,Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid

     An HMG-CoA reductase inhibitor
  49. GC34014 Trimetazidine dihydrochloride

    盐酸曲美他嗪

     Trimetazidine dihydrochloride是一种亲脂性piperazine衍生物，用于治疗心绞痛。
  50. GC34010 Danshensu (Dan shen suan A)

    丹参素; Dan shen suan A; Salvianic acid A

     丹参素是丹参的一种活性成分，通过激活 Nrf2 信号通路显示出广泛的心血管益处。
  51. GC34009 Nitroprusside disodium dihydrate (Sodium nitroprusside dihydrate)

    硝普钠二水合物; Sodium nitroprusside dihydrate; Sodium Nitroferricyanide(III) Dihydrate

     Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.

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