Autophagy(自噬)

Cat.No. 产品名称 Information

GN10318 Danshensu

丹参素

A salvianolic acid with diverse biological activities

GC34010 Danshensu (Dan shen suan A)

丹参素; Dan shen suan A; Salvianic acid A

丹参素是丹参的一种活性成分，通过激活 Nrf2 信号通路显示出广泛的心血管益处。

GC30072 Dansylcadaverine (Monodansyl cadaverine)

丹酰尸胺; Monodansyl cadaverine

A fluorescent marker for autophagic vacuoles

GC30056 Danthron (Dantron)

1,8-二羟基蒽醌; Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone

Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.

GC30054 Dantrolene sodium hemiheptahydrate (Dantrolene sodium hydrate)

丹曲林钠,Dantrolene sodium hydrate

Dantrolene sodium hemiheptahydrate (Dantrium) ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.

GC15217 Danusertib (PHA-739358)

达鲁舍替,5-Amido-pyrrolopyrazole 9d

A pan-Aurora kinase and Abl inhibitor

GN10336 Daphnetin

瑞香素; 7,8-Dihydroxycoumarin

A coumarin derivative with diverse biological activities

GC12942 DAPT (GSI-IX)

gamma-Secretase Inhibitor IX, DAPT, GSI-IX

DAPT (GSI-IX) 是一种具有口服活性的 γ-分泌酶抑制剂，对人原代神经元培养物中产生的总淀粉样蛋白-β (Aβ) 和 Aβ42 的 IC50 分别为 115 nM 和 200 nM。

GC15568 Dasatinib (BMS-354825)

达沙替尼; BMS-354825

Dasatinib (BMS-354825)是一种高效、口服生物利用度高的多靶点酪氨酸激酶抑制剂，对BCR-ABL、SRC家族激酶、c-KIT和PDGFR-β的IC₅₀分别为0.4nM、0.5nM、100nM和180nM。

GC35812 Dasatinib hydrochloride

达沙替尼盐酸盐; BMS-354825 hydrochloride

An inhibitor of Abl and Src

GC12828 Daunorubicin

柔红霉素; Daunomycin; RP 13057; Rubidomycin

Daunorubicin是一种天然来源的蒽环类抗生素，通过嵌入DNA双链并抑制拓扑异构酶Ⅱ活性，阻断DNA复制与转录，从而诱导肿瘤细胞凋亡。

GC10354 Daunorubicin HCl

盐酸柔红霉素; Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride

Daunorubicin HCl是一种天然来源的蒽环类抗生素，通过嵌入DNA双链并抑制拓扑异构酶Ⅱ活性，阻断DNA复制与转录，从而诱导肿瘤细胞凋亡。

GC33003 Daurisoline ((R,R)-Daurisoline)

蝙蝠葛苏林碱; (R,R)-Daurisoline

An alkaloid with diverse biological activities

GC10824 DBeQ

JRF 12

A selective inhibitor of the ATPase p97

GC65191 DC-LC3in-D5 DC-LC3in-D5 通过减弱 LC3B 脂化作用而作为自噬 (autophagy) 抑制剂。DC-LC3in-D5 与 LC3B 结合。DC-LC3in-D5 破坏 LC3B-LBP2 相互作用，IC50 为 200 nM。DC-LC3in-D5 可能通过抑制自噬有助于抗 HCV 或肿瘤的联合治疗。

GC19485 DC661 A PPT1 inhibitor

GC70757 DCAP DCAP是一种广谱抗生素，靶向革兰氏阳性和革兰氏阴性细菌的膜。

GC35820 DDD107498 succinate

DDD107498 succinate; DDD-498 succinate; M5717 succinate

DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.

GC13554 Deferoxamine mesylate

甲磺酸去铁胺; Desferrioxamine B mesylate; DFOM

Deferoxamine mesylate 是一种通过形成稳定的复合物来螯合铁的药物，该复合物可防止铁进入进一步的化学反应，并用于治疗输血依赖性贫血患者的慢性铁过载。

GC15484 Deguelin

鱼藤素; (-)-Deguelin; (-)-cis-Deguelin

A potent antiproliferative rotenoid compound

GC35832 Dehydrocorydaline chloride

盐酸脱氢紫堇碱; 13-Methylpalmatine chloride

An alkaloid with diverse biological activities

GC38528 Dehydropachymic acid

去氢茯苓酸

Dehydropachymic acid 是从茯苓 (Poria cocos) 中分离出的主要三萜类化合物之一。Dehydropachymic acid 在自噬-溶酶体途径 (ALP) 受损细胞比正常细胞中更有效。

GN10529 Demethoxycurcumin

去甲氧基姜黄素; Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin

Natural curcuminoid with roles in cancer and inflammation

GC90700 Dendrogenin A

DDA

一种选择性的LXR调节剂和ChEH抑制剂。

GC38564 Deoxypodophyllotoxin

脱氧鬼臼毒素

A flavolignan with diverse biological activities

GC70636 Desethyl Amiodarone-d4 hydrochloride Desethyl Amiodarone-d4 hydrochloride是氘标记的去乙基胺碘酮盐酸盐。

GC39372 Desethyl chloroquine diphosphate

脱乙基氯喹二磷酸盐

Desethyl chloroquine diphosphate 是 Chloroquine 的主要去乙基代谢产物。Chloroquine 是一种自噬和 toll-like receptors (TLRs) 的抑制剂。Desethyl chloroquine diphosphate 具有抗疟原虫活性。