Autophagy
Autophagy(自噬)
Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.
Autophagy 相关产品(1140)
- GC39411NL-1CAS: 188532-26-5纯度: >98.00%
The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0.9 μM and the Ki for NL-1 site 1 and site 2 was 4.78 and 2.77, respectively.
- GC39450Tea polyphenolCAS: 84650-60-2纯度: >99.00%
Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities.
- GC39530TFEB activator 1CAS: 39777-61-2纯度: >99.50%
TFEB activator 1是一种口服有效、不依赖mTOR的TFEB激活剂，能够显著促进Flag-TFEB的核易位，EC 50 值为2167nM。
- GC39612Imatinib D8CAS: 1092942-82-9
Imatinib D8 (STI571 D8) 是 Imatinib (STI571) 的氘代物。Imatinib 是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL，v-Abl，PDGFR，c-kit 激酶活性。
- GC396584,4'-DimethoxychalconeCAS: 2373-89-9纯度: >98.00%
4,4'-Dimethoxychalcone 可从植物当归中分离得到，是一种天然自噬 (autophagy) 诱导剂，具有抗衰老活性。
- GC40007Malformin ACAS: 3022-92-2纯度: >95.00%
A cyclopentapeptide fungal metabolite with diverse biological activities
- GC40065Meloxicam-d3CAS: 942047-63-4纯度: >99.00%
An internal standard for the quantification of meloxicam
- GC40080Bosutinib-d8CAS: 2733145-45-2纯度: >99.00%
An internal standard for the quantification of bosutinib
- GC40226Curcumin-d6CAS: 1335198-02-1纯度: >99.00%
An internal standard for the quantification of curcumin
- GC40227Indomethacin-d4CAS: 87377-08-0纯度: >99.00%
An internal standard for the quantification of indomethacin
- GC40775DexamethasoneCAS: 50-02-2纯度: >98.00% / >99.00%
地塞米松是糖皮质激素家族的一员，可以保护软骨结构和功能免受关节炎相关变化的影响，包括基质丢失、炎症和软骨活力。
- GC40911Glycine-β-muricholic AcidCAS: 66225-78-3纯度: >95.00% / >98.00%
Glycine-β-muricholic Acid是一种有效的、稳定的、对精氨酸有选择性的口服生物活性FXR抑制剂，是鼠特异性初级胆汁酸β-鼠胆酸的甘氨酸结合形式。
- GC409472,3-Dimethoxy-5-methyl-p-benzoquinoneCAS: 605-94-7纯度: >98.00%
An intermediate in the synthesis of ubiquinones that has anticancer activity
- GC41242Acridine OrangeCAS: 494-38-2纯度: >75.00%
Acridine Orange是一种可穿透细胞的核酸选择性荧光染料， Acridine Orange可与DNA或RNA结合时产生荧光，与双链DNA结合时产生绿色荧光（激发光为488nm；发射光为530nm绿色荧光）。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC39395 | LC3-mHTT-IN-AN1 | 486443-73-6 | - | |
An LC3B-mutant huntingtin linker | ||||
| GC39411 | NL-1 | 188532-26-5 | >98.00% | |
The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0.9 μM and the Ki for NL-1 site 1 and site 2 was 4.78 and 2.77, respectively. | ||||
| GC39450 | Tea polyphenol | 84650-60-2 | >99.00% | |
Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities. | ||||
| GC39481 | BL-918 | 2101517-69-3 | >98.00% | |
An ULK1 activator | ||||
| GC39530 | TFEB activator 1 | 39777-61-2 | >99.50% | |
TFEB activator 1是一种口服有效、不依赖mTOR的TFEB激活剂，能够显著促进Flag-TFEB的核易位，EC 50 值为2167nM。 | ||||
| GC39612 | Imatinib D8 | 1092942-82-9 | - | |
Imatinib D8 (STI571 D8) 是 Imatinib (STI571) 的氘代物。Imatinib 是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL，v-Abl，PDGFR，c-kit 激酶活性。 | ||||
| GC39658 | 4,4'-Dimethoxychalcone | 2373-89-9 | >98.00% | |
4,4'-Dimethoxychalcone 可从植物当归中分离得到，是一种天然自噬 (autophagy) 诱导剂，具有抗衰老活性。 | ||||
| GC40007 | Malformin A | 3022-92-2 | >95.00% | |
A cyclopentapeptide fungal metabolite with diverse biological activities | ||||
| GC40044 | Zymostenol | 566-97-2 | >95.00% | |
A precursor of cholesterol | ||||
| GC40065 | Meloxicam-d3 | 942047-63-4 | >99.00% | |
An internal standard for the quantification of meloxicam | ||||
| GC40080 | Bosutinib-d8 | 2733145-45-2 | >99.00% | |
An internal standard for the quantification of bosutinib | ||||
| GC40226 | Curcumin-d6 | 1335198-02-1 | >99.00% | |
An internal standard for the quantification of curcumin | ||||
| GC40227 | Indomethacin-d4 | 87377-08-0 | >99.00% | |
An internal standard for the quantification of indomethacin | ||||
| GC40484 | Ferulic Acid methyl ester | 2309-07-1 | >99.00% | |
A lipophilic antioxidant | ||||
| GC40685 | Pentoxifylline | 6493-05-6 | >98.00% | |
Pentoxifylline is a methylxanthine derivative. | ||||
| GC40769 | Asperphenamate | 63631-36-7 | >99.50% | |
A fungal secondary metabolite | ||||
| GC40775 | Dexamethasone | 50-02-2 | >98.00% / >99.00% | |
地塞米松是糖皮质激素家族的一员，可以保护软骨结构和功能免受关节炎相关变化的影响，包括基质丢失、炎症和软骨活力。 | ||||
| GC40792 | D-threo Sphinganine (d18:0) | 6036-86-8 | >98.00% | |
A bioactive sphingolipid | ||||
| GC40793 | L-erythro Sphinganine (d18:0) | 6036-76-6 | >98.00% | |
A bioactive sphingolipid | ||||
| GC40861 | Pinosylvin | 22139-77-1 | >99.50% | |
A stilbene with diverse biological activities | ||||
| GC40911 | Glycine-β-muricholic Acid | 66225-78-3 | >95.00% / >98.00% | |
Glycine-β-muricholic Acid是一种有效的、稳定的、对精氨酸有选择性的口服生物活性FXR抑制剂，是鼠特异性初级胆汁酸β-鼠胆酸的甘氨酸结合形式。 | ||||
| GC40947 | 2,3-Dimethoxy-5-methyl-p-benzoquinone | 605-94-7 | >98.00% | |
An intermediate in the synthesis of ubiquinones that has anticancer activity | ||||
| GC41242 | Acridine Orange | 494-38-2 | >75.00% | |
Acridine Orange是一种可穿透细胞的核酸选择性荧光染料， Acridine Orange可与DNA或RNA结合时产生荧光，与双链DNA结合时产生绿色荧光（激发光为488nm；发射光为530nm绿色荧光）。 | ||||
| GC41308 | GPP 78 | 1202580-59-3 | >99.00% | |
Inhibitor of Nampt | ||||