Autophagy(自噬)

Cat.No. 产品名称 Information

GC17685 Sildenafil Citrate

西地那非柠檬酸盐; UK-92480 citrate

A PDE5 inhibitor

GN10292 Silibinin

水飞蓟宾,Silibinin A; Silymarin I

Silibinin是一种具有口服活性的类黄酮，具有保肝和抗癌作用。

GC11455 Silvestrol

(1R,2R,3S,3AR,8BS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-二羟基乙基]-3-甲氧基-1,4-二氧己环-2-基]氧基]-2,3,3A,8B-四氢-1,8B-二羟基-8-甲氧基-3A-(4-甲氧基苯基)-3-苯基-1H-环戊烯并[B]苯并呋喃-2-羧酸甲酯,(-)-Silvestrol

Silvestrol 是一种真核翻译起始因子 4A (eIF4A) 抑制剂，从 Agave americana Linn 中分离出来。Silvestrol 诱导自噬和半胱天冬酶介导的细胞凋亡。

GC10585 Simvastatin (Zocor)

辛伐他汀; MK 733

An HMG-CoA reductase inhibitor

GN10213 Sinomenine Hydrochloride

盐酸青藤碱; Cucoline hydrochloride

Sinomenine Hydrochloride是NF-κB活化的抑制剂。

GC14945 Sirtinol

2-[[(2-羟基-1-萘基)亚甲基]氨基]-N-(1-苯基乙基)苯甲酰胺

Inhibitor of sirtuin deacetylases

GC31317 Sitagliptin (MK0431)

西格列汀; MK-0431

Sitagliptin (MK-0431) is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.

GC12235 Sitagliptin (phosphate)

磷酸西他列汀; MK-0431 phosphate

A DPP-4 inhibitor

GC10298 Sitagliptin phosphate monohydrate

西他列汀磷酸盐一水合物; MK-0431 phosphate monohydrate

Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) 是一种有效的 DPP4 抑制剂，在 Caco-2 细胞提取物中的 IC50 为 19 nM。

GC33229 SJFα SJFα是一种含13个原子连接桥的PROTAC。SJFα降解p38α，DC50为7.16nM，但降解p38δ效果较差(DC50=299nM)，且在浓度高达2.5μM时也不会降解其他p38亚型(β和γ)。

GC33238 SJFδ SJFδ是一种含10个原子连接桥的PROTAC。SJFδ降解p38α，DC50为46.17nM，但不降解其他p38亚型(p38α,p38β和p38γ)。

GC30646 Skatole(3-Methylindole)

粪臭素; 3-Methylindole; 3-Methyl-1H-indole

Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.

GC13578 Skepinone-L

Skepinone L

An inhibitor of p38 MAPK

GC14641 SKF 96365 hydrochloride

1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑

An inhibitor of voltage-gated calcium channels

GC37646 SKF-86002

6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑

An anti-inflammatory agent

GC14272 SMER 28 An enhancer of autophagy

GC34117 SMER18 SMER18是Rapamycin的一种小分子增强剂,充当mTOR非依赖性的的自噬诱导剂。

GN10449 SN-38 (NK012)

7-乙基-10-羟基喜树碱,7-Ethyl-10-hydroxycamptothecin

A potent inhibitor of DNA topoisomerase I

GC13946 SNX-2112

PF-04928473

A potent Hsp90 inhibitor

GC15857 Sodium butyrate

丁酸钠

A short-chain fatty acid and HDAC inhibitor

GN10100 Sodium Danshensu

丹参素钠; Sodium Danshensu; (±)-DanShenSu sodium sal

A salvianolic acid with diverse biological activities

GC15002 Sodium Phenylbutyrate

苯丁酸钠; 4-PBA sodium; 4-Phenylbutyric acid sodium; Benzenebutyric acid sodium

A chemical chaperone

GC12013 Sodium salicylate

水杨酸钠; Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt

水杨酸钠（水杨酸钠盐）抑制环加氧酶 2（COX-2）活性，与转录因子（NF-κB）激活无关。

GC31705 Sofalcone

索法酮

Gastroprotective chalcone derivative

GN10681 Sophocarpine

槐果碱

An alkaloid with diverse biological activities

GC64223 Sophocarpine monohydrate

槐果碱水合物

An alkaloid with diverse biological activities

GC17369 Sorafenib

索拉非尼; Bay 43-9006

索拉非尼Sorafenib是Raf-1和B-Raf的多激酶抑制剂，IC50分别为6 nM和22 nM;Sorafenib对VEGFR-2 VEGFR-3 PDGFR-β Flt-3和c-KIT也有抑制作用，IC50值分别为90 nM、20 nM、57 nM、59 nM和68 nM;索拉非尼能诱导自噬细胞凋亡和激活铁死亡，并具有抗肿瘤活性。