Src

An orally bioavailable tyrosine kinase inhibitor

A selective VEGFR2 inhibitor

Ponatinib (AP24534)是一种多靶点酪氨酸激酶抑制剂，可抑制Abl（IC 50 =0.37nM），PDGFRα（IC 50 =1.1nM），VEGFR2（IC 50 =1.5nM），FGFR1（IC 50 =2.2nM）和Src（IC 50 =5.4nM）的活性。

An inhibitor of tyrosine kinases and Hsp90

Damnacanthal 是一种从海巴戟根中分离出来的蒽醌。

Dasatinib (BMS-354825)是一种高效、口服生物利用度高的多靶点酪氨酸激酶抑制剂，对BCR-ABL、SRC家族激酶、c-KIT和PDGFR-β的IC₅₀分别为0.4nM、0.5nM、100nM和180nM。

A multi-kinase inhibitor

A potent inhibitor of Src kinases

Peptide corresponding to the pp60c-src carboxy terminal regulatory domain

An EGFR receptor tyrosine kinase inhibitor

SU6656是一种小分子吲哚酮类化合物，可选择性抑制Src、Yes和Fyn激酶活性，IC 50 值分别为0.28μM、0.02μM和0.17μM。

KB SRC 4 是一种有效的、高选择性的 c-Src 抑制剂，Ki 为 44 nM，Kd 为 86 nM，对 c-Abl 没有抑制作用，最高可达 125 μM; KB SRC 4 具有抗肿瘤活性。

A multi-kinase inhibitor

CGP 77675是一种高效的酪氨酸激酶Src抑制剂，其抑制纯化Src的自磷酸化反应的IC 50 为40nM。

An inhibitor of Src and p38 MAPK kinases

TPX-0046 is a novel RET/SRC inhibitor with a mean IC50 of 17 nM for RETG810R in Ba/F3 cell proliferation assay

A selective inhibitor of lymphocyte- specific protein tyrosine kinase

AD80, a multikinase inhibitor, shows strong activity against human RET (c-RET), BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.

An inhibitor of Src kinases

PP58是吡啶[2,3-d]嘧啶化合物，抑制PDGFR，FGFR和Src家族活性的IC50值在纳摩尔级。

An inhibitor of c-Src kinase

7-Hydroxychromone is an inhibitor of Src kinase with IC50 of <300 μM.

T338CSrc-IN-1是突变型c-SrcT338C高效抑制剂，IC50值111nM。对WTSrc活性弱10倍以上。

T338CSrc-IN-2是突变型c-Src激酶抑制剂，IC50值317nM，还能抑制T338C/V323A和T338C/V323S双突变Src活性，IC50值57和19nM。