Endogenous Metabolite
Endogenous Metabolite(内源性代谢物)
Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.
Endogenous Metabolite 相关产品(1712)
- GC44635Phosphoenolpyruvic Acid (potassium salt)CAS: 4265-07-0纯度: >99.50% / >99.00%
An enzyme substrate for glycolysis and gluconeogenesis pathways
- GC44680Pregnenolone sulfate (sodium salt)CAS: 1852-38-6纯度: >95.00% / >98.00%
Pregnenolone sulfate (sodium salt)是一种孕烯醇酮的神经活性代谢产物，对氨基丁酸A型受体（GABA A R）的IC 50 值为26±2μmol/L，对不含γ亚基的GABA A R的IC 50 值为18±3μmol/L。
- GC44795Miquelianin (Quercetin 3-O-glucuronide)CAS: 22688-79-5纯度: >99.50% / >98.00%
Miquelianin (Quercetin 3-O-glucuronide)是槲皮素在体内的主要代谢产物，也是羰基还原酶1（CBR1）的抑制剂。
- GC44908sn-Glycerol-3-phosphate (cyclohexyl ammonium salt)CAS: 29849-82-9纯度: >95.00%
A lipid biosynthesis intermediate
- GC44928Sphingomyelins (from bovine spinal cord)CAS: 85187-10-6纯度: >95.00% (natural bovine mixture)
A sphingolipid
- GC44992Taurochenodeoxycholic Acid (sodium salt)CAS: 6009-98-9纯度: >98.00%
Taurochenodeoxycholic Acid (sodium salt)是一种内源性亲水性胆汁酸，是由胆汁酸中的天然成分熊去氧胆酸（UDCA）在肝脏中与氨基酸牛磺酸进行化学结合形成的。Taurochenodeoxycholic Acid (sodium salt)已被批准用于治疗肝脏疾病。Taurochenodeoxycholic Acid (sodium salt)可以减少活性氧的形成，防止线粒体功能障碍，并降低细胞凋亡的阈值。
- GC45031Thiamine (hydrochloride)CAS: 67-03-8纯度: >98.00% / >99.00%
Thiamine (hydrochloride)是一种水溶性必需微量营养素，Thiamine易透过血脑屏障，是研究能量代谢、神经炎症及衰老相关代谢功能障碍的重要工具化合物。
- GC45111UDP-α-D-Glucose (sodium salt)CAS: 28053-08-9纯度: >99.50% / >98.00%
A stereoisomer of UDP-α-D-glucose
- GC45179ZeaxanthinCAS: 144-68-3纯度: >98.00%
Zeaxanthin是一种具有多种生物活性的类胡萝卜素色素，存在于多种水果和蔬菜中，可以帮助治疗或预防与年龄相关的黄斑变性、青光眼和白内障。
- GC45204α-EcdysoneCAS: 3604-87-3纯度: >95.00%
蜕皮激素（α-蜕皮激素）是一种存在于昆虫和植物中的类固醇蜕皮激素，可激活盐皮质激素受体（MR），从而导致肾小球疾病。
- GC45518N1-Acetylspermidine (hydrochloride)CAS: 34450-16-3纯度: >99.50% / >98.00%
N1-Acetylspermidine (hydrochloride)是亚精胺的一种乙酰化衍生物，可作为多胺氧化酶（PAO）的底物。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC44635 | Phosphoenolpyruvic Acid (potassium salt) | 4265-07-0 | >99.50% / >99.00% | |
An enzyme substrate for glycolysis and gluconeogenesis pathways | ||||
| GC44680 | Pregnenolone sulfate (sodium salt) | 1852-38-6 | >95.00% / >98.00% | |
Pregnenolone sulfate (sodium salt)是一种孕烯醇酮的神经活性代谢产物，对氨基丁酸A型受体（GABA A R）的IC 50 值为26±2μmol/L，对不含γ亚基的GABA A R的IC 50 值为18±3μmol/L。 | ||||
| GC44785 | Pyridoxal 5'-phosphate (hydrate) | 853645-22-4 | >95.00% | |
An enzyme cofactor | ||||
| GC44793 | Pyrroloquinoline quinone | 72909-34-3 | >97.00% | |
据报道，吡咯并喹啉醌是一种新的哺乳动物乳酸脱氢酶 (LDH) 辅酶。 | ||||
| GC44795 | Miquelianin (Quercetin 3-O-glucuronide) | 22688-79-5 | >99.50% / >98.00% | |
Miquelianin (Quercetin 3-O-glucuronide)是槲皮素在体内的主要代谢产物，也是羰基还原酶1（CBR1）的抑制剂。 | ||||
| GC44815 | Resolvin D1 | 872993-05-0 | ≥95.00% | |
A product of the action of 15- and 5-LO on DHA | ||||
| GC44867 | SAICAR | 3031-95-6 | >98.00% / >99.00% | |
SAICAR是嘌呤核苷酸从头合成途径中的一种中间代谢产物，SAICAR能够以同工酶选择性的方式激活丙酮酸激酶M2亚型（PKM2；EC 50 =0.3mM）。 | ||||
| GC44908 | sn-Glycerol-3-phosphate (cyclohexyl ammonium salt) | 29849-82-9 | >95.00% | |
A lipid biosynthesis intermediate | ||||
| GC44928 | Sphingomyelins (from bovine spinal cord) | 85187-10-6 | >95.00% (natural bovine mixture) | |
A sphingolipid | ||||
| GC44951 | Stearoyl-L-carnitine (chloride) | 32350-57-5 | >95.00% | |
A long-chain acylcarnitine | ||||
| GC44982 | T-2 Triol | 34114-98-2 | >98.00% | |
An active metabolite of T-2 toxin | ||||
| GC44992 | Taurochenodeoxycholic Acid (sodium salt) | 6009-98-9 | >98.00% | |
Taurochenodeoxycholic Acid (sodium salt)是一种内源性亲水性胆汁酸，是由胆汁酸中的天然成分熊去氧胆酸（UDCA）在肝脏中与氨基酸牛磺酸进行化学结合形成的。Taurochenodeoxycholic Acid (sodium salt)已被批准用于治疗肝脏疾病。Taurochenodeoxycholic Acid (sodium salt)可以减少活性氧的形成，防止线粒体功能障碍，并降低细胞凋亡的阈值。 | ||||
| GC44995 | Taurodeoxycholic Acid (sodium salt) | 1180-95-6 | >98.00% | |
牛磺脱氧胆酸 (TDCA) 是一种胆汁盐，通常存在于肠腔内。 | ||||
| GC45031 | Thiamine (hydrochloride) | 67-03-8 | >98.00% / >99.00% | |
Thiamine (hydrochloride)是一种水溶性必需微量营养素，Thiamine易透过血脑屏障，是研究能量代谢、神经炎症及衰老相关代谢功能障碍的重要工具化合物。 | ||||
| GC45084 | Tridecanoic Acid | 638-53-9 | >98.00% | |
A 13-carbon saturated fatty acid | ||||
| GC45109 | Ubiquinol | 992-78-9 | >90.00% / >95.00% | |
A reduced form of coenzyme Q 10 | ||||
| GC45111 | UDP-α-D-Glucose (sodium salt) | 28053-08-9 | >99.50% / >98.00% | |
A stereoisomer of UDP-α-D-glucose | ||||
| GC45134 | Valeryl-L-carnitine (chloride) | 162040-64-4 | >98.00% | |
A short-chain acylcarnitine | ||||
| GC45179 | Zeaxanthin | 144-68-3 | >98.00% | |
Zeaxanthin是一种具有多种生物活性的类胡萝卜素色素，存在于多种水果和蔬菜中，可以帮助治疗或预防与年龄相关的黄斑变性、青光眼和白内障。 | ||||
| GC45204 | α-Ecdysone | 3604-87-3 | >95.00% | |
蜕皮激素（α-蜕皮激素）是一种存在于昆虫和植物中的类固醇蜕皮激素，可激活盐皮质激素受体（MR），从而导致肾小球疾病。 | ||||
| GC45245 | (-)-Caryophyllene oxide | 1139-30-6 | >98.00% | |
A bicyclic sesquiterpene | ||||
| GC45339 | 3-Oxocholic Acid | 2304-89-4 | >98.00% | |
A secondary bile acid | ||||
| GC45518 | N1-Acetylspermidine (hydrochloride) | 34450-16-3 | >99.50% / >98.00% | |
N1-Acetylspermidine (hydrochloride)是亚精胺的一种乙酰化衍生物，可作为多胺氧化酶（PAO）的底物。 | ||||
| GC45673 | 7,8-Dihydroneopterin | 1218-98-0 | >85.00% | |
An antioxidant | ||||