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Home >> Signaling Pathways >> Proteases >> Endogenous Metabolite

Endogenous Metabolite(内源性代谢物)

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Products for  Endogenous Metabolite

  1. Cat.No. 产品名称 Information
  2. GC31316 H-Phe-Phe-OH

    L-苯丙氨酸-L-苯丙氨酸

     H-Phe-Phe-OH (Phenylalanyl-phenylalanine, Phe-Phe, L-Phe-L-Phe) is a short peptide diphenylalanine with utility for potential applications in biomaterial chemistry, sensors and bioelectronics.
  3. GC31307 4-Methyl-2-oxopentanoic acid

    4-甲基-2-氧代戊酸,α-Ketoisocaproic acid

    4-Methyl-2-oxopentanoic acid是一种异常代谢物、神经毒素和代谢毒素。4-Methyl-2-oxopentanoic acid通过损害 mTOR 和自噬信号通路，增加内质网应激，促进前脂肪细胞脂质积累和胰岛素抵抗。
  4. GC31290 3-Indolepropionic acid

    吲哚-3-丙酸,Indole-3-propionic acid; 3-IPA

     A bacterial metabolite with antioxidant and neuroprotective activities
  5. GC31282 p-Hydroxybenzaldehyde

    对羟基苯甲醛

     p-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol), which can be found in the orchids Gastrodia elata, Galeola faberi and vanilla, is a hydroxybenzaldehyde that reacts with NAD+ and H2O to produce 4-hydroxybenzoate, NADH, and 2 protons. p-Hydroxybenzaldehyde at 101.7 μM can significantly reduce the GABA-induced chloride current of GABAA receptors(α1β2γ2S subtype) expressed.
  6. GC31253 Palmitoleic acid

    棕榈油酸；(Z)-Hexadec-9-enoic acid

     Palmitoleic acid是一种omega-7单不饱和脂肪酸，在澳洲坚果植物中含量很高。
  7. GC31241 D-Arabitol

    D-阿拉伯糖醇

     A fungal metabolite
  8. GC31240 Stearoylethanolamide

    N-(2-羟基乙基)硬脂酰胺,Ceramid, Stearic Acid Ethanolamide

     An endocannabinoid
  9. GC31223 Tyramine

    酪胺

     A monoamine and TAAR1 agonist
  10. GC31222 2-Hydroxy-3-methylbutanoic acid

    2-羟基-3-甲基丁酸

     2-Hydroxy-3-methylbutanoic acid (3-Methyl-2-hydroxybutyric acid, 2-Hydroxyisopentanoic acid, 2-Oxyisovaleric acid) is a metabolite found in the urine of patients with phenylketonuria, methylmalonic acidemia, propionic acidemia, 3-ketothiolase deficiency, isovaleric acidemia, 3-methylcrotonylglycemia, 3-hydroxy-3-methylglutaric acidemia, multiple carboxylase deficiency, glutaric aciduria, ornithine transcarbamylase deficiency, glyceroluria, tyrosinemia type I, galactosemia, and maple syrup urine disease.
  11. GC31219 8-Hydroxyguanosine

    8-羟基鸟苷

     An oxidized nucleoside and a marker of RNA oxidative damage
  12. GC31210 Paraxanthine

    1,7-二甲基黄嘌呤

     An active metabolite of caffeine
  13. GC31186 Citicoline sodium salt

    胞磷胆碱钠; Cytidine diphosphate-choline sodium; CDP-Choline sodium; Cytidine 5'-diphosphocholine sodium

     Citicoline sodium salt是胞磷胆碱的水溶性形式，胞磷胆碱是磷脂酰胆碱合成过程中的天然中间体，作为乙酰胆碱和磷脂酰胆碱在大脑中的前体，具有抑制活性氧（ROS）产生和细胞凋亡的生物学功能。
  14. GC31180 Royal Jelly acid (Queen Bee Acid)

    王浆酸; Queen Bee Acid; (E)-10-Hydroxy-2-decenoic acid

     An unsaturated fatty acid found in royal jelly
  15. GC30872 Pipecolic acid

    六氢吡啶-alpha-羧酸；哌啶-2-甲酸；呢可酸；2-哌啶甲酸

     Pipecolic acid (piperidine-2-carboxylic acid), a metabolite of lysine found in human physiological fluids such as urine, plasma and CSF, is an important regulator of immunity in plants and humans alike.
  16. GC30842 Androsterone (5α-Androstan-3α-ol-17-one)

    雄酮; 5α-Androstan-3α-ol-17-one

     Androsterone (5α-Androstan-3α-ol-17-one)是睾酮的一种代谢产物，可调节癫痫发作的易感性。
  17. GC30806 Cyclo(his-pro) (Cyclo(histidyl-proline))

    环(组氨酰-脯氨酰),Cyclo(histidyl-proline); Histidylproline diketopiperazine

     Cyclo(his-pro) (Cyclo(histidyl-proline))是一种内源性、可透过血脑屏障的环状二肽，来源于促甲状腺激素释放激素（TRH）的分解代谢。
  18. GC30795 D-Galactose (D-(+)-Galactose)

    D-半乳糖; D-(+)-Galactose

    A natural aldohexose
  19. GC30775 Histamine (Ergamine)

    组胺; Ergamine

    A biogenic amine
  20. GC30767 Heparan Sulfate

    硫酸乙酰肝素

    硫酸乙酰肝素 (HS) 是一种复杂的聚阴离子多糖，广泛表达于细胞表面和细胞外基质。
  21. GC30765 Docosahexaenoic Acid (DHA)

    二十二碳六烯酸; DHA; Cervonic acid

     二十二碳六烯酸 (DHA) 是一种长链多不饱和脂肪酸，对婴儿和成人均有活性。
  22. GC30760 Pentadecanoic acid

    十五烷酸

     A saturated fatty acid
  23. GC30758 m-Coumaric acid

    3-羟基肉桂酸

     m-Coumaricacid是来自咖啡酸的多酚代谢物，由肠道微生物群形成，体液中的量是饮食依赖性的。
  24. GC30757 DL-Homocysteine thiolactone hydrochloride

    DL-高半胱氨酸硫内酯盐酸盐

     A derivative of DL-homocysteine
  25. GC30753 Ureidopropionic acid

    3-酰脲丙酸,3-Ureidopropionic acid

     Ureidopropionic acid is an intermediate in the metabolism of uracil.
  26. GC30749 1,3-Dimethyluric acid

    1,3-二甲基尿酸

     1,3-二甲基尿酸（1,3-Dimethyluric acid）是一种氧嘌呤，它是 7,9-二氢-1H-嘌呤-2,6,8(3H)-三酮，在 N-1 和 N-3 被甲基取代。是人体茶碱代谢的产物。1,3-二甲基尿酸是尿路结石中的嘌呤成分之一。
  27. GC30745 L-Palmitoylcarnitine

    棕榈酰肉碱

     L-Palmitoylcarnitine 是一种重要的内源性脂肪酸代谢物，可同时提高离子通道对 ATP 的敏感性，IC50 值在 30.3 ± 5.5µM和62.0 ± 2.7之间。
  28. GC30744 Norepinephrine (Adrenor)

    去甲肾上腺素; Levarterenol; L-Noradrenaline

    (-)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
  29. GC30742 1,3-Diaminopropane 1,3-Diaminopropane是一种三碳二胺，是鸟氨酸脱羧酶抑制剂。
  30. GC30735 (S)-Leucic acid

    (S)-2-羟基-4-甲基戊酸

     Leucic acid ((S)-α-hydroxyisocaproic acid) is a metabolite of the branched chain amino acid known as leucine, which plays a significant role in the synthesis of muscle protein.
  31. GC30732 Guanosine (DL-Guanosine)

    鸟嘌呤核苷; 鸟苷; DL-Guanosine; Vernine

    A purine nucleoside
  32. GC30730 Monoisobutyl phthalic acid

    苯二甲酸单异丁酯

     Monoisobutylphthalicacid是一种邻苯二甲酸酯代谢物，存在于人的精液和肽粪中。
  33. GC30729 3-Hydroxyvaleric acid

    3-羟基戊酸

    3-Hydroxyvalericacid是一种五碳酮体。3-Hydroxyvalericacid可以发生回补反应，即可以补充三羧酸循环的中间产物。
  34. GC30728 Isobutyryl-L-carnitine

    异丁酰-L-肉碱

     An acylcarnitine
  35. GC30727 Beta-Cortol

    NSC 58792

     An endogenous metabolite of cortisol
  36. GC30726 Eicosadienoic acid

    二十碳二烯酸

     Eicosadienoic acid能够抑制小鼠5'-单磷酸肌苷脱氢酶（IMPDH）的活性，并且与IMPDH的结合具有竞争性（Ki=3.1μM）。
  37. GC30724 trans-Vaccenic acid

    反式-11-十八烯酸

     trans-Vaccenic acid是一种单不饱和脂肪酸，是反刍动物来源的脂质中最主要的一种反式异构体。
  38. GC30723 Ubiquinone-1

    辅酶Q1

     Ubiquinone-1是辅酶Q合成过程中的中间体。
  39. GC30722 Anserine

    L-鹅肌肽

     Anserine (β-alanyl-N-methylhistidine) is a dipeptide containing β-alanine and 1-methylhistidine. It is normally absent from human tissues and body fluids, and its appearance there is an artifact of diet and serum carnosinase deficiency.
  40. GC30720 2-Naphthol

    β-萘酚

     2-Naphthol (2-Hydroxynaphthalene, 2-Naphthalenol, beta-Naphthol, Naphth-2-ol, β-naphthol), a potential antinematodal drug, is a widely used intermediate for the production of dyes and other compounds.
  41. GC30719 3-Amino-4-methylpentanoic acid

    3-氨基-4-甲基戊酸

     3-Amino-4-methylpentanoic acid (beta-Leucine, DL-Homovaline, DL-beta-leucine, beta-Aminoisocaproic acid) is a human metabolite.
  42. GC30718 2-Amino-1-phenylethanol

    2-氨基-1-苯乙醇

     2-Amino-1-phenylethanol (2-APE) is a noradrenaline analogue.
  43. GC30716 Levulinic acid (4-Oxovaleric acid)

    乙酰丙酸; 4-Oxovaleric acid; NSC 3716

     Levulinic acid (4-oxopentanoic acid, β-Acetylpropionic acid, 3-Acetopropionic acid, γ-ketovaleric acid) is used as a precursor for pharmaceuticals, plasticizers, and various other additives.
  44. GC30715 Guanosine 5'-diphosphate

    鸟苷-5ˊ-二磷酸二钠盐(酵母),GDP

     Guanosine 5'-diphosphate作为一种关键的核苷二磷酸，通过G蛋白信号转导作为细胞内信号级联反应的调节剂。
  45. GC30713 2-Oxovaleric acid

    2-戊酮酸

    2-Oxovalericacid是在人体血液中发现的一种酮酸。
  46. GC30712 5-Methoxytryptophol

    5-甲氧基色醇

     A natural indole
  47. GC30711 D-Threitol

    D-苏糖醇

    D-threitol可以作为阿拉斯加甲虫的防冻剂。
  48. GC30708 Terephthalic acid

    对苯二甲酸

    Terephthalic acid (para-Phthalic acid, 1,4-Benzenedioic acid), a raw material for polyethylene terephthalate (PET) production, is one of the most important chemicals in petrochemical industry.
  49. GC30707 DL-Dopa

    DL-多巴

     DL-Dopa (3,4-Dihydroxy-DL-phenylalanine) is an immediate precursor of dopamine.
  50. GC30706 Maltotriose

    麦芽三糖

     A trisaccharide
  51. GC30704 Urocanic acid

    尿刊酸

    Urocanic acid is an intermediate in the catabolism of L-histidine.

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