GlpBio

Cathepsin

Cathepsin(组织蛋白酶)

Cathepsins (the term standing for “lysosomal proteolytic enzyme”) are a class of globular proteases that catalyze the hydrolysis of intracellular peptides and also exhibit extracellular functions. So far, a total of sixteen members of human cathepsin family have been identified, which are divided into three subfamilies, including cysteine protease family (cathepsin B, C, F, H, L, K, O, S, V, W, X and Z), serine carboxypeptidase family (cathepsin A and G) and aspartic protease family (cathepsin D and E). Cathepsins are highly expressed in various human cancers with each member playing different roles in distinct tumorigenic processes, including proliferation, angiogenesis, metastasis and invasion.

Cathepsin 相关产品(65)

  • GC72712 structure
    GC72712Z-FG-NHO-BzOME
    CAS: 180313-86-4
    纯度: >98.00%

    Z-FG-NHO-BzOME是一种半胱氨酸蛋白酶抑制剂，选择性抑制组织蛋白酶B、组织蛋白酶L、组织蛋白酶S和木瓜蛋白酶。

  • GC73242 structure
    GC73242LN5P45
    纯度: >99.00%

    LN5P45是OTUB2抑制剂（IC50: 2.3 μM）。

  • GC73677 structure
    GC73677Olgotrelvir sodium
    CAS: 2763596-72-9
    纯度: >95.00%

    Olgotrelvir sodium是一种口服活性的冠状病毒主要蛋白酶（Mpro）和人细胞组织蛋白酶（cathepsin L）的双重抑制剂。

  • GC73810 structure
    GC73810Z-Arg-Arg-βNA acetate
    CAS: 2237216-27-0
    纯度: 不显示

    Z-Arg-Arg-βNA acetate是蛋白酶组织蛋白酶B的敏感二肽底物，对蛋白酶H和L具有抗性。

  • GC74001 structure
    GC74001TS-24
    CAS: 1563260-97-8
    纯度: >98.00%

    TS-24是组织蛋白酶S的抑制剂，IC50为4.3μM。

  • GC74379 structure
    GC74379Arg-Arg-AMC acetate
    纯度: >98.00%

    Arg-Arg-AMC acetate是Arg-Arg-AMC的醋酸盐形式。

  • GP26142 structure
    GP26142CTSF Human, Sf9

    CTSF produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 474 amino acids (20-484

  • GP26143 structure
    GP26143CTSZ Mouse, Active

    CTSZ Mouse Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 292 amino acids (23-306 aa) and having a molecular mass of32

  • GC13787 structure
    GC13787E 64d
    CAS: 88321-09-9
    纯度: >99.50%

    E 64d是一种可渗透细胞的不可逆的广谱半胱氨酸蛋白酶抑制剂，具有抑制血小板聚集的活性。

  • GC15917 structure
    GC15917CA-074 Me
    CAS: 147859-80-1
    纯度: >99.00% / >98.00%

    CA-074 Me（CA-074甲酯）是组织蛋白酶B（CB）的特异性抑制剂。

  • GC16317 structure
    GC16317CA 074
    CAS: 134448-10-5
    纯度: >99.50% / >98.00%

    CA 074是一种选择性组织蛋白酶B抑制剂，K i 值为2-5nM， CA 074对纯化的大鼠组织蛋白酶B的抑制作用比对组织蛋白酶H和L的抑制作用强10000-30000倍。

  • GC10376 structure
    GC10376Cathepsin G Inhibitor I
    CAS: 429676-93-7
    纯度: >95.00%

    Cathepsin G Inhibitor I 是一种有效的、选择性的、可逆的、竞争性的、非肽的组织蛋白酶 G 抑制剂。

  • GC14903 structure
    GC14903Cathepsin S inhibitor
    CAS: 1373215-15-6
    纯度: >98.00%

    A potent cathepsin S inhibitor

  • GC16388 structure
    GC16388Odanacatib (MK-0822)
    CAS: 603139-19-1
    纯度: >98.00%

    Odanacatib (MK-0822)是一种具有口服活性的组织蛋白酶K（Cathepsin K）抑制剂。

  • GC17989 structure
    GC17989L 006235
    CAS: 294623-49-7
    纯度: >99.50%

    An inibitor of cathepsin K

  • GC11640 structure
    GC11640MDL 28170
    CAS: 88191-84-8
    纯度: >97.00%

    MDL 28170是一种细胞渗透性、可逆的肽醛类抑制剂，可抑制钙蛋白酶（K i =0.01μM；对组织蛋白酶B的K i =0.025μM）。

  • GC10377 structure
    GC10377SID 26681509
    CAS: 958772-66-2
    纯度: >98.00%

    SID 26681509 是一种有效的、可逆的、竞争性的、选择性的人组织蛋白酶 L 抑制剂，IC50 为 56 nM。