Acyltransferase
Acyltransferase(酰基转移酶)
DGAT (acyl-CoA: diacylglycerol acyltransferase) is a transmembrane enzyme that acts in the final and committed step of triacylglycerides (TAGs) synthesis, and it has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT catalyzes the acylation of sn-1,2-diacylglycerol (DAG) at the sn-3 position using an acyl-CoA substrate. DGAT has been proposed to be the rate-limiting enzyme in plant storage lipid accumulation. DGAT is considered a key enzyme for biotechnological purposes; it might be utilized to increase oil content in oleaginous plant species.
DGAT1 and DGAT2 are two of the enzymes that are responsible for the main part of TAG synthesis in most organisms, and they have been studied in many eukaryotic organisms.
Acyltransferase 相关产品(63)
- GC316322-Furoic acid (Furan-2-carboxylic acid)CAS: 88-14-2纯度: >98.00%
2-Furoic acid (2-Furancarboxylic acid, Pyromucic acid, 2-Carboxyfuran, α-furancarboxylic acid, α-furoic acid) is an organic compound most widely found in food products as a preservative and a flavoring agent.
- GC32488K-604 dihydrochlorideCAS: 217094-32-1纯度: >98.00%
K-604 dihydrochloride, a potent and selective inhibitor of Acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1), suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels.
- GC32613RP-64477CAS: 135239-65-5纯度: >99.50%
RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). RP-64477 inhibits ACAT activity with IC50 of 113 nM, 503 nM, and 180 nM in human intestinal (CaCo-2), hepatic (HepG2) and monocytic (THP-1) cell assays, respectively.
- GC33808Diacylglycerol acyltransferase inhibitor-1CAS: 1610800-25-3
Diacylglycerolacyltransferaseinhibitor-1是一个二酰基甘油酰基转移酶(DGAT1)抑制剂。
- GC3888110,12-Tricosadiynoic acidCAS: 66990-30-5纯度: >99.00%
10,12-Tricosadiynoic acid是一种具有高效特异性、选择性和口服活性的酰基辅酶A氧化酶-1（ACOX1）抑制剂。
- GC43490DL-Glyceraldehyde-3-phosphateCAS: 591-59-3纯度: >98.00%
DL-甘油醛-3-磷酸是冬氨酸氨基转移酶阳离子和阴离子同工酶的一种时间依赖性抑制剂。
- GC47160Cystamine-d8 (hydrochloride)CAS: 2712126-51-5纯度: >99.00%
A neuropeptide with diverse biological activities
- GC48062RU-SKI 201 (hydrochloride)CAS: 2320262-09-5纯度: >95.00%
A neuropeptide with diverse biological activities
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC31551 | FR-190809 | 215589-63-2 | - | |
FR-190809是一种有效、可口服、无肾上腺毒性的酰基辅酶A-胆固醇酰基转移酶(ACAT)抑制剂，IC50值为45nM。 | ||||
| GC31555 | MGAT2-IN-2 | 1710630-11-7 | - | |
MGAT2-IN-2是一种有效的选择性酰基辅酶A:单酰甘油酰基转移酶2(MGAT2)抑制剂，IC50为3.4nM。 | ||||
| GC31632 | 2-Furoic acid (Furan-2-carboxylic acid) | 88-14-2 | >98.00% | |
2-Furoic acid (2-Furancarboxylic acid, Pyromucic acid, 2-Carboxyfuran, α-furancarboxylic acid, α-furoic acid) is an organic compound most widely found in food products as a preservative and a flavoring agent. | ||||
| GC32488 | K-604 dihydrochloride | 217094-32-1 | >98.00% | |
K-604 dihydrochloride, a potent and selective inhibitor of Acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1), suppresses the development of atherosclerosis in an animal model without affecting plasma cholesterol levels. | ||||
| GC32613 | RP-64477 | 135239-65-5 | >99.50% | |
RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). RP-64477 inhibits ACAT activity with IC50 of 113 nM, 503 nM, and 180 nM in human intestinal (CaCo-2), hepatic (HepG2) and monocytic (THP-1) cell assays, respectively. | ||||
| GC33808 | Diacylglycerol acyltransferase inhibitor-1 | 1610800-25-3 | - | |
Diacylglycerolacyltransferaseinhibitor-1是一个二酰基甘油酰基转移酶(DGAT1)抑制剂。 | ||||
| GC35221 | ABT-046 | 1031336-60-3 | >98.50% | |
ABT-046 是一种具有口服活性的选择性二酰基甘油酰基转移酶 1 (DGAT-1) 抑制剂，IC50 为 8 nM。 | ||||
| GC35850 | DGAT-1 inhibitor 2 | 942999-61-3 | >98% / >95% | |
DGAT-1 inhibitor 2是有效的DGAT-1抑制剂，具有减肥功效。 | ||||
| GC35851 | DGAT1-IN-1 | 1449779-49-0 | - | |
DGAT1-IN-1是高效DGAT1抑制剂，IC50值低于10nM（Hep3B细胞过表达DGAT1裂解物测得）。 | ||||
| GC38636 | Glabrol | 59870-65-4 | >99.50% | |
Glabrol (Compound 1) 是从甘草根的乙醇提取物中分离得到的一种异戊二烯类黄酮，是一种有效且非竞争性的 ACAT (酰基辅酶 A:胆固醇酰基转移酶)抑制剂，对大鼠肝脏微粒体 ACAT 的 IC50 值为 24.6 μM。 | ||||
| GC38881 | 10,12-Tricosadiynoic acid | 66990-30-5 | >99.00% | |
10,12-Tricosadiynoic acid是一种具有高效特异性、选择性和口服活性的酰基辅酶A氧化酶-1（ACOX1）抑制剂。 | ||||
| GC40101 | IMP-1088 | 2059148-82-0 | >95.00% | |
IMP-1088是一种针对人类N-豆蔻酰转移酶NMT1和NMT2的皮摩尔级双重抑制剂，对NMT1的IC 50 值为0.24nM，对NMT2的IC 50 值 < 1nM。 | ||||
| GC41638 | TSI-01 | 704878-75-1 | >95.00% / >98.00% | |
TSI-01是溶血磷脂酰胆碱酰基转移酶2（LPCAT2）的选择性抑制剂，对人 LPCAT2和LPCAT1的IC 50 值分别为0.47和3.02μM。 | ||||
| GC42806 | Andrastin A | 174232-42-9 | >95.00% | |
A meroterpenoid farnesyltransferase inhibitor | ||||
| GC43192 | CAY10685 | 1613116-16-7 | >98.00% | |
A “clickable” analog of CPTH2 | ||||
| GC43490 | DL-Glyceraldehyde-3-phosphate | 591-59-3 | >98.00% | |
DL-甘油醛-3-磷酸是冬氨酸氨基转移酶阳离子和阴离子同工酶的一种时间依赖性抑制剂。 | ||||
| GC43609 | Enniatin A | 2503-13-1 | >99.00% | |
A component of the enniatin complex | ||||
| GC43611 | Enniatin B1 | 19914-20-6 | >99.00% | |
An antibiotic ionophore | ||||
| GC43709 | Fumonisin B2 | 116355-84-1 | >98.00% | |
A mycotoxin | ||||
| GC46023 | Phenylpyropene A | 189564-20-3 | >95.00% | |
A fungal metabolite | ||||
| GC47160 | Cystamine-d8 (hydrochloride) | 2712126-51-5 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC48062 | RU-SKI 201 (hydrochloride) | 2320262-09-5 | >95.00% | |
A neuropeptide with diverse biological activities | ||||
| GC49457 | Oleoyl-Coenzyme A (sodium salt) | - | >95.00% / >90.00% / >70.00% | |
酰基辅酶A硫酯 | ||||
| GC50570 | ST 045849 | 442665-87-4 | >98.50% | |
ST 045849是一种O-GlcNAc转移酶(OGT)抑制剂，IC 50 值为53μM。 | ||||