GlpBio

Akt

Akt 相关产品(122)

  • GC34053 structure
    GC34053SOLENOPSIN
    CAS: 137038-57-4

    Solenopsin是一种ATP-竞争型AKT抑制剂，withIC50值为10μM.

  • GC35037 structure
    GC350371,3-Dicaffeoylquinic acid
    CAS: 19870-46-3
    纯度: >98.50%

    1,3-Dicaffeoylquinic acid能抑制HIV-1整合酶的3'端加工、末端连接以及解体过程，IC 50 值分别为0.35、0.56和0.84μg/ml。

  • GC35212 structure
    GC35212A-674563 hydrochloride
    CAS: 2070009-66-2
    纯度: >98.00%

    An Akt inhibitor

  • GC35242 structure
    GC35242Actein
    CAS: 18642-44-9
    纯度: >98.50%

    Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖，诱导自噬和凋亡。Actein 在体内几乎没有毒性。

  • GC35275 structure
    GC35275AKT-IN-3
    CAS: 2374740-21-1

    AKT-IN-3 (compound E22) 是一种有效、口服的低 hERG 阻断 Akt 抑制剂，对 Akt1、Akt2 和 Akt3 作用的 IC50 值分别为 1.4 nM、1.2 nM 和 1.7 nM。AKT-IN-3 (compound E22) 对其他 AGC 家族激酶也有较好的抑制活性，如 PKA、PKC、ROCK1、RSK1、P70S6K、SGK。AKT-IN-3 (compound E22) 能诱导癌细胞凋亡，抑制癌细胞的转移。

  • GC35395 structure
    GC35395Arnicolide D
    CAS: 34532-68-8
    纯度: >98.00%

    A sesquiterpene lactone with anticancer activity

  • GC35651 structure
    GC35651Cenisertib
    CAS: 871357-89-0
    纯度: >99.50%

    Cenisertib (AS-703569) 是一种多激酶抑制剂，可抑制 Aurora-kinase-A/B，ABL1，AKT，STAT5, FLT3 的活性。 Cenisertib 通过抑制肿瘤肥大细胞 (MC) 中几种不同分子靶标的活性抑制其生长。 Cenisertib 抑制异种移植模型中胰腺癌，乳腺癌，结肠癌，卵巢癌和肺癌以及白血病的肿瘤生长。

  • GC35747 structure
    GC35747Crebanine
    CAS: 25127-29-1
    纯度: >99.50%

    An aporphine alkaloid with diverse biological activities

  • GC36447 structure
    GC36447Licochalcone E
    CAS: 864232-34-8
    纯度: >99.50%

    Licochalcone E 是可从Glycyrrhiza inflate 中提取到的黄酮类化合物，通过抑制AKT 和 MAPK 的激活来抑制NF-κB 和 AP-1 的转录活性。

  • GC36456 structure
    GC36456Licoricidin
    CAS: 30508-27-1

    Licoricidin (LCD) 从甘草 Glycyrrhiza uralensis Fisch 中分离，具有抗癌活性。Licoricidin (LCD) 通过诱导周期停滞，诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)，是一种对抗结直肠癌的潜在化学预防或化学治疗剂。Licoricidin (LCD) 通过抑制肿瘤血管生成和淋巴管生成以及肿瘤组织局部微环境的变化抑制肺转移。Licoricidin (LCD) 通过体外和体内 Akt 和 NF-κB 途径的失活，增强吉西他滨诱导的骨肉瘤 (OS) 细胞的细胞毒性。Licoricidin (LCD) 通过 ROS 清除阻断 UVA 诱导的光老化，限制 MMP-1 的活性，被认为是新的局部应用的抗衰老制剂中的活性成分。

  • GC36855 structure
    GC36855Paris saponin VII
    CAS: 68124-04-9
    纯度: >98.00% / >98.50%

    Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.

  • GC37859 structure
    GC37859Uprosertib hydrochloride
    CAS: 1047635-80-2

    A selective Akt inhibitor

  • GC37954 structure
    GC37954YS-49
    CAS: 132836-42-1
    纯度: >98.50%

    An inhibitor of platelet aggregation

  • GC37955 structure
    GC37955YS-49 monohydrate
    纯度: >99.50%

    An inhibitor of platelet aggregation

  • GC38088 structure
    GC38088Hederacolchiside A1
    CAS: 106577-39-3
    纯度: >99.50%

    Hederacolchiside A1 是从白头翁中分离的，通过调节 PI3K/Akt/mTOR 信号通路诱导凋亡，从而抑制肿瘤细胞的增殖。Hederacolchiside A1 具有抗血吸虫病活性，影响体内和体外的寄生虫生存力。

  • GC38170 structure
    GC38170Phellodendrine
    CAS: 6873-13-8
    纯度: >99.50%

    An alkaloid with diverse biological activities

  • GC38236 structure
    GC38236Esculetin
    CAS: 305-01-1
    纯度: >99.00%

    A coumarin with diverse actions

  • GC38419 structure
    GC38419Cyclovirobuxine D
    CAS: 860-79-7

    An alkaloid with diverse biological activities

  • GC38606 structure
    GC38606Glaucocalyxin A
    CAS: 79498-31-0
    纯度: >99.00%

    Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells.

  • GC38609 structure
    GC38609Rotundic acid
    CAS: 20137-37-5
    纯度: >98.00%

    Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.

  • GC38679 structure
    GC38679Urolithin B
    CAS: 1139-83-9
    纯度: >99.50%

    A metabolite of ellagic acid

  • GC39266 structure
    GC39266Hematein
    CAS: 475-25-2
    纯度: >65.00%

    Hematein inhibits casein kinase II activity in a selective, dose-dependent and ATP non-competitive manner in vitro, with IC50 of 0.55 μM in the presence of 10 μM ATP.

  • GC39715 structure
    GC39715M2698
    CAS: 1379545-95-5
    纯度: >99.50%

    A dual inhibitor of p70S6K and Akt1

  • GC41573 structure
    GC41573Theaflavin 3,3'-digallate
    CAS: 30462-35-2
    纯度: >98.00%

    Theaflavin 3,3'-digallate（茶黄素-3,3'-双没食子酸; TF-3; ZP10）是一种有效的寨卡病毒（ZIKV）蛋白酶抑制剂，IC 50 值为2.3μM。