GlpBio

Akt

Akt 相关产品(122)

  • GC16366 structure
    GC16366AKT Kinase Inhibitor
    CAS: 842148-40-7
    纯度: >99.50% / >99.00% / >98.00%

    AKT Kinase Inhibitor是一种具有抗肿瘤活性的Akt激酶抑制剂。

  • GC16475 structure
    GC16475Afuresertib
    CAS: 1047644-62-1
    纯度: >99.50%

    A pan-Akt inhibitor

  • GC17500 structure
    GC17500SU6656
    CAS: 330161-87-0

    SU6656是一种小分子吲哚酮类化合物，可选择性抑制Src、Yes和Fyn激酶活性，IC 50 值分别为0.28μM、0.02μM和0.17μM。

  • GC17658 structure
    GC17658Guggulsterone
    CAS: 95975-55-6
    纯度: >99.50%

    Guggulsterone是一种从植物Commiphora wightii的树脂中提取的植物甾醇。Guggulsterone可以抑制多种肿瘤细胞的生长，并通过下调抗凋亡基因产物（IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP和survivin）、调节细胞周期蛋白（如Cyclin D1和c-Myc）、激活半胱氨酸蛋白酶、抑制Akt以及激活JNK来诱导细胞凋亡。

  • GC17963 structure
    GC17963CHPG Sodium salt
    CAS: 1303993-73-8
    纯度: >99.00%

    CHPG 钠盐是一种选择性 mGluR5 激动剂，可通过 BV2 小胶质细胞中的 TSG-6/NF-κB 通路减弱 SO2 诱导的氧化应激和炎症。

  • GC17984 structure
    GC17984FPA 124
    CAS: 902779-59-3
    纯度: >95.00%

    A cell-permeable Akt inhibitor

  • GC18374 structure
    GC18374API-1
    CAS: 36707-00-3

    An Akt inhibitor

  • GC19036 structure
    GC19036ARQ-092
    CAS: 1313881-70-7
    纯度: >99.00%

    An orally bioavailable pan-Akt inhibitor

  • GC19484 structure
    GC19484BAY1125976
    CAS: 1402608-02-9
    纯度: >99.50%

    An allosteric inhibitor of Akt1/2

  • GC19540 structure
    GC19540α-Linolenic Acid
    CAS: 463-40-1
    纯度: >98.00% / >99.00% / >99.50%

    An essential ω-3 polyunsaturated fatty acid

  • GC25638 structure
    GC25638Miransertib (ARQ 092) HCl
    CAS: 1313883-00-9

    Miransertib (ARQ 092) HCl is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors.

  • GC30582 structure
    GC30582Crosstide
    CAS: 171783-05-4

    A peptide substrate for Akt

  • GC30770 structure
    GC30770LM22B-10
    CAS: 342777-54-2
    纯度: >98.00%

    An activator of TrkB and TrkC

  • GC31536 structure
    GC31536N-Oleoyl glycine
    CAS: 2601-90-3
    纯度: >98.00%

    A putative substrate for peptidyl glycine α- amidating enzyme

  • GC32254 structure
    GC32254Deltonin
    CAS: 55659-75-1
    纯度: >99.50%

    Deltonin是从盾叶薯蓣中得到的甾体皂苷，能够抑制ERK1/2和AKT的活化，具有抗肿瘤的活性。

  • GC32510 structure
    GC32510Loureirin A
    CAS: 119425-89-7
    纯度: >99.50%

    Loureirin A is a flavonoid extracted from the red resin of the herbs of Dracaena cochinchinensis, which is known as Dragon's Blood. Loureirin A inhibits platelet activation by an impairment of PI3K/Akt signaling. Loureirin A inhibits Akt phosphorylation.

  • GC32794 structure
    GC32794Ipatasertib dihydrochloride (GDC-0068 (dihydrochloride))
    CAS: 1396257-94-5
    纯度: >99.00%

    A pan-Akt inhibitor

  • GC32892 structure
    GC32892PF-AKT400 (AKT protein kinase inhibitor)
    CAS: 1004990-28-6
    纯度: >98.00%

    PF-AKT400（AKT 蛋白激酶抑制剂）是一种广泛选择性、强效、ATP 竞争性 Akt 抑制剂，对 PKBα 的选择性高出 900 倍； (IC50=0.5 nM) 比 PKA (IC50=450 nM)。

  • GC32939 structure
    GC32939Akt1 and Akt2-IN-1
    CAS: 893422-47-4
    纯度: >99.00%

    Akt1andAkt2-IN-1是一种有效的变构抑制剂,抑制Akt1(IC50=3.5nM)和Akt2(IC50=42nM)。

  • GC33010 structure
    GC33010GSK2110183 hydrochloride
    CAS: 2070009-64-0
    纯度: >99.00%

    GSK2110183 hydrochloride 是 GSK2110183 的结构类似物。

  • GC33130 structure
    GC33130Recilisib (Ex-RAD)
    CAS: 334969-03-8
    纯度: >98.00%

    Recilisib (Ex-RAD)是一种辐射防护剂，可以激活细胞中AKT和PI3K的活性。

  • GC33135 structure
    GC33135GSK2110183
    CAS: 1047634-63-8

    Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.

  • GC33308 structure
    GC33308AKT-IN-1
    CAS: 1357158-81-6
    纯度: >98.00%

    AKT-IN-1是一种变构AKT抑制剂，IC50为1.042μM。

  • GC33357 structure
    GC33357K-80003 (TX-803)
    CAS: 1292821-90-9
    纯度: >98.00%

    K-80003 (TX-803) 是 tRXRα 的有效抑制剂；依赖 Akt 激活和癌细胞生长。