P450
Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.
P450 相关产品(439)
- GC49559Hydroxymethyl Tolperisone (hydrochloride)CAS: 352233-14-8纯度: >95.00%
A metabolite of tolperisone
- GC49686N-desmethyl Regorafenib N-oxideCAS: 835621-12-0纯度: >90.00%
An active metabolite of regorafenib
- GC49817Desethoxy Quetiapine (hydrochloride)CAS: 329218-14-6纯度: >95.00%
An active metabolite of quetiapine
- GC49855Harmalol (hydrochloride hydrate)CAS: 6028-00-8纯度: >98.00%
A β-carboline alkaloid and an active metabolite of harmaline
- GC49875(±)-N-desmethyl Venlafaxine (hydrochloride)CAS: 93413-90-2纯度: >95.00%
A minor active metabolite of venlafaxine
- GC520627-Benzyloxy-4-(trifluoromethyl)coumarinCAS: 220001-53-6纯度: >95.00%
A fluorogenic substrate for CYP1A2 and CYP3A
- GC5208321-DeoxycortisoneCAS: 1882-82-2纯度: >95.00%
A corticosteroid metabolite of 11-keto progesterone
- GC52132N-desmethyl Diltiazem (hydrochloride)CAS: 130606-60-9纯度: >90.00%
An active metabolite of diltiazem
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC49559 | Hydroxymethyl Tolperisone (hydrochloride) | 352233-14-8 | >95.00% | |
A metabolite of tolperisone | ||||
| GC49583 | N-desmethyl Sertraline (hydrochloride) | 675126-09-7 | >95.00% | |
A metabolite of sertraline | ||||
| GC49627 | Rabeprazole sulfone | 117976-47-3 | >95.00% | |
A metabolite of rabeprazole | ||||
| GC49629 | 6β-hydroxy Prednisolone | 16355-29-6 | >95.00% | |
A metabolite of prednisolone | ||||
| GC49686 | N-desmethyl Regorafenib N-oxide | 835621-12-0 | >90.00% | |
An active metabolite of regorafenib | ||||
| GC49817 | Desethoxy Quetiapine (hydrochloride) | 329218-14-6 | >95.00% | |
An active metabolite of quetiapine | ||||
| GC49832 | Hydroxymetronidazole | 4812-40-2 | >95.00% | |
An active metabolite of metronidazole | ||||
| GC49842 | Digoxigenin Bisdigitoxoside | 5297-05-2 | >98.00% | |
A Na + /K + -ATPase inhibitor | ||||
| GC49851 | Norquetiapine | 5747-48-8 | >98.00% | |
An active metabolite of quetiapine | ||||
| GC49855 | Harmalol (hydrochloride hydrate) | 6028-00-8 | >98.00% | |
A β-carboline alkaloid and an active metabolite of harmaline | ||||
| GC49866 | Desmethyl Carvedilol | 72956-44-6 | >90.00% | |
An active metabolite of carvedilol | ||||
| GC49875 | (±)-N-desmethyl Venlafaxine (hydrochloride) | 93413-90-2 | >95.00% | |
A minor active metabolite of venlafaxine | ||||
| GC50038 | Mephenytoin | 50-12-4 | >99.50% | |
Mephenytoin 是一种抗惊厥药，是 CYP2C19 和 CYP2B6 的底物。 | ||||
| GC52007 | N-hydroxylamine Dapsone | 32695-27-5 | >98.00% | |
An active metabolite of dapsone | ||||
| GC52019 | Norpropranolol (hydrochloride) | 62618-09-1 | >98.00% | |
An active metabolite of propranolol | ||||
| GC52024 | Aripiprazole N-oxide | 573691-09-5 | >90.00% | |
A metabolite of aripiprazole | ||||
| GC52038 | Desthiazolylmethyl Ritonavir | 256328-82-2 | >90.00% | |
A ritonavir degradation product | ||||
| GC52045 | N-desmethyl Azelastine | 47491-38-3 | >98.00% | |
An active metabolite of azelastine | ||||
| GC52060 | Trimipramine N-oxide | 14171-70-1 | >90.00% | |
An active metabolite of trimipramine | ||||
| GC52062 | 7-Benzyloxy-4-(trifluoromethyl)coumarin | 220001-53-6 | >95.00% | |
A fluorogenic substrate for CYP1A2 and CYP3A | ||||
| GC52083 | 21-Deoxycortisone | 1882-82-2 | >95.00% | |
A corticosteroid metabolite of 11-keto progesterone | ||||
| GC52132 | N-desmethyl Diltiazem (hydrochloride) | 130606-60-9 | >90.00% | |
An active metabolite of diltiazem | ||||
| GC60167 | Fipronil | 120068-37-3 | >98.00% | |
An insecticide | ||||
| GC60169 | Friedelin | 559-74-0 | - | |
Friedelin 是从 Maytenus ilicifolia(Mart) 的叶子中分离出来的。 Friedelin 是 CYP3A4 的非竞争性抑制剂，IC50 和 Ki 值分别为 10.79 μM 和 6.16 μM。 Friedelin 还是 CYP2E1 的竞争性抑制剂，IC50 和 Ki 值分别为 22.54 μM 和 18.02 μM。 | ||||