p38
p38 (p38 mitogen-activated protein kinases) are serine/threonine kinases that activated by environmental stress and proinflammatory cydtokines. They mediates cell growth, differentiation, transcrption and development.
p38 相关产品(100)
- GC33238SJFδCAS: 2254609-23-7
SJFδ是一种含10个原子连接桥的PROTAC。SJFδ降解p38α，DC50为46.17nM，但不降解其他p38亚型(p38α,p38β和p38γ)。
- GC351324-HydroxylonchocarpinCAS: 56083-03-5
4-Hydroxylonchocarpin 是一种查尔酮化合物，来自补骨脂 (Psoralea corylifolia) 提取物。4-Hydroxylonchocarpin 增强 p38 MAPK，JNK 和 ERK 的磷酸化。4-Hydroxylonchocarpin 具有多种药理活性，包括抗菌，抗癌，抗逆转录酶，抗结核，抗疟，抗炎和抗氧化活性。
- GC35525BisabolangeloneCAS: 30557-81-4纯度: >98.00%
Bisabolangelone 是从 Osterici Radix 植物的根中分离出来的倍半萜衍生物。Bisabolangelone 具有抗炎作用，通过阻断巨噬细胞内的 NF-kappaB 和 MAPK 通路抑制脂多糖刺激的炎症。Bisabolangelone 具有抗溃疡作用。
- GC35832Dehydrocorydaline chlorideCAS: 10605-03-5纯度: >98.00%
An alkaloid with diverse biological activities
- GC36447Licochalcone ECAS: 864232-34-8纯度: >99.50%
Licochalcone E 是可从Glycyrrhiza inflate 中提取到的黄酮类化合物，通过抑制AKT 和 MAPK 的激活来抑制NF-κB 和 AP-1 的转录活性。
- GC36855Paris saponin VIICAS: 68124-04-9纯度: >98.00% / >98.50%
Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.
- GC38609Rotundic acidCAS: 20137-37-5纯度: >98.00%
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.
- GC39095Isoliquiritin apiosideCAS: 120926-46-7纯度: >99.50%
Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.
- GC39815Semapimod tetrahydrochlorideCAS: 164301-51-3纯度: >98.00%
Semapimod tetrahydrochloride (CNI-1493) 是促炎细胞因子产生 (proinflammatory cytokine) 的抑制剂，可抑制TNF-α、IL-1β 和 IL-6。Semapimod tetrahydrochloride 抑制巨噬细胞 p38 MAPK 和一氧化氮生成。Semapimod tetrahydrochloride 抑制 TLR4 信号 (IC50≈0.3 μM)。Semapimod tetrahydrochloride 在多种炎症和自身免疫性疾病中具有潜在的作用。
- GC41740(S)-p38 MAPK Inhibitor IIICAS: 581098-48-8纯度: >98.00%
A cell-permeable p38 MAP kinase inhibitor
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC33238 | SJFδ | 2254609-23-7 | - | |
SJFδ是一种含10个原子连接桥的PROTAC。SJFδ降解p38α，DC50为46.17nM，但不降解其他p38亚型(p38α,p38β和p38γ)。 | ||||
| GC34072 | Talmapimod (SCIO-469) | 309913-83-5 | >98.00% | |
A p38 MAPK inhibitor | ||||
| GC34918 | MW-150 dihydrochloride dihydrate | 1661020-92-3 | - | |
An inhibitor of p38α MAPK | ||||
| GC35132 | 4-Hydroxylonchocarpin | 56083-03-5 | - | |
4-Hydroxylonchocarpin 是一种查尔酮化合物，来自补骨脂 (Psoralea corylifolia) 提取物。4-Hydroxylonchocarpin 增强 p38 MAPK，JNK 和 ERK 的磷酸化。4-Hydroxylonchocarpin 具有多种药理活性，包括抗菌，抗癌，抗逆转录酶，抗结核，抗疟，抗炎和抗氧化活性。 | ||||
| GC35525 | Bisabolangelone | 30557-81-4 | >98.00% | |
Bisabolangelone 是从 Osterici Radix 植物的根中分离出来的倍半萜衍生物。Bisabolangelone 具有抗炎作用，通过阻断巨噬细胞内的 NF-kappaB 和 MAPK 通路抑制脂多糖刺激的炎症。Bisabolangelone 具有抗溃疡作用。 | ||||
| GC35674 | Chicanine | 78919-28-5 | - | |
Chicanine 是五味子中的木酚素类化合物，可抑制 LPS 诱导的 p38 MAPK，ERK 1/2 和 IκB-α 的磷酸化水平，具有抗炎活性。 | ||||
| GC35832 | Dehydrocorydaline chloride | 10605-03-5 | >98.00% | |
An alkaloid with diverse biological activities | ||||
| GC36447 | Licochalcone E | 864232-34-8 | >99.50% | |
Licochalcone E 是可从Glycyrrhiza inflate 中提取到的黄酮类化合物，通过抑制AKT 和 MAPK 的激活来抑制NF-κB 和 AP-1 的转录活性。 | ||||
| GC36855 | Paris saponin VII | 68124-04-9 | >98.00% / >98.50% | |
Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway. | ||||
| GC37595 | SB 242235 | 193746-75-7 | >98.50% | |
A p38α MAPK inhibitor | ||||
| GC37646 | SKF-86002 | 72873-74-6 | >99.00% | |
An anti-inflammatory agent | ||||
| GC38319 | Dihydrocaffeic acid | 1078-61-1 | >98.00% | |
A polyphenol with diverse biological activities | ||||
| GC38518 | AMG-548 dihydrochloride | 2518299-32-4 | >99.50% | |
An inhibitor of p38α MAPK | ||||
| GC38609 | Rotundic acid | 20137-37-5 | >98.00% | |
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways. | ||||
| GC38708 | Esculin | 531-75-9 | >99.00% | |
A coumarin with antioxidant and anti-inflammatory activities | ||||
| GC38917 | Gossypetin | 489-35-0 | >99.00% | |
A flavonoid with diverse biological activities | ||||
| GC39095 | Isoliquiritin apioside | 120926-46-7 | >99.50% | |
Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity. | ||||
| GC39574 | SR-318 | 2413286-32-3 | >98.50% | |
A dual inhibitor of p38α and p38β MAPKs | ||||
| GC39815 | Semapimod tetrahydrochloride | 164301-51-3 | >98.00% | |
Semapimod tetrahydrochloride (CNI-1493) 是促炎细胞因子产生 (proinflammatory cytokine) 的抑制剂，可抑制TNF-α、IL-1β 和 IL-6。Semapimod tetrahydrochloride 抑制巨噬细胞 p38 MAPK 和一氧化氮生成。Semapimod tetrahydrochloride 抑制 TLR4 信号 (IC50≈0.3 μM)。Semapimod tetrahydrochloride 在多种炎症和自身免疫性疾病中具有潜在的作用。 | ||||
| GC40484 | Ferulic Acid methyl ester | 2309-07-1 | >99.00% | |
A lipophilic antioxidant | ||||
| GC41740 | (S)-p38 MAPK Inhibitor III | 581098-48-8 | >98.00% | |
A cell-permeable p38 MAP kinase inhibitor | ||||
| GC44530 | p38 MAPK Inhibitor | 219138-24-6 | >98.00% | |
A potent inhibitor of p38 MAP kinase | ||||
| GC49241 | Methyl Diethyldithiocarbamate | 686-07-7 | >95.00% | |
An active metabolite of disulfiram | ||||
| GC50316 | Org 48762-0 | 755753-89-0 | - | |
Selective p38α/β inhibitor; orally bioavailable | ||||