GlpBio

Proton Pump

Proton Pump(质子泵)

Proton pump is a protein complex that transport the H+ ion across the membranes of lysosomes and vacuoles to generate an electrical and chemical gradient that provide energy for ATP synthesis from ADP.

Proton Pump 相关产品(55)

  • GC32924 structure
    GC32924Linaprazan (AZD0865)
    CAS: 248919-64-4
    纯度: >98.50%

    An H + /K + -ATPase inhibitor

  • GC33575 structure
    GC33575Esomeprazole potassium salt ((S)-Omeprazole potassium)
    CAS: 161796-84-5

    An H + /K + -ATPase inhibitor

  • GC35982 structure
    GC35982EN6
    CAS: 1808714-73-9
    纯度: >99.00%

    An activator of autophagy

  • GC36009 structure
    GC36009Esomeprazole magnesium salt
    CAS: 1198768-91-0

    An H + /K + -ATPase inhibitor

  • GC36806 structure
    GC36806Omeprazole D3
    CAS: 922731-01-9
    纯度: >98.50%

    An internal standard for the quantification of omeprazole

  • GC36847 structure
    GC36847Pantoprazole sodium
    CAS: 138786-67-1
    纯度: >99.50%

    A proton pump inhibitor

  • GC36848 structure
    GC36848Pantoprazole sodium hydrate
    CAS: 164579-32-2
    纯度: >98.00%

    A proton pump inhibitor

  • GC37756 structure
    GC37756Tenatoprazole sodium
    CAS: 335299-59-7

    A proton pump inhibitor

  • GC37920 structure
    GC37920Vonoprazan
    CAS: 881681-00-1
    纯度: >99.50%

    A selective and reversible proton pump inhibitor

  • GC39429 structure
    GC39429Rabeprazole Sulfide
    CAS: 117977-21-6
    纯度: >98.00%

    An active metabolite of rabeprazole

  • GC39734 structure
    GC39734Diphyllin
    CAS: 22055-22-7
    纯度: >99.50%

    A lignan with diverse biological activities

  • GC47537 structure
    GC47537Lansoprazole-d4
    CAS: 934294-22-1
    纯度: >99.00%

    An internal standard for the quantification of lansoprazole

  • GC60530 structure
    GC605305-Hydroxylansoprazole
    CAS: 131926-98-2
    纯度: >99.50%

    5-Hydroxylansoprazole(AG1908)是血浆中Lansoprazole的活性代谢产物。Lansoprazole由CYP2C19代谢形成5-Hydroxylansoprazole。Lansoprazole是一种胃质子泵(proton-pump)抑制剂，可有效研究各种消化系统疾病。

  • GC60929 structure
    GC60929Ilaprazole sodium
    CAS: 172152-50-0
    纯度: >98.50%

    A gastric proton pump inhibitor

  • GC60975 structure
    GC60975Lansoprazole Sulfide D4
    CAS: 1216682-38-0

    LansoprazoleSulfideD4是LansoprazoleSulfide的氘代物。LansoprazoleSulfide是质子泵抑制剂Lansoprazole的活性代谢产物。LansoprazoleSulfide是一种口服活性抗结核药，细胞内的IC50值为0.59µM，肉汤中的IC50值为0.46µM。

  • GC61155 structure
    GC61155Omeprazole sodium
    CAS: 95510-70-6
    纯度: >98.00%

    An irreversible inhibitor of the gastric proton pump

  • GC61863 structure
    GC61863Verucopeptin
    CAS: 138067-14-8
    纯度: >98.00%

    Verucopeptin 是一种有效的 HIF-1 (IC50=0.22 µM) 抑制剂，可以降低 HIF-1 靶基因的表达和 HIF-1α 的蛋白水平。通过直接靶向 v-ATPase ATP6V1G 亚基 (但不靶向 ATP1V1B2 或 ATP6V1D)，Verucopeptin 强烈抑制 v-ATPase 活性。Verucopeptin 对耐药性癌细胞表现出抗肿瘤活性，常用作癌症相关研究。

  • GC62823 structure
    GC62823Abeprazan
    CAS: 1902954-60-2
    纯度: >99.50%

    Abeprazan (DWP14012) 是一种钾竞争性酸 (potassium-competitive acid) 阻滞剂。Abeprazan 通过可逆的钾竞争性离子结合抑制 H+，K+- ATPase，而无需酸激活。Abeprazan 是一种潜在的质子泵抑制剂，用于研究与酸相关的疾病。

  • GC62885 structure
    GC62885Caloxin 2A1 TFA
    纯度: >99.50%

    Caloxin 2A1 TFA 是一种细胞外质膜 Ca2+-ATPase (PMCA) 肽抑制剂。Caloxin 2A1 TFA 不影响基础 Mg2+-ATPase 或 Na+-K+-ATPase。

  • GC63335 structure
    GC63335Omeprazole-13CD3
    CAS: 1261395-28-1

    Omeprazole-13CD3 (H 16868-13CD3) 是一种 13C 标记和氘代标记 Omeprazole。Omeprazole (H 16868) 是一种质子泵 (proton pump) 抑制剂 (PPI)，有潜力用于胃肠道疾病的研究。Omeprazole 竞争性抑制 CYP2C19 活性，Ki 为 2 到 6 μM。Omeprazole 还抑制革兰氏阳性菌和革兰氏阴性菌生长。Omeprazole 是中性鞘磷脂酶 (N-SMase) 的抑制剂(外泌体抑制剂)。

  • GC63472 structure
    GC63472Zastaprazan
    CAS: 2133852-18-1
    纯度: >99.50%

    Zastaprazan 是一种 proton pump 抑制剂 (WO2018008929)。Zastaprazan 可用于胃肠道炎症或胃酸相关疾病的研究。

  • GC63687 structure
    GC63687Rabeprazole-d4
    CAS: 934295-48-4

    An internal standard for the quantification of rabeprazole

  • GC63954 structure
    GC63954KM91104
    CAS: 304481-60-5
    纯度: >99.00%

    KM 91104 is a cell-permeable inhibitor of V-ATPase that specifically targets the interaction between V-ATPase subunit a3 and subunit B2.

  • GC64070 structure
    GC64070Omeprazole-d3-1
    CAS: 934293-92-2

    An internal standard for the quantification of omeprazole