5-HT Receptor(5-羟色胺受体)

Cat.No. 产品名称 Information

GC31018 NEO 376 (SPI-376)

SPI-376

NEO 376 (SPI-376) 是 5-HT1 受体、GABA 受体和多巴胺受体的选择性调节剂，具有抗精神病活性。

GC32563 Nexopamil racemate

奈索帕米

Nexopamilracemate是Nexopamil的外消旋体。Nexopamil是体内血栓形成和体外血小板聚集中的一种联合Ca2+/5-HT2拮抗剂。

GC63111 NLX-204 hydrochloride NLX-204 is a potent, selective agonist of ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor with pKi of 10.19.

GC11989 Nortriptyline (hydrochloride)

盐酸去甲替林; Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride

A tricyclic antidepressant

GC31015 NRA-0160 NRA-0160是一种选择性的dopamineD4receptor拮抗剂，Ki值为0.48nM；同时对dopamineD2receptor，D3receptor，大鼠5-HT2Areceptor和α1adrenoceptor分别具有不同程度的亲和度，Ki值分别为>10000nM，39nM，180nM和237nM。

GN10607 Nuciferine

荷叶碱

An alkaloid with diverse biological activities

GC31173 Ocaperidone (R79598)

奥卡哌酮,R79598

Ocaperidone (R79598) 是一种有效的抗精神病药，作为有效的 5-HT2 和多巴胺 D2 拮抗剂和 5-HT1A 激动剂，对 5-HT2 的 Kis 分别为 0.14 nM、0.46 nM、0.75 nM、1.6 nM 和 5.4 nM 、a1-肾上腺素受体、多巴胺 D2、组胺 H1 和 a2-肾上腺素受体，h5-HT1A 的 pEC50 和 pKi 分别为 7.60 和 8.08。

GC12495 Olanzapine

奥氮平; LY170053

Olanzapine是一种单胺拮抗剂。

GC61809 Olanzapine D3

奥氮平 D3; LY170053-d3

OlanzapineD3(LY170053D3)是Olanzapine的氘代物。Olanzapine是一种选择性单胺能拮抗剂，高亲和力结合5-羟色胺H1，5HT2A/2C，5HT3，5HT6(Ki分别为7、4、11、57和5nM)，多巴胺D1-4(Ki=11-31nM)，毒蕈碱M1-5(Ki=1.9-25nM)和肾上腺素α1受体(Ki=19nM)。Olanzapine是一种非典型的抗精神病剂。

GC16142 Ondansetron

昂丹司琼; GR 38032; SN 307

A Certified Reference Material

GC11814 Ondansetron HCl

盐酸昂丹司琼; GR 38032 hydrochloride; SN 307 hydrochloride

A Certified Reference Material

GC11651 Ondansetron hydrochloride dihydrate

盐酸昂丹司琼二水物; GR 38032 hydrochloride dihydrate; SN 307 hydrochloride dihydrate

An Analytical Reference Material

GC71604 Ondansetron-d3 hydrochloride Ondansetron-d3 hydrochloride是氘标记的盐酸昂丹司琼。

GC71603 Ondansetron-d5 Ondansetron-d5是氘标记的昂丹司琼。

GC61889 OPC-14523 hydrochloride

OPC-14523盐酸盐

OPC-14523 hydrochloride 是一种具有口服活性的 sigma 和 5-HT1A 受体激动剂，对 sigma 受体 (σ1/2 IC50=47/56 nM)、5-HT1A 受体 (IC50=2.3 nM) 和 5-HT 转运体 (IC50=80 nM) 具有高度亲和力。OPC-14523 hydrochloride 显示抗抑郁药样活性。

GC38828 Org-12962

1-[6-氯-5-(三氟甲基)吡啶-2-基]哌嗪

A 5-HT_2C receptor agonist

GC61401 Oxatomide

欧诗美锭

Oxatomide是一种有效的具有口服活性的双重H1组胺受体(H1-histaminereceptor)和P2X7受体拮抗剂，具有抗组胺和抗过敏活性。Oxatomide几乎完全阻断人P2X7受体中ATP诱导的电流(IC50为0.95μM)。Oxatomide可抑制ATP诱导的Ca2+内流，IC50值为0.43μM，并且还抑制5-羟色胺(serotonin)。

GC60293 p-MPPI hydrochloride p-MPPI hydrochloride 是一种选择性的，具有高亲和力的 5-HT1A 受体拮抗剂。p-MPPI hydrochloride 能穿过血脑屏障，具有明显的抗抑郁和抗焦虑作用。

GC61167 Paliperidone palmitate

棕榈酸帕利哌酮,9-Hydroxyrisperidone palmitate

Paliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class.

GC36844 Palonosetron

帕洛诺司琼

Palonosetron (RS25259, RS 25259 197) is a 5-HT3 antagonist with Ki value of 0.17 nM. It is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).

GC17917 Palonosetron HCl

盐酸帕洛诺司琼

A 5-HT₃ receptor antagonist

GC31022 Pancopride (LAS 30451)

泮考必利,LAS 30451

Pancopride (LAS 30451) 是一种新型的强效选择性 5-HT3 受体拮抗剂。

GC31069 Pardoprunox (SLV-308)

SLV-308; DU-126891

Pardoprunox hydrochloride (DU-126891, SME-308) is a potent but partial dopamine D2 receptor agonist with pEC50 of 8.0, and a partial agonist in the induction of [35S]GTPγS binding with pEC50 of 9.2 and a serotonin 5-HT1A receptor agonist, with pEC50 of 6.3, respectively.

GC30980 Pardoprunox hydrochloride (SLV-308 hydrochloride)

盐酸帕多芦诺,SLV-308 hydrochloride; DU-126891 hydrochloride

A dopamine D₂ and D₃ receptor partial agonist and 5-HT_1A agonist

GC18102 Paroxetine maleate

马来酸帕罗西汀

5-HT uptake inhibitor

GC31767 Peptide 401 Peptide401是一种有效的来源于蜂毒中的肥大细胞脱颗粒肽，抑制血管通透性。

GC39237 Perospirone

哌罗匹隆; SM-9018 free base

Perospirone (SM-9018 free base) is an orally active antagonist of 5-hydroxytryptamine2 (5-HT2) receptor, dopamine2 (D2) receptor and 5-HT1A receptor with Ki of 0.6 nM, 1.4 nM and 2.9 nM, respectively.

GC12293 Perphenazine

奋乃静

A typical antipsychotic

GC36875 Perphenazine D8 Dihydrochloride

奋乃静 D8 二盐酸盐

Perphenazine D8二盐酸盐是Perphenazine氘代化合物标准品。

GC50668 PF 04479745 PF 04479745 是一种有效的选择性 5-HT2C 受体激动剂（EC50:10 nM，ki:15 nM）。 PF 04479745 可用于高血压等心血管疾病的研究。

GC45791 PF-04995274 A partial 5-HT₄ agonist

GC30953 Phenylbiguanide (N-Phenylbiguanide)

1-苯基双胍,N-Phenylbiguanide; PBG; 1-Phenylbiguanide

1-Phenylbiguanide (Phenylbiguanide, PBG, N-Phenylbiguanide) is a 5-hydroxytryptamine3 (5-HT3) receptor agonist with EC50 of 3.0 μM.

GC19294 Piboserod

哌波色罗,SB-207266

A selective, potent 5-HT₄ receptor antagonist

GC36912 Piboserod hydrochloride

SB-207266 hydrochloride

Piboserod (SB 207266)盐酸盐是5-羟色胺受体5-HT4选择性抑制剂。

GC11844 Pimavanserin

匹莫范色林; ACP-103

A 5-HT_2A inverse agonist

GC36919 Pimavanserin tartrate

匹莫范色林L-酒石酸盐,ACP-103 hemitartrate

A 5-HT_2A inverse agonist

GC30999 Pimethixene (Pimetixene)

匹美噻吨,Pimetixene

Pimethixene (Pimetixene) 是抗组胺药和抗血清素能化合物，用作抗偏头痛剂。

GC65296 Pimethixene maleate

匹美噻吨马来酸盐; Pimetixene maleate

Pimethixene (Pimetixene) maleate, an antihistamine, anntimigraine agent and antiserotonergic compound, is a highly potent antagonist of a broad range of monoamine receptors, including a variety of serotonin receptors. Pimethixene maleate inhibits 5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1B, 5-HT6, 5-HT7, Adrenergic α-1A, Dopamine D1 Receptor, Dopamine D2 Receptor, Dopamine D4.4 Receptor, Histamine H1 Receptor, Muscarinic M1 and Muscarinic M2 with pKi of 10.22, 10.44, 8.42, 7.63, < 5, 7.30, 7.28, 7.61, 6.37, 8.19, 7.54, 10.14, 8.61 and 9.38, respectively.

GC17734 Pindolol

吲哚洛尔; LB-46

A β₁- and β₂-AR antagonist

GC36924 Pipamperone

酰胺哌啶酮,Floropipamide; McN-JR 3345; R 3345

Pipamperone (Floropipamide; McN-JR 3345; R 3345) 是 5-HT2A 受体 (pKi=8.2) 和 D4 受体 (pKi=8.0) 的高亲和力拮抗剂。Pipamperone (Floropipamide; McN-JR 3345; R 3345) 是 D2 受体 (pKi=6.7) 的低亲和力拮抗剂。

GC25756 Pirenperone

R-47456, R-50656

Pirenperone (R-47456, R-50656), a quinazoline derivative, is a selective antagonist of SR-2A (5-HT2 serotonin receptor) when employed in low doses. Pirenperone behaves like a typical neuroleptic when used in higher doses (greater than 0.1 mg/kg).