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Home >> Signaling Pathways >> Neuroscience >> 5-HT Receptor

5-HT Receptor(5-羟色胺受体)

5-HT receptor (5-hydroxytryptamine receptors) is a group of GPCRs (G protein-coupled receptors) and LGICs (ligand-gated ion channels) found in the central and peripheral nervous systems.

Products for  5-HT Receptor

  1. Cat.No. 产品名称 Information
  2. GC73217 FFN246 FFN246是血清素转运蛋白（SERT）探针和水疱单胺转运蛋白2 （VMAT2）的荧光双底物，激发和发射光谱为392/427 nm。
  3. GC31011 FK1052 hydrochloride

    (±)-FK1052

     FK1052 hydrochloride ((±)-FK1052) 是 Fabesetron hydrochloride 的消旋体，是一种有效的 5-HT3 和 5-HT4 受体双重拮抗剂。
  4. GC60846 Flesinoxan

    氟辛克生

     Flesinoxan是一种降压剂，是一种有效的，高亲和力的选择性的5-羟色胺1A(5-HT1A)受体激动剂，EC50值为24nM。Flesinoxan还具有有效的抗焦虑/抗抑郁作用。
  5. GC11100 Flibanserin

    氟立班丝氨; BIMT-17; BIMT-17BS

     A 5-HT1A receptor agonist and 5-HT2A receptor antagonist
  6. GC74179 Flibanserin hydrochloride (propan-2-ol) hydrate

    盐酸氟立班丝氨; BIMT-17 hydrochloride (propan-2-ol) hydrate; BIMT-17BS hydrochloride (propan-2-ol) hydrate

     Flibanserin hydrochloride (propan-2-ol) hydrateKi值分别为1nM和49nM的口服活性血清素5-HT1A受体激动剂和5-HT2A受体拮抗剂。
  7. GC68364 Flibanserin-d4-1

    BIMT-17-d4-1; BIMT-17BS-d4-1

     Flibanserin-d4-1 是 Flibanserin 氘代物。Flibanserin (BIMT-17) 是 5-羟色胺 (5-HT1A) 受体 (Ki=1 nM) 的完全激动剂和 5-HT2A 拮抗剂 (49 nM)。Flibanserin 与多巴胺 D4 受体 (Ki=4-24 nM) 结合，对多种其他神经递质受体和离子通道的亲和力可忽略不计。Flibanserin 有潜力用于性欲减退 (HSDD)的研究。
  8. GC12535 Flopropione

    夫洛丙酮

     Flopropione 是一种 5-HT 受体拮抗剂，也是一种儿茶酚-邻甲基转移酶 (COMT) 抑制剂。
  9. GC38912 Flumexadol

    氟甲沙朵

     Flumexadol 是一种口服活性非麻醉镇痛药。Flumexadol 是一种选择性和亲和力的 5-HT2C 受体激动剂，对于 Flumexadol 的 (+)-对映体，Ki 为 25 nM，选择性是 5-HT2A 受体的 40 倍。
  10. GC11709 Fluoxetine HCl

    盐酸氟西汀; LY 110140

     An Analytical Reference Material
  11. GC13092 Fluvoxamine

    氟伏沙明; DU-23000

     A selective serotonin reuptake inhibitor
  12. GC15025 Fluvoxamine maleate

    氟伏沙明马来酸盐; DU-23000 maleate

     A selective serotonin reuptake inhibitor
  13. GC73914 FPT FPT2-氨基四氢萘是5-HT1AR的有效部分激动剂，5-HT1BR和5-HT1DR的完全激动剂，EC50s分别为39.3 nM、1.2 nM、0.5 nM。
  14. GC25434 Frovatriptan Succinate

    SB 209509 Succinate,VML 251 Succinate

     Frovatriptan Succinate(SB 209509 Succinate,VML 251 Succinate) is the succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity especially for the 5-HT1B/1D receptors.
  15. GC38781 Frovatriptan succinate hydrate

    罗曲普坦琥珀酸盐,(R)-Frovatriptan succinate hydrate; SB 209509 succinate hydrate; VML 251 succinate hydrate

     An agonist of 5-HT1B and 5-HT1D receptors
  16. GC38227 Gamma-Mangostin

    γ-倒捻子素,γ-Mangostin

     A xanthone with diverse biological activities
  17. GC38529 Geissoschizine methyl ether

    缝籽木嗪甲醚

     Geissoschizine methyl ether，一种 Uncaria hook 发现的生物碱类化合物，也是具有精神药物作用的 Yokukansan 的主要活性成分。Geissoschizine methyl ether 是有效的 5-HT1A 受体的激动剂。
  18. GC70532 Gepirone-d8 Gepirone-d8是氘标记的吉皮隆。
  19. GC11624 GR 113808 GR 113808是一种有效和选择性的5-HT4受体拮抗剂，pKb=8.8。
  20. GC61464 GR 125743 GR125743是一种选择性的5-HT1B/1D受体拮抗剂，与野生型的人h5-HT1B和5-HT1D结合的pKi分别为8.85和8.31。GR125743可用于帕金森病和心血管疾病的研究。
  21. GC74636 GR 55562 hydrochloride GR 55562 hydrochloride是一种选择性5-HT1B受体拮抗剂。
  22. GC12398 Granisetron

    格拉司琼; BRL 43694

     Granisetron (BRL 43694) 是一种血清素 5-HT3 受体拮抗剂，用作止吐剂，用于治疗化疗后的恶心和呕吐。
  23. GC16029 Granisetron HCl

    盐酸格拉司琼; BRL 43694A

     A 5-HT3 receptor antagonist with antiemetic activity
  24. GC19176 GSK163090 GSK163090 是一种有效的、选择性的和具有口服活性的 5-HT1A/1B/1D 受体拮抗剂，pKi 值分别为 9.4/8.5/9.7。
  25. GC30762 Harmine (Telepathine)

    去氢骆驼蓬碱; Telepathine

     A unique regulator of PPARγ expression
  26. GC38413 Harmine hydrochloride

    哈尔碱盐酸盐(水合),Telepathine hydrochloride

     A unique regulator of PPARγ expression
  27. GC60915 Hydroxy ziprasidone

    齐拉西酮羟基化杂质

     Hydroxyziprasidone是Ziprasidone的杂质。Ziprasidone，一种抗精神药物，是5-HT和多巴胺(dopaminereceptor)受体拮抗剂。
  28. GC36291 Idalopirdine

    Lu AE58054

     A 5-HT6 receptor antagonist
  29. GC63015 Iferanserin

    S-MPEC

     Iferanserin (S-MPEC) 是一种对 5-HT2A 受体具有亲和力的选择性 5-HT 受体拮抗剂。Iferanserin 可用于内痔疾病的研究。
  30. GC15463 Iloperidone

    伊潘立酮; HP 873

     An atypical antipsychotic
  31. GC10799 Iloperidone hydrochloride

    盐酸伊潘立酮; HP 873 hydrochloride

     An atypical antipsychotic
  32. GC12885 Imipramine (hydrochloride)

    盐酸丙咪嗪

     A tricyclic antidepressant
  33. GC14093 Indatraline hydrochloride

    茚达曲林盐酸盐; Lu 19-005

     Indatraline hydrochloride (Lu 19-005) 是一种非选择性单胺转运蛋白抑制剂，可阻断神经递质（多巴胺、血清素和去甲肾上腺素）的再摄取，其功效与可卡因相似。
  34. GC61565 Indophagolin

    5-溴-N-(4-氯-3-(三氟甲基)苯基)-1-(环丙烷羰基)吲哚啉-6-磺酰胺

     Indophagolin, a potent indoline-containing autophagy inhibitor with IC50 of 140 nM, antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively, also has a strong antagonistic effect on serotonin receptor 5-HT6 with IC50 of 1.0 μM.
  35. GC60938 Iprindole

    伊普吲哚

     Iprindole具有抗抑郁的生物活性，是一种弱的去甲肾上腺素和5-HT摄取的抑制剂。
  36. GC13133 Ipsapirone

    依普西隆,TVX Q 7821 free base

     A partial agonist of serotonin 5-HT1A receptors
  37. GC31014 Irindalone (Lu 21-098)

    茚达酮,Lu 21-?098

     Irindalone (Lu 21-098) 是一种新型血清素 5-HT2 拮抗剂。
  38. GC11984 Isamoltane hemifumarate Isamoltane hemifumarate 是 5-HT1B 受体的选择性拮抗剂，抑制 [125I]ICYP 与大鼠脑膜中 5-HT1B 识别位点的结合，IC50 为 39 nM。
  39. GN10186 Isocorynoxeine

    异去氢钩藤碱; 7-Isocorynoxeine

     An alkaloid with diverse biological activities
  40. GC39076 Isopteropodine

    钩藤碱 E

     Isopteropodine 是从 Uncaria tomentosa 分离得到的一种异育亨宾型辛吲哚生物碱，是 M1 型毒蕈碱乙酰胆碱 (muscarinic M1) 受体及 5-HT2 受体的正向调节剂。
  41. GC38433 Jatrorrhizine

    药根碱

     An alkaloid with diverse biological activities
  42. GC43926 Jatrorrhizine (chloride)

    盐酸药根碱

     An alkaloid with diverse biological activities
  43. GC60957 Jatrorrhizine hydroxide Jatrorrhizine (Neprotin, Yatrorizine), one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.
  44. GC31251 JNJ-18038683 JNJ-18038683是5-羟色胺受体7(5-HT7)的拮抗剂，HEK293细胞中检测出其对大鼠和人类5-羟色胺受体7的pKi值分别为8.19，8.20。
  45. GC14563 Ketanserin

    酮色林; R41468

     A potent 5-HT2 receptor antagonist
  46. GC43999 Ketanserin (tartrate)

    酒石酸酮色林,R41468 tartrate

     A potent 5-HT2 receptor antagonist
  47. GC72920 Ketanserinol

    R 46742

     Ketanserinol (R 46742)是酮色胺的代谢物。
  48. GC60965 Keto Ziprasidone KetoZiprasidone是Ziprasidone的杂质。Ziprasidone，一种抗精神药物，是5-HT和多巴胺(dopaminereceptor)受体拮抗剂。
  49. GC15121 Lasmiditan

    拉米地坦

     An Analytical Reference Standard
  50. GC36428 Lasmiditan hydrochloride An Analytical Reference Standard
  51. GC25563 Lasmiditan succinate

    COL-144, LY573144

     Lasmiditan succinate (COL-144, LY573144) is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (Ki=2.21 nM) without vasoconstrictor activity.

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