Other Apoptosis(其他细胞凋亡)

Cat.No. 产品名称 Information

GC19199 Importazole

IPZ

Importazole是一种小分子抑制剂，能够抑制转运受体Importin-β的功能，可用于评估细胞周期特定阶段Importin-β/RanGTP通路的功能。

GC19200 INCB-057643 A BET family protein inhibitor

GC17866 INCB28060

卡马替尼; INC280; INCB28060

An inhibitor of HGFR (c-Met)

GC38213 Incensole Acetate

因香酚乙酸酯

A diterpene with diverse biological activities

GC36308 Indibulin

2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺,ZIO 301; D 24851

An inhibitor of microtubule assembly

GC12975 Indirubin

靛玉红; Couroupitine B; Indigo red; Indigopurpurin

Indirubin是强效的周期蛋白依赖性激酶（CDKs）（IC₅₀：50-100nmol/L）和糖原合成酶激酶-3β（GSK-3β）（IC₅₀：5-50nmol/L）抑制剂，具有口服给药特性。

GC10334 INH6

N-[4-(2,4,6-三甲基苯基)-2-噻唑基]苯甲酰胺

A Hec1/Nek2 inhibitor

GC15148 Ionomycin calcium salt

罗红霉素钙盐(链霉菌属载体),SQ23377 calcium

Ionomycin calcium salt是一种窄谱抗生素,对革兰氏阳性菌具有活性,由丛生链霉菌(Streptomyces conglobatus)产生。

GC15446 Ionomycin free acid

离子霉素,SQ23377

Ionomycin free acid 是一种选择性的强效钙离子载体，可作为活性 Ca2+ 载体。

GC46027 IP7e

Isoxazolo-pyridinone 7e

An activator of Nurr1 signaling

GC10467 Irbesartan

厄贝沙坦; SR-47436; BMS-186295

An AT₁ receptor antagonist

GC12962 Isatin

靛红,Indoline-2,3-dione

Isatin (Indoline-2,3-dione) 是一种有效的单胺氧化酶 (MAO) 抑制剂，IC50 为 3 μM。

GN10666 Isoalantolactone

异土木香内酯; (+)-Isoalantolactone; Isohelenin

A sesquiterpene lactone with diverse biological activities

GC13795 Isobavachalcone

补骨脂乙素; Corylifolinin; Isobacachalcone

A chalcone and flavonoid with diverse biological activities

GC38220 Isoliensinine

异莲心碱

Isoliensinine 是从 Nelumbo nucifera 种子胚中提取的双苄基异喹啉生物碱，具有一种具有抗氧化、抗炎、抗癌活性活性。Isoliensinine 能诱导三阴性乳腺癌细胞凋亡。

GN10088 Isoliquiritigenin

异甘草素; GU17; ISL; Isoliquiritigen; SJ000286237

A flavonoid with diverse biological activities

GC36343 Isosilybin A

异水飞蓟宾A

Isosilybin A 是一种从 silymarin 中分离出来的黄酮木脂素，具有抗前列腺癌 (PCA) 活性。Isosilybin A 抑制癌细胞增殖并诱导 G1 期停滞和凋亡，通过靶向 Akt-NF-κB-androgen receptor (AR) 轴激活前列腺癌细胞的凋亡机制。

GC36344 Isosilybin B

异水飞蓟宾B

Isosilybin B，一种从 silymarin 中分离的黄酮木脂素，具有抗前列腺癌 (PCA) 活性，抑制癌细胞增殖，诱导 G1 期阻滞和凋亡。Isosilybin B 引起雄激素受体降解。

GC13394 Ispinesib (SB-715992)

伊斯平斯; SB-715992

An Eg5 inhibitor

GC15462 ISRIB (trans-isomer)

ISRIB(TRANS-ISOMER)抑制剂

ISRIB (trans-isomer)是一种选择性抑制整合应激反应（ISR）通路的小分子化合物。ISRIB (trans-isomer)是PERK的一种高度选择性抑制剂，IC₅₀为5nM。

GC16869 Ixabepilone

伊沙匹隆; BMS-247550; Aza-epothilone B

A broad-spectrum anticancer agent

GN10645 Jaceosidin

棕矢车菊素

A natural methylated trihydroxyflavone

GC34634 JG-98

3-苄基-2-((Z)-((E)-5-(6-氯-3-甲基苯并[D]噻唑-2(3H)-亚基)-3-乙基-4-氧代噻唑啉-2-亚基)甲基)噻唑-3-鎓氯化物

JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.

GC15603 JIB-04

5-氯-2(1H)-吡啶酮(2E)-(苯基-2-吡啶基亚甲基)腙

A pan Jumonji histone demethylase inhibitor

GC12117 JNJ-26854165 (Serdemetan)

N-[2-(1H-吲哚-3-基)乙基]-N'-(4-吡啶基)-1,4-苯二胺,JNJ 26854165

An antagonist of MDM2 action

GC12612 JNJ-7706621

JNJ7706621, JNJ 7706621

A dual inhibitor of CDKs and Aurora kinases

GC16167 K 858 An inhibitor of Eg5

GC15281 K-252c

孢菌素甙元,Staurosporinone

A cell-permeable PKC inhibitor

GC12247 K-Ras(G12C) inhibitor 12 An allosteric inhibitor of oncogenic K-Ras(G12C)

GC38209 Kahweol

咖啡豆醇

A natural diterpene with anti-inflammatory and antiangiogenic properties

GC13339 Ketoprofen

酮洛芬; RP-19583

A non-selective COX inhibitor

GC36393 Kinetin riboside

激动素核苷; N6-Furfuryladenosine

An anticancer nucleoside

GC16922 Kobe0065 A selective Ras inhibitor

GC19215 KRIBB11 An Hsf1 inhibitor

GC17346 KT 5823

蛋白激酶仰制剂KT5823

Potent selective inhibitor of cGMP-dependent protein kinase (PKG)

GC14592 KW 2449

[4-[2-(1H-吲唑-3-基)乙烯基]苯基]-1-哌嗪基甲酮

A multi-kinase inhibitor

GC15364 L-685,458

L-685,458

A γ-secretase inhibitor

GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate)

谷氨酸单钠盐

L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

GC30266 L-SelenoMethionine

L-硒代蛋氨酸

A naturally occurring amino acid with antioxidant properties

GN10456 L-Theanine

L-茶氨酸; L-Glutamic Acid γ-ethyl amide; Nγ-Ethyl-L-glutamine

A neuroprotective amino acid

GC15550 Lacidipine

拉西地平

An L-type calcium channel blocker

GC10474 Laquinimod (ABR-215062)

拉喹莫德; ABR-215062

An immunomodulator

GC36424 Larotaxel

XRP9881

Larotaxel (XRP9881) 是一种紫杉烷类似物，具有抗紫杉烷抗性乳腺癌的临床前活性。Larotaxel (XRP9881) 通过促进微管蛋白装配和稳定微管发挥其细胞毒性作用，并最终通过细胞凋亡导致细胞死亡。Larotaxel (XRP9881) 具有穿越血脑屏障的能力，对 P-糖蛋白 1 的亲和力比 Docetaxel 低得多。

GC11784 LCZ696

沙库必曲/缬沙坦; LCZ696

A dual angiotensin II receptor antagonist and neprilysin inhibitor

GC17067 LDC000067

(3-(6-(2-甲氧基苯基)嘧啶-4-基氨基)苯基)甲烷磺酰胺,LDC067

A Cdk9 inhibitor

GC10510 LDN 57444

Ubiquitin C-terminal Hydrolase L1 Inhibitor, UCHL1 Inhibitor

An inhibitor of UCH-L1

GC36434 Leachianone A

里查酮A

Leachianone A 从槐花中分离，具有抗疟疾，抗炎和细胞毒性作用。Leachianone A 诱导细胞凋亡 (apoptosis)。

GC14976 Lenalidomide (CC-5013)

来那度胺; CC-5013

An analog of thalidomide

GC36456 Licoricidin

甘草西定

Licoricidin (LCD) 从甘草 Glycyrrhiza uralensis Fisch 中分离，具有抗癌活性。Licoricidin (LCD) 通过诱导周期停滞，诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)，是一种对抗结直肠癌的潜在化学预防或化学治疗剂。Licoricidin (LCD) 通过抑制肿瘤血管生成和淋巴管生成以及肿瘤组织局部微环境的变化抑制肺转移。Licoricidin (LCD) 通过体外和体内 Akt 和 NF-κB 途径的失活，增强吉西他滨诱导的骨肉瘤 (OS) 细胞的细胞毒性。Licoricidin (LCD) 通过 ROS 清除阻断 UVA 诱导的光老化，限制 MMP-1 的活性，被认为是新的局部应用的抗衰老制剂中的活性成分。

GC33831 Lidocaine hydrochloride (Lignocaine hydrochloride)

盐酸利多卡因; Lignocaine hydrochloride

An Analytical Reference Standard