Other Apoptosis(其他细胞凋亡)

Cat.No. 产品名称 Information

GC17255 Gliotoxin

胶霉毒素,Aspergillin

Gliotoxin是一种由病原性曲霉菌等真菌产生的免疫抑制性霉菌毒素，是一种特异性的20S蛋白酶体糜蛋白酶活性抑制剂，IC₅₀为10μM。

GC36151 Glucagon-Like Peptide (GLP) II, human

[ALA19]-GLUCAGON-LIKE肽II(大鼠)

Glucagon-Like Peptide (GLP) II, human 是由原胰高血糖素 C 端衍生的33 氨基酸肽，主要由肠道L细胞产生。Glucagon-Like Peptide (GLP) II 可刺激肠粘膜生长，减少肠细胞的凋亡。

GN10321 Glycitein

黄豆黄素; Glycetein

A major isoflavone

GC34092 Glycochenodeoxycholic acid (Chenodeoxycholylglycine)

甘氨鹅脱氧胆酸; Chenodeoxycholylglycine

A quantitative analytical standard guaranteed to meet MaxSpec^? identity, purity, stability, and concentration specifications

GC43776 Glycochenodeoxycholic Acid (sodium salt)

甘氨鹅脱氧胆酸钠; Chenodeoxycholylglycine sodium salt; Sodium glycochenodeoxycholate

A primary bile acid

GC36167 GMB-475 GMB-475 is a proteolysis-targeting chimera (PROTAC) that allosterically targets BCR-ABL1 protein and recruit the E3 ligase Von Hippel-Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein.

GC14815 GMX1778 (CHS828)

N-[6-(4-氯苯氧基)己基]-N'-氰基-N''-4-吡啶基胍,GMX1778

A pyridyl cyanoguanidine anti-tumor agent

GC36179 Gomisin N

戈米辛N

Gomisin N 是从Schisandra chinensis 中分离得到的，具有良好的镇静催眠作用。Gomisin N 有治疗过敏的潜力。Gomisin N 还是一种具有通过诱导癌细胞凋亡从而发挥抗肿瘤增值作用的候选药物。

GC15865 GRI 977143

An LPA₂ receptor agonist

GC13484 Griseofulvin

灰黄霉素

A fungal metabolite with antifungal and anticancer activities

GC12555 GS-9620

维沙莫德; GS-9620

A TLR7 agonist

GC14987 GSK-3 Inhibitor IX (BIO)

(2'Z,3'E)-6-溴靛玉红-3'-肟,GSK-3 Inhibitor IX

A potent, selective, and reversible GSK3 inhibitor

GC15659 GSK-923295

3-氯-N-{(1S)-2-[(N,N-二甲基甘氨酰)氨基]-1-[(4-{8-[(1S)-1-羟基乙基]咪唑并[1,2-A]吡啶-2-基}苯基)甲基]乙基}-4-[(1-甲基乙基)氧基]苯甲酰胺,GSK 923295;GSK923295

An inhibitor of CENP-E

GC11018 GSK1059615

(5Z)-5-[[4-(4-吡啶基)-6-喹啉基]亚甲基]-2,4-噻唑烷二酮

A potent PI3K inhibitor

GC10008 GSK1070916

GSK-1070916A

A potent inhibitor of Aurora B and C kinases

GC14063 GSK1324726A

I-BET726

A selective inhibitor of BET family proteins

GC19179 GSK2256098 A FAK inhibitor

GC17450 GSK2606414

GSK 2606414;GSK-2606414

GSK2606414是一种具有口服活性的选择性蛋白激酶R样内质网激酶（PERK）抑制剂，IC₅₀值为0.4nM。

GC11068 GSK2656157 A PERK inhibitor

GC32681 GSK2795039 A NOX2 inhibitor

GC17658 Guggulsterone

香胶甾酮; Z/E-Guggulsterone

Guggulsterone 是一种植物甾醇，来自于 Commiphora wightii 的树胶树脂。 Guggulsterone 通过下调抗凋亡基因产物（IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP 和 survivin），调节细胞周期蛋白（cyclin D1 和c-Myc)，激活半胱天冬酶和 JNK，抑制 Akt。 Guggulsterone 是一种法尼醇 X 受体 (FXR) 拮抗剂，可降低 CDCA 诱导的 FXR 活化，对 Z- 和 E-Guggulsterone 的 IC50 分别为 17 和 15 μM。

GC14123 GW441756 A potent inhibitor of TrkA

GC11685 GW5074 A potent inhibitor of Raf-1

GC38088 Hederacolchiside A1

革叶常春藤皂苷 A1

Hederacolchiside A1 是从白头翁中分离的，通过调节 PI3K/Akt/mTOR 信号通路诱导凋亡，从而抑制肿瘤细胞的增殖。Hederacolchiside A1 具有抗血吸虫病活性，影响体内和体外的寄生虫生存力。

GN10248 Hesperitin

橙皮素

A hypocholesterolemic citrus flavonoid

GC15178 Hexamethonium Bromide

六甲溴铵

A nondepolarizing neuromuscular blocking agent

GC38099 Higenamine

去甲乌药碱; Norcoclaurine

Demethyl-Coclaurine (Higenamine, Norcoclaurine), the key component of the Chinese herb aconite root, is a beta-2 adrenergic receptor (β2-AR) agonist. Demethyl-Coclaurine stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes.

GC38237 Higenamine hydrochloride

盐酸去甲乌头碱,Norcoclaurine hydrochloride

Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.

GC36229 Hirsutine

毛钩藤碱

Hirsutine，一种 Uncaria rhynchophylla 的吲哚生物碱，具有抗癌活性。Hirsutine 诱导细胞凋亡，并且是一种有效的 Dengue virus 抑制剂，具有低毒性。

GC32807 HJC0152 hydrochloride

2-(2-氨基乙氧基)-5-氯-N-(2-氯-4-硝基苯基)苯甲酰胺盐酸盐

An orally bioavailable inhibitor of STAT3

GC17023 HLCL-61 A PRMT5 inhibitor

GC16208 HO-3867 A selective STAT3 inhibitor

GC11574 HPOB A potent and selective inhibitor of HDAC6

GC16713 HS-173 A PI3K inhibitor

GC11973 HSP990 (NVP-HSP990)

HSP-990

An Hsp90 inhibitor

GC36270 Hydrolyzed Fumonisin B1

Aminopentol

Hydrolyzed Fumonisin B1 (Aminopentol) 是真菌毒素 fumonisin B1 (FB1) 的主要水解产物，具有较弱的抑制神经酰胺合成酶的作用。

GC16843 Hydroxyurea

羟基脲; Hydroxycarbamide

An antineoplastic agent

GN10302 Hypericin

金丝桃素

An anthroquinone derivative

GC36283 Hypocrellin B

竹红菌乙素

A fungal metabolite

GC19194 IACS-10759

5-(5-甲基-1-(3-(4-(甲基磺酰基)哌啶-1-基)苄基)-1H-1,2,4-三唑-3-基)-3-(4-(三氟甲氧基)苯基)-1,2,4-恶二唑,IACS-10759

IACS-10759 (IACS-010759) 是一种氧化磷酸化抑制剂，IACS-10759 是一种有效的氧化磷酸化复合物 I ( OXPHOS ) 抑制剂。

GC36286 IACS-10759 Hydrochloride

IACS-10759 hydrochloride

IACS-10759 Hydrochloride 是一种具有口服活性的强效线粒体复合物 I 的氧化磷酸化 (OXPHOS) 抑制剂。 IACS-10759 Hydrochloride 在依赖 OXPHOS 的脑癌和急性髓性白血病 (AML) 模型中抑制增殖并诱导细胞凋亡。 IACS-10759 Hydrochloride 具有用于复发/难治性 AML 和实体瘤研究的潜力。