Other Apoptosis(其他细胞凋亡)

Cat.No. 产品名称 Information

GC16589 Limonin

柠檬苦素; Limonoic acid 3,19

柠檬苦素是一种天然的四环三萜类化合物，广泛存在于桉树、黄柏和黄连中。

GN10122 Linalool

芳樟醇

A monoterpene alcohol with diverse biological activities

GC38086 Linderalactone

异乌药内酯

Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins (Bax and Bcl-2) with an IC50 of 15 ?M in A-549 cells. Linderalactone induces G2/M cell cycle arrest and could also suppress the JAK/STAT signalling pathway. Linderalactone can be isolated from Radix linderae.

GC17958 Linifanib (ABT-869)

利尼伐尼,ABT-869; AL-39324

A dual VEGFR and PDGFR family kinase inhibitor

GC17057 Lithocholic Acid

石胆酸; 3α-Hydroxy-5β-cholanic acid

A toxic secondary bile acid

GC16039 LJH685

2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚

An inhibitor of RSKs

GN10405 Loganin

马钱子苷; Loganoside

An iridoid glycoside with diverse biological activities

GC18404 Lometrexol

洛美曲索,DDATHF

A GART inhibitor

GC17865 Lomustine

洛莫司汀; CCNU; NSC 79037

A DNA alkylating agent

GC11532 Lonidamine

氯尼达明; AF-1890; Diclondazolic Acid; DICA

Lonidamine是一种己糖激酶、线粒体丙酮酸载体（在分离的大鼠肝脏线粒体中Ki为2.5μM）和质膜单羧酸转运蛋白抑制剂，同时还抑制线粒体复合物 II。

GC15282 LOXO-101 (Larotrectinib) sulfate

(3S)-N-[5-[(2R)-2-(2,5-二氟苯基)-1-吡咯烷基]吡唑并[1,5-A]嘧啶-3-基]-3-羟基-1-吡咯烷甲酰胺硫酸盐,LOXO-101 sulfate; ARRY-470 sulfate

A pan-Trk inhibitor

GC10809 LRRK2-IN-1

5,11-二氢-2-[[2-甲氧基-4-[[4-(4-甲基-1-哌嗪基)-1-哌啶基]羰基]苯基]氨基]-5,11-二甲基-6H-嘧啶并[4,5-B][1,4]苯并二氮杂卓-6-酮,LRRK 2-IN-1

A selective LRRK2 inhibitor

GC36488 Lucidenic acid B

赤芝酸 B

Lucidenic acid B 是从灵芝中分离得到的天然产物，可诱导肿瘤细胞凋亡，可产生 caspase-9 和 caspase-3 的活化和 PARP 的裂解。Lucidenic acid B 对细胞周期没有影响，且对坏死细胞无作用。

GN10142 Lupeol

羽扇豆醇; Clerodol; Monogynol B; Fagarasterol

A dietary triterpene with anti-inflammatory and anticancer activity

GN10370 Luteolin

木犀草素; Luteoline; Luteolol; Digitoflavone

木犀草素（Luteolin）是一种黄酮类化合物，具有抗炎、抗氧化、抗癌等多种功能。Luteolin是一种有效的核因子红细胞2相关因子2（Nrf2）抑制剂。

GC32724 LW6 (HIF-1α inhibitor)

HIF-1α inhibitor; LW8

LW6是一种缺氧诱导因子1(hypoxia inducing factor 1, HIF)抑制剂,通过降解HIF-1α有效抑制HIF-1α的积累,但不影响缺氧时HIF- 1a mRNA水平。

GC15485 LY 294002

LY294002/PI3K抑制剂

LY294002是第一个合成的PI3Kα、δ和β抑制剂。

GC12191 LY-411575

(AS)-N-[(1S)-2-[[(7S)-6,7-二氢-5-甲基-6-氧代-5H-二苯并[B,D]氮杂卓-7-基]氨基]-1-甲基-2-氧代乙基]-3,5-二氟-ALPHA-羟基苯乙酰胺

A γ-secretase inhibitor

GC16835 LY2228820

5-[2-(叔丁基)-4-(4-氟苯基)-1H-咪唑-5-基]-3-(2,2-二甲基丙基)-3H-咪唑并[4,5-B]吡啶-2-胺甲磺酸盐,LY2228820 dimesylate

A potent inhibitor of p38α MAP kinase

GC10093 LY2409881

IKK2抑制剂（LY2409881）

A selective IKK2 inhibitor

GC11971 LY2857785 A Cdk9 inhibitor

GC36516 Lycopodine

石松鹼

Lycopodine，一种石松 (Lycopodium clavatumspores) 孢子重要的生物活性成分，通过调节难治性前列腺癌细胞中 5-脂氧合酶 (5-lipoxygenase)，极化线粒体膜电位而不调节 p53 活性来诱导细胞凋亡。 Lycopodine 通过激活 caspase-3 诱导细胞凋亡来抑制 HeLa 细胞的增殖。

GC17785 Macitentan

马西替坦; ACT-064992

A dual ET_A/ET_B receptor antagonist

GC45723 Macitentan-d4

马其顿D4,ACT-064992-d4

An internal standard for the quantification of macitentan

GN10173 Madecassoside

羟基积雪草苷; Asiaticoside A

A triterpenoid with anti-inflammatory, wound healing, and antioxidant activities

GN10491 Mangiferin

芒果苷

A xanthone glucoside with diverse biological activities

GC10265 Manumycin A

手霉素A

A farnesyltransferase inhibitor with antitumor activity

GC36542 MARK4 inhibitor 1 MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM for MARK4 inhibition assay.

GC13410 Masitinib (AB1010)

马赛替尼; AB1010

An inhibitor of c-Kit

GC36546 Masitinib mesylate

甲磺酸马赛替尼; AB-1010 mesylate

An inhibitor of c-Kit

GC32895 Maytansinol (Ansamitocin P-0)

美登醇,Ansamitocin P-0

An ansa macrolide

GC36552 MBM-17 MBM-17 (compound 42c) 是有效的 NIMA-related kinase 2 (Nek2) 抑制剂，IC50 值为 3 nM，通过诱导细胞周期停滞和凋亡，抑制癌细胞的增殖，具有抗肿瘤活性，且对小鼠没有明显的毒性。

GC36553 MBM-55 MBM-55 (compound 42g) 是有效的 NIMA-related kinase 2 (Nek2) 抑制剂，IC50 值为 1 nM，是其他激酶选择性的 20 倍甚至更高，除了 RSK1 (IC50=5.4 nM) 和 DYRK1a (IC50=6.5 nM)。MBM-55 通过诱导细胞周期停滞和凋亡抑制癌细胞的增殖。具有抗肿瘤活性，且对小鼠没有明显的毒性。

GC10200 Mdivi 1

3-(2,4-二氯-5-甲氧基苯基)-2,3-二氢-2-硫代-4(1H)-喹唑啉酮,Mitochondrial division inhibitor 1

Mdivi-1（线粒体分裂抑制剂 1）抑制创伤性脑损伤 (TBI) 诱导的动力蛋白相关蛋白 1 (Drp1) 上调、自噬功能障碍和线粒体自噬激活。

GC17649 Mebendazole

甲苯咪唑

A broad-spectrum anthelmintic that inhibits microtubules

GC14312 Meisoindigo

甲异靛; Dian III; N-Methylisoindigotin; Natura-α

An anticancer agent

GC11762 Meloxicam (Mobic)

美洛昔康

A selective COX-2 inhibitor

GC12393 Melphalan

Alanine Nitrogen Mustard, Alkeran, NSC 8806, NSC 241286, L-Phenylalanine Mustard

DNA alkylating agent

GC10405 Methotrexate

甲氨蝶呤; Amethopterin; CL14377; WR19039

甲氨蝶呤（Methotrexate）是一种抗叶酸类抗代谢药，有效抑制二氢叶酸还原酶（DHFR）活性，IC50约为7nM。

GC31783 Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester)

3,4-二羟基苯甲酸甲酯,Protocatechuic acid methyl ester; Methyl protocatechuate

Methyl protocatechuate (Methyl 3,4-dihydroxybenzoate, 3,4-Dihydroxybenzoic acid methyl ester, Protocatechuic Acid Methyl Ester) is also known as Protocatechuic Acid Methyl Ester. Protocatechuic Acid, a dihydroxybenzoic acid, is a major metabolite of antioxidant polyphenols found in green tea with antioxidant and anti-inflammatory effects.