Other Apoptosis

(E)-[6]-Dehydroparadol来自专利US9272994化合物M15,能够抑制人体癌细胞生长并且诱导细胞凋亡。在HCT-116和H-1299细胞中的IC50值分别为43.02和41.59μM。

Desacetylcinbufotalin (Deacetylcinbufotalin) 是一种天然化合物；凋亡诱导剂，对HepG2细胞有明显抑制作用，IC50值为0.0279μ；mol/ml。

A lignan with diverse biological activities

牛磺酸脱氧胆酸盐(TUDCA)是包括肝细胞在内的多种细胞的细胞保护剂,也是癌症细胞凋亡的诱导剂。

An inhibitor of microtubule polymerization

BTR-1 induces cytotoxicity in a time- and concentration-dependent manner on leukemia cell line CEM. BTR-1 affects DNA replication by inducing a block at S phase and leads to activation of apoptosis to induce cell death.

cRIPGBM是RIPGBM的促凋亡衍生物，是通过与受体相互作用蛋白激酶2(RIPK2)结合，诱导GBM肿瘤干细胞凋亡的选择性诱导剂，对GBM-1细胞的EC50值为68nM。

JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.

Tauroursodeoxycholatedihydrate(TUDCAdihydrate;UR906dihydrate;Taurolitedihydrate)是一种内质网应激抑制剂。Tauroursodeoxycholate显著降低凋亡分子如caspase-3和caspase-12表达。Tauroursodeoxycholate也抑制ERK。

WYC-209是一种合成类视黄醇，能抑制恶性小鼠黑色素瘤肿瘤再生细胞(TRC)的增殖，IC50值为0.19μM。WYC-209主要细胞靶点是维甲酸受体(RARs)。

(20S)-Protopanaxatriol是一种来源于人参皂苷的代谢产物，具有多种生物活性和药理作用。

A chalcone with diverse biological activities

[8]-Shogaol，生姜中的一种刺激性酚类化合物，具有抗血小板活性 (IC50=5 μM) 和抑制 COX-2 (IC50=17.5 μM)。[8]-Shogaol 诱导人白血病细胞凋亡。

A triterpene with diverse biological activities

3-Dehydrotrametenolic acid，分离于茯苓菌核，是一种乳酸脱氢酶 (LDH) 抑制剂。3-Dehydrotrametenolic acid 促进体外脂肪细胞分化，在体内起胰岛素增敏剂的作用。3-Dehydrotrametenolic acid 诱导细胞凋亡，具有抗癌活性。

3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.

7,8-Dihydroxy-4-methylcoumarin (DHMC) is a precursor in the synthesis of derivatives of 4-methyl coumarin, which has excellent radical scavenging properties.

5-(N,N-Hexamethylene)-amiloride是一种强效的Na + /H + 交换体抑制剂，对肿瘤细胞具有毒性。

4',5,7-Trimethoxyflavone (5,7,4'-Trimethoxyflavone, TMF) is a flavonoid isolated from Kaempferia parviflora (KP) that induces apoptosis. 4',5,7-Trimethoxyflavone increases sub-G1 phase, DNA fragmentation, annexin-V/PI staining and Bax/Bcl-xL ratio, activates caspase-3 and degrades poly (ADP-ribose) polymerase (PARP) protein.

AAPK-25 是一种有效选择性的 Aurora/PLK 激酶双重抑制剂，具有抗肿瘤活性。AAPK-25 可引起有丝分裂延迟并阻滞前中期细胞，通过生物标志物组蛋白 H3Ser10 磷酸化反应，随后细胞凋亡激增。AAPK-25 靶向 Aurora-A, -B, -C 的 Kd 值为 23 nM-289 nM，靶向 PLK-1, -2, -3 的 Kd 值为 55-456 nM。

ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.

Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖，诱导自噬和凋亡。Actein 在体内几乎没有毒性。

AKT-IN-3 (compound E22) 是一种有效、口服的低 hERG 阻断 Akt 抑制剂，对 Akt1、Akt2 和 Akt3 作用的 IC50 值分别为 1.4 nM、1.2 nM 和 1.7 nM。AKT-IN-3 (compound E22) 对其他 AGC 家族激酶也有较好的抑制活性，如 PKA、PKC、ROCK1、RSK1、P70S6K、SGK。AKT-IN-3 (compound E22) 能诱导癌细胞凋亡，抑制癌细胞的转移。

A naphthoquinone with diverse biological activities