Sesamol is a lignan originally isolated from S. indicum that has diverse biological activities, including antioxidant, antibacterial, anticancer, and anti-obesity properties.1,2,3,4 Sesamol scavenges 2,2-diphenyl-1-picrylhydrazyl radicals with an IC50 value of 5.44 μg/ml and is active against B. cereus and S. aureus (MICs = 2 mg/ml for both).2 It also inhibits the growth of HepG2 human hepatocellular carcinoma cells in a concentration-dependent manner.3 Sesamol (100 mg/kg) reduces weight gain and hepatic steatosis in a mouse model of obesity induced by a high-fat diet (HFD).4
1.Majdalawieh, A.F., and Mansour, Z.R.Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of actionEur. J. Pharmacol.85575-89(2019) 2.Kumar, C.M., and Singh, S.A.Bioactive lignans from sesame (Sesamum indicum L.): Evaluation of their antioxidant and antibacterial effects for food applicationsJ. Food Sci. Technol.52(5)2934-2941(2015) 3.Liu, Z., Ren, B., Wang, Y., et al.Sesamol induces human hepatocellular carcinoma cells apoptosis by impairing mitochondrial function and suppressing autophagySci. Rep.75728(2017) 4.Lee, D.H., Chang, S.-H., Yang, D.-K., et al.Sesamol increases Ucp1 expression in white adipose tissues and stimulates energy expenditure in high-fat diet-fed obese miceNutrients12(5)1459(2020)