GlpBio

SOS1-IN-1

目录号: GC30511纯度: >99.50%
SOS1-IN-1 是一种选择性的变构 SOS1 抑制剂。 SOS1-IN-1 抑制变构位点活化，并部分抑制催化位点活化。 SOS1-IN-1 具有抗癌作用。
SOS1-IN-1
Cas No.: 4551-00-2
规格价格库存数量操作
250mg询价现货
1
500mg询价现货
1
电话: 400-920-5774Email: sales@glpbio.cn

文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

SOS1-IN-1 is a SOS1 inhibitor.

The growth inhibitory rate (IR)=(average OD value in the control group-average OD value in the treatment group)/average OD value in the control group×100% are compared. Treatments with SOS1-IN-1 at 40 μM and NSC-658497 at 30 μM result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of SOS1-IN-1 and NSC-658497 on cell growth inhibition. It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-ERK[1].

[1]. ARYL SULFONOHYDRAZIDES. WO 2016077793A1.

实验参考方法 Experimental Reference Method

Cell experiment:

MIA paca-2 cells (KRAS G12 C) are subjected to a 3-day proliferation assay following treatment with SOS1-IN-1 (NSC-70220: 40 μM), treatment with NSC-658497 (30 μM) and treatment with a combination of SOS1-IN-1 (40 μM) and NSC-658497 (30 μM). DMSO is used as the negative control[1].

References:

[1]. ARYL SULFONOHYDRAZIDES. WO 2016077793A1.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
4551-00-2
SMILES
O=[N+]([O-])C1=CC=CC=C1/C=C/C=C2C3=CC=CC=C3C4=CC=CC=C\24
分子式
C22H15NO2
分子量
325.36 g/mol
溶解性
DMSO: 12.5 mg/mL (38.42 mM)
保存条件
Store at -20°C,unstable in solution, ready to use.
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol