BTR-1 induces cytotoxicity in a time- and concentration-dependent manner on leukemia cell line CEM. BTR-1 affects DNA replication by inducing a block at S phase and leads to activation of apoptosis to induce cell death.
[1] Moorthy BT, et al. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6297-301.
















