GlpBio

KEAP1-Nrf2

The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.

KEAP1-Nrf2 相关产品(66)

  • GC70520 structure
    GC70520MIND4-17
    CAS: 345989-24-4
    纯度: >99.00%

    MIND4-17是一种强效的NRF2激活剂，共价修饰Keap1的C151残基。

  • GC70868 structure
    GC70868Nrf2 activator-3
    CAS: 2766570-23-2
    纯度: >98.00%

    Nrf2 activator-3是一种有效的Nrf2激活剂。

  • GC71031 structure
    GC71031Nrf2 activator-6
    CAS: 2728780-74-1
    纯度: 不显示

    Nrf2 activator-6四氢异喹啉化合物是Nrf2活化剂。

  • GC71072 structure
    GC71072NXPZ-2
    CAS: 2254492-08-3
    纯度: >98.00%

    NXPZ-2是一种口服活性Keap1-Nrf2蛋白-蛋白相互作用（PPI）抑制剂，Ki值为95 nM，EC50值为120和170 nM。

  • GC71232 structure
    GC71232I-152
    CAS: 311343-11-0
    纯度: >98.00%

    I-152是含有n -乙酰半胱氨酸(NAC)和半胱胺(MEA)的缀合物。

  • GC71544 structure
    GC71544Antroquinonol
    CAS: 1010081-09-0
    纯度: >98.00%

    Antroquinonol（（+）-Antroquinonol），一种从蘑菇Antrodia camphorata中提取的泛醌衍生物，具有保肝、抗炎和抗癌作用。

  • GC73243 structure
    GC73243Nrf2-IN-3
    CAS: 6325-13-9
    纯度: >99.00%

    Nrf2-IN-3（化合物R16）是一种Nrf2抑制剂。

  • GC74090 structure
    GC74090Dimethyl fumarate-d2
    CAS: 23057-98-9
    纯度: >99.00%

    Dimethyl fumarate-d2是氘标记的富马酸二甲酯。

  • GN10038 structure
    GN10038Ginsenoside Rh3
    CAS: 105558-26-7
    纯度: >99.50%

    Ginsenoside Rh3 是 Ginsenoside Rg5 的细菌代谢产物。

  • GN10318 structure
    GN10318Danshensu
    CAS: 22681-72-7
    纯度: >98.00%

    A salvianolic acid with diverse biological activities

  • GN10415 structure
    GN10415Astilbin
    CAS: 29838-67-3
    纯度: >97.00%

    A flavonoid with diverse biological activities

  • GN10470 structure
    GN10470Eriodictyol
    CAS: 552-58-9;4049-38-1
    纯度: >99.50%

    圣草酚是一种从中药中分离出来的黄酮类化合物，具有抗氧化和抗炎活性。

  • GN10491 structure
    GN10491Mangiferin
    CAS: 4773-96-0
    纯度: >99.50%

    A xanthone glucoside with diverse biological activities

  • GN10629 structure
    GN106295,7-dihydroxychromone
    CAS: 31721-94-5
    纯度: >99.00%

    5,7-dihydroxychromone是一种从花生壳中提取的黄酮类分解产物，能抑制曼陀罗、玉米、花生和小麦胚根的伸长。

  • GN10654 structure
    GN10654(+)-Corynoline
    CAS: 18797-79-0
    纯度: >98.00%

    An isoquinoline alkaloid with diverse biological activities

  • GN10741 structure
    GN10741Garcinone D
    CAS: 107390-08-9
    纯度: >98.00%

    A xanthone with diverse biological activities

  • GC16590 structure
    GC16590Dimethyl Fumarate
    CAS: 624-49-7
    纯度: >97.00%

    An antioxidant with immunological actions

  • GC13693 structure
    GC13693Omaveloxolone (RTA-408)
    CAS: 1474034-05-3
    纯度: >99.00% / >98.00%

    Omaveloxolone (RTA-408)是一种抗氧化炎症调节剂（AIM），可激活Nrf2并抑制一氧化氮（NO）的生成。