I-152 (1 mM; 1 h or 2 h) reduces the NRF2 mRNA level in RAW 264.7 cells[1].
I-152 (1 mM; 0-60 min) reduces the level of NRF2 and p53, increases the expression of ATF4 in RAW 264.7 cells[1].
I-152 (0.062, 0.125, 0.25 or 1 mM) increases the level of Gclc mRNA (6 h or 24 h), Chac1 mRNA (6 h or 24 h) and Chop mRNA (6 h) in RAW 264.7 cells[1].
I-152 (0.062, 0.125, 0.25 or 1 mM; 2 h) increases the level of GSH in RAW 264.7 cells[1].
I-152 (1 mM; 1, 2, 6 and 24 h) activates ATF4 mRNA expression in RAW 264.7 cells[1].
I-152 (1 mM; 24 h and 48 h) exhibits cytotoxic and growth inhibitory effects on RAW 264.7 cells[1].
References:
[1]. Crinelli R, et al. Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine. Antioxidants (Basel). 2021 Jan 26;10(2):175.