GlpBio

Bcl-2 Family

Bcl-2 Family(Bcl-2蛋白家族)

Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.

Bcl-2 Family 相关产品(120)

  • GC32998 structure
    GC32998Ginsenoside Rh4
    CAS: 174721-08-5
    纯度: >98.00%

    Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.

  • GC33035 structure
    GC33035Mcl1-IN-2
    CAS: 292057-76-2
    纯度: >98.00%

    Mcl1-IN-2 是骨髓细胞因子 1 (Mcl-1) 的抑制剂。 Mcl1-IN-2 是一种非竞争性的德里 metallo-β-lactamase (NDM-1) 抑制剂。

  • GC33052 structure
    GC33052VU0661013
    CAS: 2131184-57-9
    纯度: >98.50%

    VU661013 is a novel, potent, selective MCL1 inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. However, VU661013 does not significantly inhibit BCL-xL or BCL-2 with Ki > 40 μM or = 0.73 μM. VU661013 de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML.

  • GC33239 structure
    GC33239AZD-5991 S-enantiomer
    CAS: 2143061-82-7

    AZD-5991S-enantiomer是AZD-5991的低活性S型对映体。AZD-5991S-enantiomer是一种Mcl-1抑制剂，FRET实验检测的IC50为6.3μM，SPR实验检测的Kd为0.98μM。

  • GC33247 structure
    GC33247AZD-5991
    CAS: 2143061-81-6
    纯度: >98.50%

    An Mcl-1 inhibitor

  • GC33255 structure
    GC33255AZD4320
    CAS: 1357576-48-7
    纯度: >99.00%

    AZD4320是BH-3的新型类似物，有效的BCL2/BCLxL的双重抑制剂。AZD4320对于KPUM-MS3，KPUM-UH1，和STR-428细胞系的IC50分别为26nM，17nM，和170nM。

  • GC33283 structure
    GC33283AZD-5991 Racemate
    CAS: 2143010-83-5

    AZD5991 is a macrocyclic MCL-1 inhibitor with sub-nanomolar affinity for MCL-1 (Ki = 0.13 nM). The binding affinity of AZD5991 is about 25-fold lower for mouse Mcl-1 vs. human Mcl-1 but only four-fold lower for rat Mcl-1.

  • GC33295 structure
    GC33295MIK665 (S-64315)
    CAS: 1799631-75-6
    纯度: >98.50%

    An Mcl-1 inhibitor

  • GC33312 structure
    GC33312ML311
    CAS: 315698-17-0
    纯度: >98.00%

    An Mcl-1 inhibitor

  • GC33347 structure
    GC33347Mcl1-IN-3
    CAS: 1814891-79-6

    Mcl1-IN-3是Mcl1的抑制剂,来自专利专利WO2015153959A2，化合物实例57；IC50和Ki值分别为0.67和0.13μM。

  • GC33364 structure
    GC33364Mcl1-IN-4
    CAS: 1580484-04-3

    Mcl1-IN-4是Mcl1的抑制剂，IC50值为0.2μM。

  • GC33401 structure
    GC33401S55746 hydrochloride (BLC201 (hydrochloride))
    CAS: 1448525-91-4
    纯度: >98.50%

    S55746 hydrochloride (BLC201 (hydrochloride)) (BCL201 hydrochloride) 是一种有效的，具有口服活性的选择性 BCL-2 抑制剂，Ki 为 1.3 nM，Kd 为 3.9 nM。 S55746 hydrochloride (BLC201 (hydrochloride)) (BCL201 hydrochloride) 具有低毒的抗肿瘤活性。

  • GC33407 structure
    GC33407BM 957
    CAS: 1391107-54-2

    BM957是Bcl-2和Bcl-xL的有效抑制剂，其Ki值分别为1.2，<1nM，IC50值分别为5.4，6.0nM。

  • GC34096 structure
    GC34096(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))
    CAS: 866541-93-7
    纯度: >98.00%

    (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))是一种新型的、具有口服活性的Bcl-2家族蛋白抑制剂，可抑制Bcl-2（K i =260±30nM），Mcl-1（K i =170±10nM）和Bcl-xL（K i =480±40nM）。

  • GC34134 structure
    GC34134Glycocholic acid
    CAS: 475-31-0
    纯度: >98.00% / >97.00%

    Glycocholic acid是一种参与脂肪乳化的结晶胆汁酸，是胆酸与甘氨酸的结合物，它以钠盐的形式存在于哺乳动物的胆汁中。

  • GC34263 structure
    GC34263Bak BH3

    BakBH3是一种多肽，源于Bak蛋白的BH3结构域，在细胞中，能够抑制Bcl-xL的活性。

  • GC34389 structure
    GC34389PUMA BH3

    PUMABH3是一种p53正向凋亡调控因子(PUMA)BH3结构域多肽，作为Bak的直接激活剂，Kd值为26nM。

  • GC34980 structure
    GC34980(E)-Ferulic acid
    CAS: 537-98-4
    纯度: >99.00%

    Trans-ferulic acid is a potent activator of AMPKunder high glucose condition.

  • GC35001 structure
    GC35001(S)-Gossypol acetic acid
    CAS: 1189561-66-7
    纯度: >99.00%

    (S)-Gossypol acetic acid 是天然产物 Gossypol 的异构体。(S)-Gossypol 以高亲和力结合到 Bcl-xL 和 Bcl-2 蛋白的 BH3 结合沟。

  • GC35882 structure
    GC35882dMCL1-2
    CAS: 2351218-88-5

    dMCL1-2 是一种基于 PROTAC 技术的，高效、选择性的 MCL1 降解剂，结合 MCL1 的 KD 值为 30 nM。dMCL1-2 通过降解 MCL1 激活细胞凋亡。

  • GC36556 structure
    GC36556Mcl1-IN-1
    CAS: 713492-66-1
    纯度: >98.00%

    Mcl1-IN-1 是一种骨髓细胞因子 1 (Mcl-1) 抑制剂，IC50 为 2.4 ?M。

  • GC36557 structure
    GC36557Mcl1-IN-11
    CAS: 2042211-13-0

    Mcl1-IN-11 (Compound G) 是一种选择性的 Mcl-1 抑制剂，对 Bcl-2 的作用较弱，Ki 值分别为 0.06 和 4.2 μM。

  • GC36558 structure
    GC36558Mcl1-IN-12
    CAS: 2042211-12-9

    Mcl1-IN-12 (Compound F) 是一种选择性的 Mcl-1 抑制剂，对 Bcl-2 的作用较弱，Ki 值分别为 0.29 和 3.1 μM。

  • GC36559 structure
    GC36559Mcl1-IN-9
    CAS: 1810769-31-3

    Mcl1-IN-9 是一种有效的髓细胞白血病基因 1 (Mcl-1) 抑制剂，在重组的 BCR-ABL+ B-ALL 细胞中的 IC50 值为 446 nM，Ki 值为 0.03 nM。