Bcl-2 Family
Bcl-2 Family(Bcl-2蛋白家族)
Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.
Bcl-2 Family 相关产品(120)
- GC12405ABT-263 (Navitoclax)CAS: 923564-51-6纯度: >98.00%
ABT-263 (Navitoclax) 是 Bcl-xL、Bcl-2 和 Bcl-w 的抑制剂，Ki 分别≤0.5 nM、≤1 nM 和≤1 nM。
- GC13065Chelerythrine ChlorideCAS: 3895-92-9纯度: >98.50% / >98.00%
Chelerythrine Chloride是一种强效且可渗透细胞的蛋白激酶C（protein kinase C, PKC）抑制剂，IC 50 值为660nM。
- GC17008(+)-ApogossypolCAS: 66389-74-0
(+)-Apogossypol 是一种泛 BCL-2 拮抗剂。 (+)-Apogossypol 与 Mcl-1、Bcl-2 和 Bcl-xL 结合，EC50 分别为 2.6、2.8 和 3.69 μM。
- GC25673Obatoclax (GX15-070)CAS: 803712-67-6
Obatoclax (GX15-070) is an antagonist of Bcl-2 with an Ki of 0
- GC31806Bz 423 (BZ48)CAS: 216691-95-1纯度: >99.50%
Bz 423 (BZ48) 是一种促凋亡的 1,4-苯二氮卓类药物，在狼疮小鼠模型中具有治疗特性，显示出对自身反应性淋巴细胞的选择性，并激活 Bax 和 Bak。
- GC32947S55746 (BLC201)CAS: 1448584-12-0纯度: >99.50% / >98.00%
S55746 (S 055746,BCL201) is a novel, orally active BCL-2 specific inhibitor (Ki = 1.3 nM) with poor affinity for BCL-XL and no significant binding to MCL-1, BFL-1 (BCL2A1/A1). The selectivity of S55746 for BCL-2 versus BCL-XL ranges from ~70 to 400 folds.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC11921 | WEHI-539 | 1431866-33-9 | - | |
A selective Bcl-xL inhibitor | ||||
| GC12405 | ABT-263 (Navitoclax) | 923564-51-6 | >98.00% | |
ABT-263 (Navitoclax) 是 Bcl-xL、Bcl-2 和 Bcl-w 的抑制剂，Ki 分别≤0.5 nM、≤1 nM 和≤1 nM。 | ||||
| GC10567 | TCPOBOP | 76150-91-9 | >98.00% | |
TCPOBOP是一种构成性雄酮受体（CAR）激动剂（EC 50 =0.05μM），能够小鼠诱导肝细胞增殖和肝肿大，但不会造成肝损伤。 | ||||
| GC10661 | Destruxin B | 2503-26-6 | - | |
An insecticidal mycotoxin | ||||
| GC10721 | BDA-366 | 1909226-00-1 | - | |
A Bcl2-BH4 domain antagonist | ||||
| GC11140 | Radotinib(IY-5511) | 926037-48-1 | - | |
A selective Bcr-Abl tyrosine kinase inhibitor | ||||
| GC12621 | S63845 | 1799633-27-4 | >99.00% / >98.00% | |
S63845是一种有效的选择性骨髓细胞白血病1（MCL1）抑制剂，K d 值为0.19nM（人MCL1）。 | ||||
| GC12649 | TW-37 | 877877-35-5 | >99.00% | |
An inhibitor of the Bcl-2 family proteins | ||||
| GC12902 | Pyridoclax | 1651890-44-6 | >99.50% | |
Pyridoclax 是一种潜在的 Mcl-1 抑制剂。 | ||||
| GC13065 | Chelerythrine Chloride | 3895-92-9 | >98.50% / >98.00% | |
Chelerythrine Chloride是一种强效且可渗透细胞的蛋白激酶C（protein kinase C, PKC）抑制剂，IC 50 值为660nM。 | ||||
| GC13317 | WEHI-539 hydrochloride | 2070018-33-4 | >98.00% | |
A selective Bcl-xL inhibitor | ||||
| GC14069 | ABT-199 | 1257044-40-8 | >99.50% / >98.00% | |
Venetoclax (ABT-199, GDC-0199) 是 Bcl-2 的选择性抑制剂，在无细胞试验中 K i 为 0.01 nM。 | ||||
| GC15805 | UMI-77 | 518303-20-3 | >97.50% | |
A selective Mcl-1 inhibitor | ||||
| GC16278 | A-1210477 | 1668553-26-1 | >98.50% | |
A selective Mcl-1 inhibitor | ||||
| GC17008 | (+)-Apogossypol | 66389-74-0 | - | |
(+)-Apogossypol 是一种泛 BCL-2 拮抗剂。 (+)-Apogossypol 与 Mcl-1、Bcl-2 和 Bcl-xL 结合，EC50 分别为 2.6、2.8 和 3.69 μM。 | ||||
| GC17234 | ABT-737 | 852808-04-9 | >98.00% | |
ABT-737作为一种BH3模拟药物，是Bcl-2家族的抑制剂，可抑制Bcl 2、Bcl-xL和Bcl-w的活性，IC 50 值<1nM。 | ||||
| GC17512 | A-1155463 | 1235034-55-5 | >99.50% | |
A Bcl-xL inhibitor | ||||
| GC17513 | A-1331852 | 1430844-80-6 | >98.00% | |
A Bcl-xL inhibitor | ||||
| GC18136 | BH3I-1 | 300817-68-9 | >98.00% | |
An inhibitor of anti-apoptotic Bcl-2 proteins | ||||
| GC19452 | AMG-176 | 1883727-34-1 | >99.00% | |
AMG-176 (Tapotoclax) 是一种有效的、选择性的、具有口服活性的 MCL-1 抑制剂，Ki 为 0.13 nM。 | ||||
| GC25673 | Obatoclax (GX15-070) | 803712-67-6 | - | |
Obatoclax (GX15-070) is an antagonist of Bcl-2 with an Ki of 0 | ||||
| GC31806 | Bz 423 (BZ48) | 216691-95-1 | >99.50% | |
Bz 423 (BZ48) 是一种促凋亡的 1,4-苯二氮卓类药物，在狼疮小鼠模型中具有治疗特性，显示出对自身反应性淋巴细胞的选择性，并激活 Bax 和 Bak。 | ||||
| GC32947 | S55746 (BLC201) | 1448584-12-0 | >99.50% / >98.00% | |
S55746 (S 055746,BCL201) is a novel, orally active BCL-2 specific inhibitor (Ki = 1.3 nM) with poor affinity for BCL-XL and no significant binding to MCL-1, BFL-1 (BCL2A1/A1). The selectivity of S55746 for BCL-2 versus BCL-XL ranges from ~70 to 400 folds. | ||||
| GC32981 | A-385358 | 406228-55-5 | >98.50% | |
A-385358是Bcl-XL的一个选择性抑制剂，对于Bcl-XL和Bcl-2的Ki值分别为0.80和67nM。 | ||||