Marrubiin is a labdane diterpenoid lactone originally isolated from M. vulgare that has diverse biological activities.1,2,3 It inhibits potassium chloride-induced contractions of rat aortic rings (IC50 = 24 ?M).1 Marrubiin (100 mg/kg) inhibits ovalbumin-induced allergic ear edema in mice.2 It inhibits acetic acid-induced writhing and capsaicin-induced paw licking in mice with ID50 values of 2.2 and 28.8 ?mol/kg, respectively.3
1.El Bardai, S., Morel, N., Wibo, M., et al.The vasorelaxant activity of marrubenol and marrubiin from Marrubium vulgarePlanta Med.69(1)75-77(2003) 2.Stulzer, H.K., Tagliari, M.P., Zampirolo, J.A., et al.Antioedematogenic effect of marrubiin obtained from Marrubium vulgareJ. Ethnopharmacol.108(3)379-384(2006) 3.De Jesus, R.A., Cechinel-Filho, V., Oliveira, A.E., et al.Analysis of the antinociceptive properties of marrubiin isolated from Marrubium vulgarePhytomedicine7(2)111-115(2000)