Sinomenine Hydrochloride is an inhibitor of NF-κB activation [1]. Sinomenine Hydrochloride inhibits the production of inflammatory mediators, blocks sodium channels, and regulates immune cell activity, exerting anti-inflammatory, immunosuppressive, and analgesic effects [2-3]. Sinomenine Hydrochloride is primarily used to treat autoimmune and inflammatory diseases such as rheumatoid arthritis and osteoarthritis [4].
In HepG2 cells, Sinomenine Hydrochloride (0.5-2μM; 24-72h) significantly inhibits cell growth in a concentration- and time-dependent manner [5]. In MDA-MB-231 cells, Sinomenine Hydrochloride (0-5μM; 48h) inhibits the viability of human breast cancer cells [6]. In ACHN and 786-O cells, Sinomenine Hydrochloride (0-100μM; 24-72h) treatment suppresses the proliferation of ccRCC cells in a dose- and time-dependent manner [7].
In dextran sodium sulfate (DSS) induced colitis mice model, Sinomenine Hydrochloride (20mg/kg, 60mg/kg; ig; 7d) can downregulate the expression levels of Notch1, NICD1, Jagged1, and Hes1 proteins in the colon tissues of colitis mice [8]. In Pb-treated mice model, Sinomenine Hydrochloride (100mg/kg; po; 8 weeks) treatment reduced the levels of liver alanine aminotransferase, aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and MDA [9].
References:
[1]. Jiang S, Li S, Pang S, et al. A systematic review: Sinomenine[J]. Heliyon, 2024, 10(9).
[2]. Jiang W, Fan W, Gao T, et al. Analgesic mechanism of sinomenine against chronic pain[J]. Pain Research and Management, 2020, 2020(1): 1876862.
[3]. Hou W, Huang L, Huang H, et al. Bioactivities and mechanisms of action of sinomenine and its derivatives: a comprehensive review[J]. Molecules, 2024, 29(2): 540.
[4]. Li J, Cao J, Chen Q, et al. Investigating the therapeutic potential of sinomenine in rheumatoid arthritis: anti-inflammatory, antioxidant, and immunomodulatory mechanisms[J]. Naunyn-Schmiedeberg's Archives of Pharmacology, 2024, 397(6): 3945-3958.
[5]. Lu X L, Zeng J, Chen Y L, et al. Sinomenine hydrochloride inhibits human hepatocellular carcinoma cell growth in vitro and in vivo: Involvement of cell cycle arrest and apoptosis induction[J]. International journal of oncology, 2013, 42(1): 229-238.
[6]. Li X, Wang K, Ren Y, et al. MAPK signaling mediates sinomenine hydrochloride-induced human breast cancer cell death via both reactive oxygen species-dependent and-independent pathways: an in vitro and in vivo study[J]. Cell death & disease, 2014, 5(7): e1356-e1356.
[7]. Zhao B, Liu L, Mao J, et al. Sinomenine hydrochloride attenuates the proliferation, migration, invasiveness, angiogenesis and epithelial-mesenchymal transition of clear-cell renal cell carcinoma cells via targeting Smad in vitro[J]. Biomedicine & Pharmacotherapy, 2017, 96: 1036-1044.
[8]. Xu L, Liu W, Huang X, et al. Sinomenine hydrochloride improves DSS-induced colitis in mice through inhibition of the Notch signaling pathway[J]. BMC gastroenterology, 2024, 24(1): 451.
[9]. Li Y, Cai W, Ai Z, et al. Protective effects of sinomenine hydrochloride on lead-induced oxidative stress, inflammation, and apoptosis in mouse liver[J]. Environmental Science and Pollution Research, 2023, 30(3): 7510-7521.
Sinomenine Hydrochloride是NF-κB活化的抑制剂 [1]。Sinomenine Hydrochloride能够抑制炎症介质的产生，阻断钠通道，调节免疫细胞活性，发挥抗炎、免疫抑制和镇痛作用 [2-3]。Sinomenine Hydrochloride主要用于治疗自身免疫性疾病和炎症性疾病，例如类风湿性关节炎和骨关节炎 [4]。
在HepG2细胞中，Sinomenine Hydrochloride（0.5-2μM；24-72h）以浓度和时间依赖性方式显著抑制细胞生长 [5]。在MDA-MB-231细胞中，Sinomenine Hydrochloride（0-5μM；48h）可抑制人乳腺癌细胞的活力 [6]。在ACHN和786-O细胞中，Sinomenine Hydrochloride（0-100μM；24-72h）处理以剂量和时间依赖性方式抑制ccRCC细胞的增殖 [7]。
在葡聚糖硫酸钠（DSS）诱导的结肠炎小鼠模型中，Sinomenine Hydrochloride（20mg/kg，60mg/kg；ig；7d）可下调结肠炎小鼠结肠组织中Notch1、NICD1、Jagged1和Hes1蛋白的表达水平 [8]。在铅处理的小鼠模型中，Sinomenine Hydrochloride（100mg/kg；po；8周）治疗可降低肝脏丙氨酸氨基转移酶、天冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH）和丙二醛（MDA）的水平 [9]。