3,6-dichloro-benzo[b]thiophene-2-Carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) with a Ki value of 59 μM for binding of FITC-Mcl-1-BH2 peptide binding to Mcl-1.1 It has been used as a building block in the synthesis of inhibitors of Mcl-1, the toll-like receptor 3/double-stranded RNA (TLR3/dsRNA) complex, and D-amino acid oxidase (DAO).1,2,3
1.Friberg, A., Vigil, D., Zhao, B., et al.Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based designJ. Med. Chem.56(1)15-30(2013) 2.Cheng, K., Wang, X., and Yin, H.Small-molecule inhibitors of the TLR3/dsRNA complexJ. Am. Chem. Soc.133(11)3764-3767(2011) 3.Katane, M., Osaka, N., Matsuda, S., et al.Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitroJ. Med. Chem.56(5)1894-1907(2013)