Triamterene-d5 is intended for use as an internal standard for the quantification of triamterene by GC- or LC-MS. Triamterene is an inhibitor of the epithelial sodium channel (ENaC; IC50 = 4.5 ?M for the rat channel).1 In vivo, triamterene (0.5-32 mg/animal) enhances sodium secretion and decreases potassium secretion in adrenalectomized rats.2 Formulations containing triamterene have been used in the treatment of edema.
1.Kellenberger, S., Gautschi, I., and Schlid, L.Mutations in the epithelial Na+ channel ENaC outer pore disrupt amiloride block by increasing its dissociation rateMol. Pharmacol.64(4)848-856(2003) 2.Baba, W.I., Tudhope, G.R., and Wilson, G.M.Triamterene, a new diuretic drug. I. Studies in normal men and in adrenalectomized ratsBr. Med. J.2(5307)756-760(1962)