Indibulin is an inhibitor of microtubule assembly.1 It destabilizes microtubules and is selective for immature neuronal and nonneuronal microtubules over mature neuronal microtubules.2 Indibulin is cytotoxic to a variety of cancer cells, including human SKOV3 ovarian, U87 glioblastoma, and AsPC-1 pancreatic cancer cells (IC50s = 36, 77, and 285 nM, respectively).1 It also induces complete tumor regression in a rat Yoshida AH13 sarcoma model when administered at a dose of 10 mg/kg without inducing systemic or neurotoxicity.
1.Bacher, G., Nickel, B., Emig, P., et al.D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicityCancer Res.61(1)392-399(2001) 2.Wienecke, A., and Bacher, G.Indibulin, a novel microtubule inhibitor, discriminates between mature neuronal and nonneuronal tubulinCancer Res.69(1)171-177(2009)