YQ-128 is an inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome (IC50 = 0.3 ?M).1 It inhibits LPS- and ATP-induced IL-1β release from isolated mouse peritoneal macrophages (IC50 = 1.59 ?M). YQ-128 (10 mg/kg) inhibits LPS-induced IL-1β production in wild-type but not Nlrp3-/- mice.
1.Jiang, Y., He, L., Green, J., et al.Discovery of second-generation NLRP3 inflammasome inhibitors: Design, synthesis, and biological characterizationJ. Med. Chem.62(21)9718-9731(2019)