NOD-like Receptor (NLR)
NOD-like Receptor (NLR)(NOD样受体（NLR）)
Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are a specialized group of intracellular proteins that play a critical role in the regulation of the host innate immune response. NLRs act as scaffolding proteins that assemble signaling platforms that trigger nuclear factor-κB and mitogen-activated protein kinase signaling pathways and control the activation of inflammatory caspases. Importantly, mutations in several members of the NLR family have been linked to a variety of inflammatory diseases consistent with these molecules playing an important role in host-pathogen interactions and the inflammatory response. NLRs including Nod1 and Nod2 are thought to be kept in an inactive state by intra-molecular interactions.
The central role of the Nod-like receptor (NLR) protein family became increasingly appreciated in innate immune responses. NLRs are classified as part of the signal transduction ATPases with numerous domains (STAND) clade within the AAA+ ATPase family.
NOD-like Receptor (NLR) 相关产品(50)
- GC15811Nigericin sodium saltCAS: 28643-80-3纯度: >98.00% / >95.00%
尼杆菌素钠盐是一种来自湿地链霉菌的电中性K+/H+离子载体，它是一种亲脂性抗生素，可以选择性地导致钾从线粒体膜中流失。
- GC40928Trimethylamine N-oxideCAS: 1184-78-7纯度: >95.00%
A metabolite of choline, phosphatidylcholine, and L-carnitine
- GC61284Soyasaponin IICAS: 55319-36-3纯度: >99.50%
SoyasaponinII是具有抗病毒活性的皂苷。SoyasaponinII抑制HSV-1，HCMV，流感病毒和HIV-1的复制。SoyasaponinII对HSV-1复制显示出有效的抑制作用。SoyasaponinII作为YB-1磷酸化和NLRP3炎性小体引发的抑制剂，可保护小鼠免受LPS/GalN诱导的急性肝衰竭。
- GC62454MCC7840 sodiumCAS: 2380032-29-9纯度: >98.00%
MCC7840 (Emlenoflast), a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM.
- GC62507BMS-986299CAS: 2242952-69-6纯度: >99.50% / >98.00%
BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC10634 | MCC950 sodium | 256373-96-3 | >98.00% | |
MCC950 是一种有效的选择性小分子 NLRP3 抑制剂。 | ||||
| GC15811 | Nigericin sodium salt | 28643-80-3 | >98.00% / >95.00% | |
尼杆菌素钠盐是一种来自湿地链霉菌的电中性K+/H+离子载体，它是一种亲脂性抗生素，可以选择性地导致钾从线粒体膜中流失。 | ||||
| GC15933 | Troxerutin | 7085-55-4 | >98.00% | |
A flavonoid with diverse biological activities | ||||
| GC16641 | ML130 (Nodinitib-1) | 799264-47-4 | >99.50% | |
A selective NOD1 inhibitor | ||||
| GC19113 | CY-09 | 1073612-91-5 | >98.00% | |
CY-09 是 NLRP3 炎性体的特异性抑制剂，直接靶向 NLRP3，对五种主要细胞色素 P450 酶中的每一种酶的 IC50 值为 18.9、8.18、>50、>50 和 26.0 uM。 | ||||
| GC19201 | INF39 | 866028-26-4 | >99.00% | |
An NLRP3 inflammasome inhibitor | ||||
| GC31644 | MCC950 (CP-456773) | 210826-40-7 | >98.00% | |
An inhibitor of NLRP3 inflammasome activation | ||||
| GC31657 | NOD-IN-1 | 132819-92-2 | >99.50% | |
An inhibitor of NOD1 and NOD2 | ||||
| GC34555 | Dapansutrile | 54863-37-5 | >98.00% | |
Dapansutrile是一种口服小分子选择性NLRP3炎症小体抑制剂。 | ||||
| GC35385 | Arglabin | 84692-91-1 | >98.00% | |
A sesquiterpene lactone | ||||
| GC39311 | YQ128 | 2454246-18-3 | >99.50% | |
An NLRP3 inflammasome inhibitor | ||||
| GC39719 | Nigericin | 28380-24-7 | >98.00% / >97.00% | |
A potassium ionophore | ||||
| GC40928 | Trimethylamine N-oxide | 1184-78-7 | >95.00% | |
A metabolite of choline, phosphatidylcholine, and L-carnitine | ||||
| GC50342 | CP 424174 | 210825-31-3 | - | |
An inhibitor of stimulus-coupled IL-1β post-translational processing | ||||
| GC50556 | NBC 19 | 2068818-75-5 | - | |
Potent NLRP3 inflammasome inhibitor | ||||
| GC50569 | NLRP3-IN-2 | 16673-34-0 | >98.50% | |
An NLRP3 inflammasome inhibitor | ||||
| GC50611 | NBC 6 | 2068818-02-8 | >99.00% | |
NBC 6 是一种有效的、选择性的 NLRP3 炎性体抑制剂 (IC50= 574 nM)，其作用独立于 Ca2+。 | ||||
| GC60887 | GSK717 | 1595278-21-9 | >99.50% / >99.00% | |
GSK717是一种有效的、选择性的NOD2(核苷酸结合寡聚结构域2)抑制剂。GSK717抑制壁酰二肽(MDP)诱导的NOD2介导的信号转导，抑制MDP刺激的HEK293/hNOD2细胞分泌IL-8中的IC50为400nM。 | ||||
| GC60958 | JC-171 | 2112809-98-8 | >99.50% | |
JC-171是选择性的NLRP3炎症小体抑制剂，抑制LPS/ATP诱导的巨噬细胞释放IL-1β的IC50值为8.45μM。 | ||||
| GC61284 | Soyasaponin II | 55319-36-3 | >99.50% | |
SoyasaponinII是具有抗病毒活性的皂苷。SoyasaponinII抑制HSV-1，HCMV，流感病毒和HIV-1的复制。SoyasaponinII对HSV-1复制显示出有效的抑制作用。SoyasaponinII作为YB-1磷酸化和NLRP3炎性小体引发的抑制剂，可保护小鼠免受LPS/GalN诱导的急性肝衰竭。 | ||||
| GC62300 | JC124 | 1638611-48-9 | - | |
JC124 是一种特异性的 NLRP3 炎症小体抑制剂。JC124 具有抗炎和神经保护作用。 | ||||
| GC62317 | NX-13 | 2389235-01-0 | >98.00% | |
NX-13是一种一流的，具有口服活性的肠道限制剂，选择性靶向并激活 NLRX1 通路，诱导免疫代谢改变。NX-13 可降低炎症性肠病的炎症反应。NX-13 可用于克罗恩病和溃疡性结肠炎的研究。 | ||||
| GC62454 | MCC7840 sodium | 2380032-29-9 | >98.00% | |
MCC7840 (Emlenoflast), a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. | ||||
| GC62507 | BMS-986299 | 2242952-69-6 | >99.50% / >98.00% | |
BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells. | ||||