W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.[1],[2],[3]
References
[1]. Katayama, N., Nishikawa, M., Komada, F., et al. A role for calmodulin in the growth of human hematopoietic progenitor cells. Blood 75(7), 1446-1454 (1990).
[2]. Tebar, F., Villalonga, P., Sorkina, T., et al. Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathway. Molecular Biology of the Cell 13(6), 2057-2068 (2002).
[3]. Sengupta, P., Ruano, M.J., Tebar, F., et al. Membrane-permeable calmodulin inhibitors (e.g. W-7/W-13) bind to membranes, changing the electrostatic surface potential: Dual effect of W-13 on epidermal growth factor receptor activation. The Journal of Biological Chemisty 282(11), 8474-8486 (2007).