GlpBio

TR antagonist 1

目录号: GC31402纯度: >98.50%
TRantagonist1是高亲和力的甲状腺激素受体(thyroidhormonereceptor(TR))拮抗剂，对TRα和TRβ的IC50值分别为36和22nM。
TR antagonist 1
Cas No.: 500794-88-7
规格价格库存数量操作
5mg¥4,950.00现货
1
10mg¥7,650.00现货
1
50mg¥22,950.00现货
1
100mg¥35,550.00现货
1
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文献被引

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产品描述 Description

TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.

TR antagonist 1 displays high affinity for both thyroid hormone TRα and TRβ (IC50=36 and 22 nM, respectively). TR antagonist 1 acts as a full antagonist in the TRAFR cell assay and the IC50 32 nM for both TRAFα1 and TRAFβ1[1].

TR antagonist 1 treatment lowers heart rate and shows a possible trend toward an increase of low-density lipoprotein cholesterol (LDL-C) in the cholesterol fed rat model[1].

[1]. Koehler K, et al. Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor. J Med Chem. 2006 Nov 16;49(23):6635-7.

产品文档 Product Documents

Purity:>98.50%

化学性质Chemical Properties

CAS 号
500794-88-7
SMILES
O=C(O)CCC1=CC(Br)=C(OC2=CC(/C=C/C3=CC=NC=C3)=C(O)C(C(C)C)=C2)C(Br)=C1.[E]
分子式
C25H23Br2NO4
分子量
561.26 g/mol
溶解性
DMSO : ≥ 83.3 mg/mL (148.42 mM)
保存条件
4°C, protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol