Eniporide is a selective inhibitor of human Na+/H+ exchanger isoform 1 (NHE-1) (IC50 = 4.5 nM).1 Inhibition with eniporide prevents calcium overload-induced myocardial ischemia-reperfusion injury in vitro and in vivo.2,3,4,5
1.Kawamoto, T., Kimura, H., Kusumoto, K., et al.Potent and selective inhibition of the human Na+/H+ exchanger isoform NHE1 by a novel aminoguanidine derivative T-162559Eur. J. Pharmacol.420(1)1-8(2001) 2.Counillon, L., Scholz, W., Lang, H.J., et al.Pharmacological characterization of stably transfected Na+/H+ antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic propertiesMol. Pharmacol.44(5)1041-1045(1993) 3.Masereel, B., Pochet, L., and Laeckmann, D.An overview of inhibitors of Na+/H+ exchangerEur. J. Med. Chem.38(6)547-554(2003) 4.An, J., Varadarajan, S.G., Camara, A.C., Q., et al.Blocking Na+/H+ exchange reduces [Na+]i and [Ca2+]i load after ischemia and improves function in intact heartsAm. J. Physiol. Heart Circ. Physiol.281(6)H2398-H2409(2001) 5.Knight, D.R., Smith, A.H., Flynn, D.M., et al.A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivoJ. Pharmacol. Exp. Ther.297(1)254-259(2001)