Tafenoquine is an aminoquinoline antimalarial agent.1 It is active against multidrug-resistant clinical isolates of P. falciparum (IC50s = 64.6-110.4 ng/ml). Tafenoquine (25 or 50 mg/kg) inhibits sporozoite transmission to mosquitos fed on P. berghei-infected mice.2 It also suppresses parasitemia in a hamster model of B. microti infection when administered at doses ranging from 3.25 to 52 mg/kg.3
1.Ohrt, C., Willingmyre, G.D., Lee, P., et al.Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitroAntimicrob. Agents Chemother.46(8)2518-2524(2002) 2.Coleman, R.E.Sporontocidal activity of the antimalarial WR-238605 against Plasmodium berghei ANKA in Anopheles stephensiAm. J. Trop. Med. Hyg.42(3)196-205(1990) 3.Marley, S.E., Eberhard, M.L., Steurer, F.J., et al.Evaluation of selected antiprotozoal drugs in the Babesia microti-hamster modelAntimicrob. Agents Chemother.41(1)91-94(1997)