2,3-dinor Thromboxane B2-d9

2,3-dinor Thromboxane B₂-d₉ (2,3-dinor TXB₂-d₉) contains 9 deuterium atoms at the 15, 15, 16, 16, 17, 17, 18, 18, and 18 positions. It is intended for use as an internal standard for the quantification of 2,3-dinor TXB₂ by GC- or LC-mass spectrometry. TXB₂ is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB₂ and 2,3-dinor TXB₂.¹ 2,3-dinor TXB₂ is an abundant urinary metabolite of TXB₂ and can be used as a marker for in vivo TXA₂ synthesis.^1,2,3 In healthy male volunteers, the median excretion of 2,3-dinor TXB₂ is 10.3 ng/hour (138 pg/mg creatine).²

1.Ciabattoni, G., Pugliese, F., Davi, G., et al.Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in manBiochimica et Biophysica Acta99266-70(1989) 2.Lawson, J.A., Brash, A.R., Doran, J., et al.Measurement of urinary 2,3-dinor-thromboxane B2 and thromboxane B2 using bonded-phase phenylboronic acid columns and capillary gas chromatography-negative-ion chemical ionization mass spectrometryAnalytical Biochemistry150463-470(1985) 3.Lawson, J.A., Patrono, C., Ciabattoni, G., et al.Long-lived enzymatic metabolites of thromboxane B2 in the human circulationAnal. Biochem.155(1)198-205(1986)