Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug (NSAID) sulindac.
In vitro: Sulindac sulfone treatment also inhibited PGE2 production by HCA-7 cells with an IC50 of 360 mmol/L. Sulindac sulfone at 100 mmol/L reduced 6-ketoPGFα by 29.2%. Sulindac sulfone reduced the colony number of HCA-7 and HCT-116 with an EC50 of 50 mmol/l[1]. Sulindac sulfone significantly decreased the expression of total cellular β-catenin (50% of control), pro-caspase 3 (49%), cyclin D1 (51%), and PPARδ (65%) in SW480 cells. No significant alteration in pro-caspase 3 or β-catenin expression was found in HCA7, LS174, or Caco-2 cells treated with sulindac sulfone. A dose-dependent reduction in TCF-mediated transcriptional activity was also observed in SW480 cells [2].
In vivo: Sulindac sulfone is capable of reducing the incidence, multiplicity and tumor burden in the azoxymethane AOM rat model of colorectal cancer. Sulindac sulfone had no effect on the growth of HCA-7, HCT-116 xenografts and cancer cell xenografts [1].
Clinical Trial: In patients with familial adenomatous polyposis, treatment of sulindac sulfone for a period of six months led to regression of small polyps [3].
References:
[1] Williams C S, Goldman A P, Sheng H, et al. Sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growth[J]. Neoplasia, 1999, 1(2): 170-176.
[2] CHANG W E N C H I L, Everley L C, Pfeiffer G R, et al. Sulindac Sulfone Is Most Effective in Modulating β‐Catenin‐Mediated Transcription in Cells with Mutant APC[J]. Annals of the New York Academy of Sciences, 2005, 1059(1): 41-55.
[3] Stoner G D, Budd G T, Ganapathi R, et al. Sulindac sulfone induced regression of rectal polyps in patients with familial adenomatous polyposis[M]//Colon Cancer Prevention. Springer US, 1999: 45-53.