Guanidinosuccinic acid

目录号: GC31413纯度: >97.00%同义词: 胍基琥珀酸

A guanidino compound with epileptogenic activity

Cas No.: 6133-30-8

规格	价格	库存	数量
10mg	¥315.00	现货	1
50mg	¥720.00	现货	1
100mg	¥1,260.00	现货	1
10mM (in 1mL DMSO)	¥347.00	现货	1

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610, 366–372 (2022)
Cell
187(9):2288-2304 (2024)
Cell
183(7):1867-1883 (2020)
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388(6745) (2025)
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387(6739) (2025)
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387(6734) (2025)
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产品描述 Description

N-Amidino-L-aspartic acid is a guanidino compound found in mammalian sera and the CNS.¹ It induces whole-cell currents in rat hippocampal slices, an effect that can be reversed by the NMDA receptor antagonists D-AP5 and ketamine. Intrahippocampal administration of N-amidino-L-aspartic acid induces status epilepticus and neuronal cell death in rats.² Cerebrospinal fluid and serum levels of N-amidino-L-aspartic acid are increased in patients with renal failure.^1,2

1.D'Hooge, R., Raes, A., Lebrun, P., et al.N-methyl-D-aspartate receptor activation by guanidinosuccinate but not by methylguanidine: Behavioural and electrophysiological evidenceNeuropharmacology35(4)433-440(1996) 2.Pan, J.C., Pei, Y.Q., An, L., et al.Epileptiform activity and hippocampal damage produced by intrahippocampal injection of guanidinosuccinic acid in ratNeurosci. Lett.209(2)121-124(1996)

实验参考方法 Experimental Reference Method

Animal experiment:

Mice[2]Randomly bred Swiss mice (male and female, body weight 13-25 g for the first series of experiments) are housed under standard environmentally controlled conditions. For another series of experiments, young Swiss mice 7, 14 and 21 days old are used. Injections of Guanidinosuccinic acid suspensions are delivered in volumes of 0.1 mL per 10 g body weight, i.p. and in doses between 250 and 1000 mg/kg (5 mice per dose, in duplicate). After injection, the mice are put in individual cylindrical transparent cages and observed for 1 h (for 2 h in the case of the young mice). Both CD50 and LD50 are calculated by probit analysis or moving average interpolation[2].

References:

[1]. Milstien S, et al. Role of intestinal microflora in the metabolism of guanidinosuccinic acid. J Bacteriol. 1973 May;114(2):641-4.
[2]. D'Hooge R, et al. Behavioral toxicity of guanidinosuccinic acid in adult and young mice. Toxicol Lett. 1992 Dec;64-65 Spec No:773-7.

产品文档 Product Documents

Purity:>97.00%

化学性质Chemical Properties

CAS 号

6133-30-8

同义词

胍基琥珀酸

SMILES

O=C(O)C[C@@H](C(O)=O)NC(N)=N

分子式

C₅H₉N₃O₄

分子量

175.14 g/mol

溶解性

DMSO : 75 mg/mL (428.23 mM);Water : 6 mg/mL (34.26 mM)

保存条件

Store at -20°C

General tips

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。

Shipping Condition

评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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