GlpBio

Sp-8-bromo-Cyclic AMPS (sodium salt)

目录号: GC44920纯度: >98.00%同义词: 8Bromoadenosine 3',5'cyclic Monophosphothioate SPIsomer, Sp8bromocAMPS
A PKA activator
Sp-8-bromo-Cyclic AMPS (sodium salt)
Cas No.: 1573115-90-8
规格价格库存数量操作
1mg¥3,419.00现货
1
5mg¥11,550.00现货
1
500μg¥1,802.00现货
1
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文献被引

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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

Sp-8-bromo-cyclic AMPS (Sp-8-bromo-cAMPS) is a cell-permeable, cAMP analog that combines an exocyclic sulfur substitution in the axial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. This configuration pools the structural features of two established cyclic-AMP-dependent protein kinase (PKA) activators, 8-bromo-cAMP and Sp-cAMPS . Sp-8-bromo-cAMPS is a PKA agonist (EC50 = 1.5 µM) with improved lipophilicity and is not readily degraded by cyclic nucleotide phosphodiesterases.

产品文档 Product Documents

Purity:>98.00%Appearance:A solid

化学性质Chemical Properties

CAS 号
1573115-90-8
同义词
8Bromoadenosine 3',5'cyclic Monophosphothioate SPIsomer, Sp8bromocAMPS
SMILES
O[C@H]1[C@H](N2C(Br)=NC3=C2N=CN=C3N)O[C@H]4[C@H]1OP(OC4)([O-])=S.[Na+]
分子式
C10H10BrN5O5PS•Na
分子量
446.2 g/mol
溶解性
DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 0.5 mg/ml,PBS (pH 7.2): 10 mg/ml
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol