8-Bromoadenosine 5'-triphosphate (8-Br-ATP) is an analog of ATP and an agonist of the purinergic P2X receptor.1 It induces contraction of isolated guinea pig bladder strips with a potency that is 0.19-fold that of ATP. 8-Br-ATP has been used in the determiniation of the nucleotide substrate specificity of yeast poly(A) polymerase.2 It is cytotoxic to multiple myeloma cells (IC50 = 23.1 μM).3
1.Howson, W., Taylor, E.M., Parsons, M.E., et al.Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder)Eur. J. Med. Chem.23(5)433-439(1988) 2.Chen, L.S., and Sheppard, T.L.Chain termination and inhibition of Saccharomyces cerevisiae poly(A) polymerase by C-8-modified ATP analogsJ. Biol. Chem.279(39)40405-40411(2004) 3.Wang, L., and MacDonald, R.C.Cationic phospholiposomes: Efficient delivery vehicles of anticancer derivatives of ATP to multiple myeloma cellsJ. Liposome Res.21(4)306-314(2011)