2'-Acetylacteoside is a phenylethanoid glycoside that has been found in C. deserticola and has diverse biological activities.1,2,3,4,5 It selectively inhibits aldose reductase over maltase and sucrase (IC50s = 0.071, >300, and 277 ?M, respectively, for the rat enzymes).1 2'-Acetylacteoside scavenges superoxide radicals in a cell-free assay and inhibits hemolysis induced by AAPH in isolated rat red blood cells in a concentration-dependent manner.2 It decreases glutamate-induced cytotoxicity in primary rat cortical neurons when used at concentrations of 0.1, 1, and 10 ?M and protects primary mouse hepatocytes against D-galactosamine-induced cytotoxicity (IC50 = 4.8 ?g/ml).3,4 2'-Acetylacteoside (10-40 mg/kg) prevents decreases in bone strength in ovariectomized mice.5
1.Morikawa, T., Ninomiya, K., Imamura, M., et al.Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in miceJ. Nat. Med.68(3)561-566(2014) 2.He, Z.-D., Lau, K.-M., Xu, H.-X., et al.Antioxidant activity of phenylethanoid glycosides from Brandisia hanceiJ. Ethnopharmacol.71(3)483-486(2000) 3.Koo, K.A., Sung, S.H., Park, J.H., et al.In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotomaPlanta Med.71(8)778-780(2005) 4.Morikawa, T., Pan, Y., Ninomiya, K., et al.Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosaBioorg. Med. Chem.18(5)1882-1890(2010) 5.Li, Y., Li, N., Zhao, X., et al.Beneficial effect of 2'-acetylacteoside on ovariectomized mice via modulating the function of bone resorptionBiomed. Pharmacother.131110747(2020)