GlpBio

Enterovirus

Enterovirus(肠道病毒)

Human rhinoviruses (HRVs) and enteroviruses (HEVs) belong to the Picornaviridae family and are prominent causes of respiratory disease. They share identical genomic organization and high sequence homology. Their genome is divided into three sections: a 5’untranslated region (5’UTR), an open reading frame of the polyprotein that codes for all four capsid proteins (VP1-4) and the non-structural genes, and a 3’untranslated region.

Enteroviruses are members of the picornavirus family, a large and diverse group of small RNA viruses. According to the present classification, the enterovirus genus comprises the following species: poliovirus, human enterovirus A (HEV-A) (coxackie A viruses and enterovirus 71), HEV-B (coxsackie B viruses, echoviruses, coxsackie A9 virus, and enteroviruses 69 and 73), HEV-C (coxsackie A viruses), HEV-D (enteroviruses 68 and 70), and at least three animal enterovirus species (bovine, simian, and porcine enteroviruses). They all contain a genome of approximately 7,500 bases and positive [(+)]-strand polarity. After infection of the host cell, the genome is translated in a cap-independent manner into a single polyprotein, which is subsequently processed by virus-encoded proteases into the structural capsid proteins and the nonstructural proteins, which are mainly involved in the replication of the virus.

Enterovirus 相关产品(24)

  • GC17737 structure
    GC17737PD 169316
    CAS: 152121-53-4
    纯度: >98.00%

    A specific p38 MAPK inhibitor

  • GC18620 structure
    GC18620EIDD-1931
    CAS: 3258-02-4
    纯度: >99.50%

    A ribonucleoside analog with antiviral activity

  • GC19296 structure
    GC19296Pirodavir
    CAS: 124436-59-5
    纯度: >99.00%

    A broad-spectrum antipicornaviral agent

  • GC32067 structure
    GC32067Pleconaril (VP 63843)
    CAS: 153168-05-9
    纯度: >98.00%

    A capsid-binding antipicornaviral agent

  • GC32120 structure
    GC32120Pocapavir (SCH-48973)
    CAS: 146949-21-5
    纯度: >99.00%

    Pocapavir (SCH-48973) (SCH-48973) 是一种具有口服活性的衣壳抑制剂。

  • GC38050 structure
    GC38050Hederasaponin B
    CAS: 36284-77-2
    纯度: >98.00%

    A triterpene saponin with antiviral and antioxidant activities

  • GC39066 structure
    GC39066Prunin
    CAS: 529-55-5
    纯度: >98.00%

    A flavonoid glycoside with diverse biological activities

  • GC39097 structure
    GC39097Mosloflavone
    CAS: 740-33-0

    Mosloflavone 从 Scutellaria baicalensis Georgi 中分离出的类黄酮，具有抗 EV71 活性。Mosloflavone 在病毒感染的初始阶段抑制 VP2 病毒复制和蛋白质表达，并抑制病毒 VP2 衣壳蛋白合成。 Mosloflavone 是有前途的杀菌剂，可抑制铜绿假单胞菌的毒力和生物膜形成。

  • GC39353 structure
    GC39353Brilliant Black BN
    CAS: 2519-30-4
    纯度: >60.00%

    Brilliant Black BN是一种偶氮染料和食品着色剂。

  • GC41462 structure
    GC41462cis-Resveratrol
    CAS: 61434-67-1
    纯度: >98.00%

    A phenolic antioxidant present in red wine

  • GC45990 structure
    GC45990Norwogonin
    CAS: 4443-09-8
    纯度: >95.00%

    A polyhydroxy flavone with diverse biological activities

  • GC48241 structure
    GC48241Vapendavir
    CAS: 439085-51-5
    纯度: >95.00%

    A capsid-binding antiviral agent

  • GC50441 structure
    GC50441Rupintrivir
    CAS: 223537-30-2
    纯度: >98.00%

    Rupintrivir是一种强效、不可逆的human rhinovirus (HRV) 3C protease抑制剂，抑制所有HRV血清型复制的平均EC 50 值为0.023μM。

  • GC60099 structure
    GC60099Carbocisteine
    CAS: 638-23-3
    纯度: >98.00%

    Carbocisteine (S-carboxymethyl-l-cysteine) is a very important pharmaceutical product with mucolitic activity and is normally used for the treatment of bronchitis and colds.

  • GC61130 structure
    GC61130NHC-triphosphate
    CAS: 34973-27-8
    纯度: >99.00%

    NHC-triphosphate是NHC的活性胞内磷酸盐代谢物(intracellularmetabolite)，以三磷酸盐的形式存在。NHC-triphosphate是病毒聚合酶(viralpolymerase)的弱底物替代物，会被并入HCV复制子RNA中。

  • GC61359 structure
    GC61359TTP-8307
    CAS: 950225-08-8
    纯度: >99.50%

    TTP-8307是几种鼻和肠道病毒(rhino-/enteroviruses)复制的有效抑制剂。TTP-8307通过干扰病毒RNA的合成抑制coxsackievirusB3病毒(CVB3;EC50=1.2μM)和poliovirus病毒。TTP-8307通过氧化甾醇结合蛋白(OSBP)发挥抗病毒活性。

  • GC61956 structure
    GC61956NHC-diphosphate
    CAS: 39023-73-9
    纯度: >98.50%

    NHC-diphosphate 是 NHC 的活性胞内磷酸化代谢物 (intracellular metabolite )，以二磷酸盐的形式存在。NHC 是一种嘧啶核糖核苷，是一种有效的抗病毒剂 (anti-virus agent)。NHC 有效抑制委内瑞拉马脑炎病毒 (VEEV)、基孔肯亚病毒 (CHIKV) 和丙型肝炎病毒 (HCV) 的复制。

  • GC61961 structure
    GC61961NHC-triphosphate tetrasodium

    NHC-triphosphate tetrasodium是 NHC的活性胞内磷酸盐代谢物 (intracellular metabolite )，以三磷酸盐的形式存在。NHC-triphosphate tetrasodium是病毒聚合酶 (viral polymerase) 的弱底物替代物，会被并入 HCV 复制子 RNA 中。

  • GC63291 structure
    GC63291WIN 54954
    CAS: 107355-45-3

    WIN 54954 是一种口服有效的广谱抗小核糖核酸病毒剂。WIN 54954 对人鼻病毒、埃可病毒 9 和肠道病毒感染有效。

  • GC64636 structure
    GC64636DMA-135 hydrochloride
    CAS: 2237925-62-9
    纯度: >99.00%

    DMA-135 hydrochloride 抑制肠道病毒 71 型 (EV71) IRES依赖的翻译和复制。DMA-135 hydrochloride 以中等高亲和力(KD=?520? nM) 结合 EV71 的 SLII 结构域。DMA-135 hydrochloride 在基于细胞的研究中没有显著毒性。

  • GC68675 structure
    GC68675Antiviral agent 24
    CAS: 23661-03-2
    纯度: >99.00%

    Antiviral agent 24 是一种有效的抗病毒剂，对 EV71、CVA21、EV68 的 EC50 值分别为 0.101、19.9、91.2 µM。Antiviral agent 24 以剂量依赖性方式抑制 METTL3/METTL14 活性。

  • GC70206 structure
    GC70206(Rac)-Golgicide A
    CAS: 1005036-73-6
    纯度: 不显示

    (Rac)-Golgicide A Rac-GCA是Golgicide a的外消旋物。

  • GC70504 structure
    GC70504AN-12-H5
    CAS: 1193340-31-6
    纯度: >98.00%

    AN-12-H5一种抗肠道病毒化合物，靶向PV和肠道病毒71型（EV71）的复制过程。

  • GC70549 structure
    GC70549DC07090 dihydrochloride
    CAS: 1158264-37-9
    纯度: >99.00%

    DC07090 dihydrochloride是一种低毒、强效、可逆和竞争性的非肽基人肠道病毒71 3C蛋白酶抑制剂，IC50和Ki值分别为21.72μM和23.29μM。