Antiviral agent 24 is a potent antiviral agent with EC50 values of 0.101, 19.9, 91.2 µM for EV71, CVA21, EV68, respectively. Antiviral agent 24 inhibits METTL3/METTL14 activity in a dose-dependent manner[1].
Antiviral agent 24 (compound 25) (0-1000 µM) 抑制 METTL3/METTL14 复合物活性,EC50 值为 129 µM[1]。
[1]. Salerno M, et al. Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71. Eur J Med Chem. 2022 Nov 24;246:114942.
















