GlpBio

PDGFR

PDGFR(血小板衍生生长因子受体)

PDGFR (platelet-derived growth factor receptor) is a group of cell surface tyrosine kinase receptors for members of the PDGF (platelet-derived growth factor) family.

PDGFR 相关产品(107)

  • GC12216 structure
    GC12216Axitinib (AG 013736)
    CAS: 319460-85-0
    纯度: >99.50% / >98.00%

    Axitinib (AG 013736)是一种具有口服活性的特异性血管内皮生长因子受体（VEGFR）抑制剂，主要靶向VEGFR-1、VEGFR-2和VEGFR-3，IC 50 值分别为 0.1nM、0.2nM和0.1-0.3nM。

  • GC12686 structure
    GC12686SU 16f
    CAS: 251356-45-3
    纯度: >98.00% / >99.50%

    SU 16f是一种有效的酪氨酸激酶抑制剂，可抑制VEGF-R2、FGF-R1和PDGFRβ，IC 50 值分别为0.14、2.29和0.01μM。

  • GC12730 structure
    GC12730Pazopanib Hydrochloride
    CAS: 635702-64-6
    纯度: >99.50%

    A multi-kinase inhibitor

  • GC12980 structure
    GC12980CP-673451
    CAS: 343787-29-1
    纯度: >99.50%

    A selective PDGFRα/β kinase inhibitor

  • GC13264 structure
    GC13264Ki20227
    CAS: 623142-96-1
    纯度: >98.00%

    A c-Fms kinase inhibitor

  • GC13547 structure
    GC13547Dovitinib (TKI-258, CHIR-258)
    CAS: 405169-16-6
    纯度: >98.00%

    Dovitinib (TKI-258, CHIR-258)是一种高效，具有口服活性和安全药代动力学特性的小分子多激酶抑制剂，作用于FLT3、KIT和FGFR等靶点，IC 50 值分别为1、2和8-9nM。

  • GC14315 structure
    GC14315SU14813 maleate
    CAS: 849643-15-8
    纯度: >99.50%

    A dual VEGFR and PDGFR family kinase inhibitor

  • GC14396 structure
    GC14396Ponatinib (AP24534)
    CAS: 943319-70-8
    纯度: >99.00%

    Ponatinib (AP24534)是一种多靶点酪氨酸激酶抑制剂，可抑制Abl（IC 50 =0.37nM），PDGFRα（IC 50 =1.1nM），VEGFR2（IC 50 =1.5nM），FGFR1（IC 50 =2.2nM）和Src（IC 50 =5.4nM）的活性。

  • GC14534 structure
    GC14534Regorafenib monohydrate
    CAS: 1019206-88-2
    纯度: >99.50%

    A multi-kinase inhibitor

  • GC14544 structure
    GC14544JNJ-10198409
    CAS: 627518-40-5
    纯度: >97.00%

    A potent PDGF tyrosine kinase inhibitor

  • GC14606 structure
    GC14606Regorafenib hydrochloride
    CAS: 835621-07-3
    纯度: >99.50%

    A multi-kinase inhibitor

  • GC14660 structure
    GC14660SU 5402
    CAS: 215543-92-3
    纯度: >98.00%

    SU 5402是一种多靶点受体酪氨酸激酶抑制剂，对血管内皮生长因子受体2（VEGF-R2）和成纤维细胞生长因子受体1（FGF-R1）酪氨酸激酶活性的IC 50 分别为20nM和30nM。

  • GC14676 structure
    GC14676Pacritinib (SB1518)
    CAS: 937272-79-2

    An equipotent inhibitor of FLT3 and JAK2

  • GC14733 structure
    GC14733SU14813
    CAS: 627908-92-3
    纯度: >98.50%

    A dual VEGFR and PDGFR family kinase inhibitor

  • GC14906 structure
    GC14906Crenolanib (CP-868596)
    CAS: 670220-88-9
    纯度: >99.50%

    An inhibitor of PDGFRα/β and FLT3

  • GC15254 structure
    GC15254Tandutinib (MLN518)
    CAS: 387867-13-2
    纯度: >99.00%

    An antagonist of PDGFRβ, FLT3, and c-Kit

  • GC15454 structure
    GC15454Lenvatinib (E7080)
    CAS: 417716-92-8
    纯度: >99.50%

    E7080，称为乐伐替尼，是一种口服多靶点酪氨酸激酶抑制剂，包括 VEGF、FGF 和 SCF 受体，已被证明可以提高放射性碘难治性甲状腺癌患者的生存率。

  • GC15739 structure
    GC15739CHIR-124
    CAS: 405168-58-3
    纯度: >98.00%

    A selective Chk1 inhibitor

  • GC16235 structure
    GC16235AG-1295
    CAS: 71897-07-9
    纯度: >99.50%

    A selective inhibitor of PDGF receptor kinase

  • GC16421 structure
    GC16421Cediranib (AZD217)
    CAS: 288383-20-0
    纯度: >99.50%

    An inhibitor of VEGF receptor tyrosine kinases

  • GC16499 structure
    GC16499Sorafenib Tosylate
    CAS: 475207-59-1
    纯度: >99.50%

    A multi-kinase inhibitor

  • GC16519 structure
    GC16519ENMD-2076
    CAS: 934353-76-1
    纯度: >98.00%

    A multi-kinase inhibitor

  • GC16732 structure
    GC16732TSU-68 (SU6668,Orantinib)
    CAS: 252916-29-3
    纯度: >98.50%

    An inhibitor of select receptor tyrosine kinases

  • GC17024 structure
    GC17024DMPQ dihydrochloride
    CAS: 1123491-15-5

    An potent inhibitor of PDGFRβ